Evolution of nanomedicines for the treatment of autoimmune disease: From vehicles for drug delivery to inducers of bystander immunoregulation

TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study

(2021) Ciarán P. Kelly et al.   GASTROENTEROLOGY

Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP

(2021) Channakeshava Sokke Umeshappa et al.   Cell Reports

Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity

(2020) Channakeshava Sokke Umeshappa et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevention and treatment of autoimmune diseases with plant virus nanoparticles

(2020) Roberta Zampieri et al.   Science Advances

TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model

(2020) Ethan J. Bassin et al.   PLoS One

Induction of Antigen-Specific Tolerance in T Cell Mediated Diseases

(2020) Laura Passerini et al.   Frontiers in Immunology

Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses

(2020) Maigan A. Brusko et al.   Frontiers in Immunology

Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease

(2020) Eiji Saito et al.   Science Advances

Tolerogenic nanoparticles suppress central nervous system inflammation

(2020) Jessica E. Kenison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual-sized microparticle system generates suppressive dendritic cells, and prevents and reverses type 1 diabetes in the non-obese diabetic mouse

(2019) Jamal S Lewis et al.   ACS Biomaterials-Science & Engineering

Antigen-specific therapeutic approaches for autoimmunity

(2019) Pau Serra et al.   NATURE BIOTECHNOLOGY

Review of polysaccharide particle-based functional drug delivery

(2019) Thomas G. Barclay et al.   CARBOHYDRATE POLYMERS

Nanoparticles Containing an Insulin–ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells

(2019) Braxton L. Jamison et al.   JOURNAL OF IMMUNOLOGY

Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

(2019) Channakeshava Sokke Umeshappa et al.   Nature Communications

Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

(2019) Manon A.A. Jansen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease

(2019) Eiji Saito et al.   BIOMATERIALS

Oral delivery of single-chain insulin (SCI-59) analog by bacterium-like particles (BLPs) induces oral tolerance and prevents autoimmune diabetes in NOD mice

(2019) Ruifeng Mao et al.   IMMUNOLOGY LETTERS

Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation

(2019) James D. Fisher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

(2018) Niranjan G. Kotla et al.   ADVANCED DRUG DELIVERY REVIEWS

Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells

(2018) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate

(2018) Abdulaziz M. Aldayel et al.   JOURNAL OF CONTROLLED RELEASE

Approaches to Improve Therapeutic Efficacy of Biodegradable PLA/PLGA Microspheres: A Review

(2018) Soo-Ling Bee et al.   Polymer Reviews

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

(2018) Riley P. Allen et al.   ACS Biomaterials-Science & Engineering

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

(2018) Riley P. Allen et al.   ACS Biomaterials Science & Engineering

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

pH-sensitive polymeric micelles for targeted delivery to inflamed joints

(2017) Chunhong Li et al.   JOURNAL OF CONTROLLED RELEASE

Acid-Sensitive Sheddable PEGylated, Mannose-Modified Nanoparticles Increase the Delivery of Betamethasone to Chronic Inflammation Sites in a Mouse Model

(2017) Hannah L. O’Mary et al.   MOLECULAR PHARMACEUTICS

Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance

(2017) Robert Kuo et al.   MOLECULAR THERAPY

Evolution and clinical translation of drug delivery nanomaterials

(2017) Shabir Hassan et al.   Nano Today

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

(2017) Santiswarup Singha et al.   Nature Nanotechnology

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

(2017) Soracha Thamphiwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases

(2017) Davide Prosperi et al.   SEMINARS IN IMMUNOLOGY

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model

(2017) Michelle L. Ratay et al.   Scientific Reports

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

A liposomal steroid nano-drug for treating systemic lupus erythematosus

(2016) E Moallem et al.   LUPUS

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

(2016) Takashi K. Kishimoto et al.   Nature Nanotechnology

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

(2016) A. Borroto et al.   Science Translational Medicine

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

New Developments in Liposomal Drug Delivery

(2015) Bhushan S. Pattni et al.   CHEMICAL REVIEWS

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice

(2015) Jamal S. Lewis et al.   CLINICAL IMMUNOLOGY

Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation

(2015) Carl Engman et al.   CLINICAL IMMUNOLOGY

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

(2015) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice

(2015) Kotaro Otomo et al.   JOURNAL OF IMMUNOLOGY

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

(2014) Jung Min Shin et al.   CHEMICAL COMMUNICATIONS

Hyaluronan nanoparticles bearing γ-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritis

(2014) Roun Heo et al.   JOURNAL OF CONTROLLED RELEASE

Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis

(2014) Hamed Laroui et al.   JOURNAL OF CONTROLLED RELEASE

Synthetic Peptide Dendrimers Block the Development and Expression of Experimental Allergic Encephalomyelitis

(2014) K. W. Wegmann et al.   JOURNAL OF IMMUNOLOGY

Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis

(2014) Maria Lapteva et al.   MOLECULAR PHARMACEUTICS

Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery

(2014) Vincent Pavot et al.   Nanomedicine

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clearance of pathological antibodies using biomimetic nanoparticles

(2014) Jonathan A. Copp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Subcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitis

(2014) Giuseppe Cappellano et al.   VACCINE

Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice

(2013) Michael Look et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis

(2013) So Jin Lee et al.   MOLECULAR THERAPY

A biomimetic nanosponge that absorbs pore-forming toxins

(2013) Che-Ming J. Hu et al.   Nature Nanotechnology

Back to the future: oral targeted therapy for RA and other autoimmune diseases

(2013) John J. O'Shea et al.   Nature Reviews Rheumatology

Oral Gene Application Using Chitosan-DNA Nanoparticles Induces Transferable Tolerance

(2012) Katja Goldmann et al.   Clinical and Vaccine Immunology

MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model

(2012) Bernard C.M. te Boekhorst et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells

(2012) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

(2012) A. Yeste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis

(2011) Nils Schweingruber et al.   JOURNAL OF IMMUNOLOGY

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

Polyketal microparticles for therapeutic delivery to the lung

(2009) Vincent F. Fiore et al.   BIOMATERIALS

Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3− regulatory T cells suppressing autoimmune hepatitis

(2009) Nils Kruse et al.   HEPATOLOGY

Treatment of Experimental Arthritis with Stealth-Type Polymeric Nanoparticles Encapsulating Betamethasone Phosphate

(2009) T. Ishihara et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PEG Minocycline-Liposomes Ameliorate CNS Autoimmune Disease

(2009) Wei Hu et al.   PLoS One

Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment

(2009) Una Rauchhaus et al.   ARTHRITIS RESEARCH & THERAPY

Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice

(2008) Rémi J. Creusot et al.   CLINICAL IMMUNOLOGY

A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes

(2008) B. Phillips et al.   DIABETES

Poly (lactide-co-glycolide)-Polymethacrylate Nanoparticles for Intramuscular Delivery of Plasmid Encoding Interleukin-10 to Prevent Autoimmune Diabetes in Mice

(2008) Ashwin Basarkar et al.   PHARMACEUTICAL RESEARCH