标题
Synthetic modified messenger RNA for therapeutic applications
作者
关键词
Synthetic modified mRNA, Therapeutic mRNA, RNA base modifications, mRNA vaccines, mRNA delivery
出版物
Acta Biomaterialia
Volume 131, Issue -, Pages 1-15
出版商
Elsevier BV
发表日期
2021-06-13
DOI
10.1016/j.actbio.2021.06.020
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
- (2021) Weinan Qiu et al. Nature Communications
- The combined disulfide cross-linking and tyrosine-modification of very low molecular weight linear PEI synergistically enhances transfection efficacies and improves biocompatibility
- (2021) Michael Karimov et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- The challenge and prospect of mRNA therapeutics landscape
- (2020) Yuhua Weng et al. BIOTECHNOLOGY ADVANCES
- N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells
- (2020) Callum J C Parr et al. NUCLEIC ACIDS RESEARCH
- Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives
- (2020) Itziar Gómez-Aguado et al. Nanomaterials
- N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I
- (2020) Mijia Lu et al. Nature Microbiology
- Opportunities and Challenges in the Delivery of mRNA-Based Vaccines
- (2020) Abishek Wadhwa et al. Pharmaceutics
- Multiple links between 5-methylcytosine content of mRNA and translation
- (2020) Ulrike Schumann et al. BMC BIOLOGY
- Toll-like Receptors and the Control of Immunity
- (2020) Katherine A. Fitzgerald et al. CELL
- A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice
- (2020) Alec W. Freyn et al. MOLECULAR THERAPY
- Author Correction: A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- The race for coronavirus vaccines: a graphical guide
- (2020) Ewen Callaway NATURE
- The RNA modification N6-methyladenosine as a novel regulator of the immune system
- (2020) Ziv Shulman et al. NATURE IMMUNOLOGY
- Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
- (2020) Lei Miao et al. Nature Communications
- Naturally occurring modified ribonucleosides
- (2020) Phillip J. McCown et al. Wiley Interdisciplinary Reviews-RNA
- Multi-antigen DNA vaccine delivered by polyethylenimine and Salmonella enterica in neuroblastoma mouse model
- (2020) Maria V. Stegantseva et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A Thermostable mRNA Vaccine against COVID-19
- (2020) Na-Na Zhang et al. CELL
- Recent advances in mRNA vaccine technology
- (2020) Norbert Pardi et al. CURRENT OPINION IN IMMUNOLOGY
- A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice
- (2020) Dorottya Laczkó et al. IMMUNITY
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
- (2020) Kizzmekia S. Corbett et al. NATURE
- Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults
- (2020) Mark J. Mulligan et al. NATURE
- mRNA vaccines: intellectual property landscape
- (2020) Cecilia Martin et al. NATURE REVIEWS DRUG DISCOVERY
- Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
- (2020) Kizzmekia S. Corbett et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pseudouridine as a novel biomarker in prostate cancer
- (2020) Jennifer A. Stockert et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection
- (2020) Kevin P. Egan et al. PLoS Pathogens
- Modified mRNA-LNP vaccines confer protection against experimental DENV-2 infection in mice
- (2020) Mengling Zhang et al. Molecular Therapy-Methods & Clinical Development
- mRNA Vaccines: Possible Tools to Combat SARS-CoV-2
- (2020) Changhua Yi et al. VIROLOGICA SINICA
- Regulation and Function of RNA Pseudouridylation in Human Cells
- (2020) Erin K. Borchardt et al. Annual Review of Genetics
- Recent developments of RNA-based vaccines in cancer immunotherapy
- (2020) Elnaz Faghfuri et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Nanomedicine-Based Approaches for mRNA Delivery
- (2020) Satoshi Uchida et al. MOLECULAR PHARMACEUTICS
- Paving the Road for RNA Therapeutics
- (2020) Niels Dammes et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer
- (2020) Chen Xue et al. Biomarker Research
- Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing
- (2020) Qiubing Chen et al. ADVANCED DRUG DELIVERY REVIEWS
- Readers of the m6A epitranscriptomic code
- (2019) Soizik Berlivet et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- RNA Modifications Modulate Activation of Innate Toll-Like Receptors
- (2019) Isabel Freund et al. Genes
- Eukaryotic Translation Elongation is Modulated by Single Natural Nucleotide Derivatives in the Coding Sequences of mRNAs
- (2019) Thomas Philipp Hoernes et al. Genes
- Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering
- (2019) Zohreh Sadat Badieyan et al. Stem Cells Translational Medicine
- Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells
- (2019) Lea Anhäuser et al. NUCLEIC ACIDS RESEARCH
- mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
- (2019) Giulietta Maruggi et al. MOLECULAR THERAPY
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA
- (2019) Li-Sheng Zhang et al. MOLECULAR CELL
- MRNA Delivery For Therapeutic Anti-Her2 Antibody Expression In Vivo
- (2019) Yulia Rybakova et al. MOLECULAR THERAPY
- Genome-wide identification of mRNA 5-methylcytosine in mammals
- (2019) Tao Huang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials
- (2019) Robert A. Feldman et al. VACCINE
- Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
- (2019) Anna K. Blakney et al. GENE THERAPY
- Three decades of messenger RNA vaccine development
- (2019) Rein Verbeke et al. Nano Today
- Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes
- (2019) Sita Awasthi et al. Science Immunology
- N6-Methyladenosine Modification Controls Circular RNA Immunity
- (2019) Y. Grace Chen et al. MOLECULAR CELL
- Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA
- (2019) Oscar Quintana-Bustamante et al. PLoS One
- mRNA structure regulates protein expression through changes in functional half-life
- (2019) David M. Mauger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GC content shapes mRNA storage and decay in human cells
- (2019) Maïté Courel et al. eLife
- Fluorescence Correlation Spectroscopy to find the critical balance between extracellular association and intracellular dissociation of mRNA complexes
- (2018) Heyang Zhang et al. Acta Biomaterialia
- Codon Optimization in the Production of Recombinant Biotherapeutics: Potential Risks and Considerations
- (2018) Vincent P. Mauro BIODRUGS
- Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine
- (2018) Hyokyoung Kwon et al. BIOMATERIALS
- 3′-Modification stabilizes mRNA and increases translation in cells
- (2018) Christian Gampe et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
- (2018) Ying Yang et al. CELL RESEARCH
- Delivery of a Modified mRNA Encoding IL-22 Binding Protein (IL-22BP) for Colon Cancer Gene Therapy
- (2018) Rui Zhang et al. Journal of Biomedical Nanotechnology
- Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells
- (2018) A. Le Moignic et al. JOURNAL OF CONTROLLED RELEASE
- Long Terminal Repeat CRISPR-CAR-Coupled “Universal” T Cells Mediate Potent Anti-leukemic Effects
- (2018) Christos Georgiadis et al. MOLECULAR THERAPY
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- 2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation
- (2018) Junhong Choi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles
- (2018) Marianna Yanez Arteta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins
- (2018) Deepak P. Patil et al. TRENDS IN CELL BIOLOGY
- Nanoscale platforms for messenger RNA delivery
- (2018) Bin Li et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- 2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation
- (2018) Junhong Choi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Delivery of modified mRNA encoding vesicular stomatitis virus matrix protein for colon cancer gene therapy
- (2018) Ke Men et al. RSC Advances
- Poly(β-amino ester)-co -poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo
- (2018) Umberto Capasso Palmiero et al. Advanced Healthcare Materials
- Translation initiation by cap-dependent ribosome recruitment: Recent insights and open questions
- (2018) Nikolay E. Shirokikh et al. Wiley Interdisciplinary Reviews-RNA
- Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification
- (2018) Sriram Vaidyanathan et al. Molecular Therapy-Nucleic Acids
- Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety
- (2018) Kevin Van der Jeught et al. ACS Nano
- Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs
- (2018) Owen S. Fenton et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
- (2018) James C. Kaczmarek et al. NANO LETTERS
- MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct
- (2018) Ruchi Jain et al. Nucleic Acid Therapeutics
- RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions
- (2018) Lilia Ayadi et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Acetylation of Cytidine in mRNA Promotes Translation Efficiency
- (2018) Daniel Arango et al. CELL
- mRNA-Based Genetic Reprogramming
- (2018) Luigi Warren et al. MOLECULAR THERAPY
- mRNA therapeutics deliver a hopeful message
- (2018) Zifu Zhong et al. Nano Today
- 5′ and 3′ modifications controlling RNA degradation: from safeguards to executioners
- (2018) Dominique Gagliardi et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Highly Efficient In Vivo Targeting of the Pulmonary Endothelium Using Novel Modifications of Polyethylenimine: An Importance of Charge
- (2018) Andrew W. Dunn et al. Advanced Healthcare Materials
- Cytotoxicity of polycations: Relationship of molecular weight and the hydrolytic theory of the mechanism of toxicity
- (2017) Bryn D. Monnery et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation
- (2017) Qiu Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial
- (2017) Martin Alberer et al. LANCET
- 5-Methylcytosine RNA Methylation in Arabidopsis Thaliana
- (2017) Xuean Cui et al. Molecular Plant
- A Targeted and Stable Polymeric Nanoformulation Enhances Systemic Delivery of mRNA to Tumors
- (2017) Qixian Chen et al. MOLECULAR THERAPY
- Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
- (2017) Norbert Pardi et al. NATURE
- Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
- (2017) Hao Yin et al. NATURE BIOTECHNOLOGY
- Nm-seq maps 2′-O-methylation sites in human mRNA with base precision
- (2017) Qing Dai et al. NATURE METHODS
- N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
- (2017) Yuri V. Svitkin et al. NUCLEIC ACIDS RESEARCH
- Our views of dynamic N 6 -methyladenosine RNA methylation
- (2017) Boxuan Simen Zhao et al. RNA
- Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey
- (2017) Maja Sedic et al. VETERINARY PATHOLOGY
- A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry
- (2017) Sylwia Walczak et al. Chemical Science
- Tools for translation: non-viral materials for therapeutic mRNA delivery
- (2017) Khalid A. Hajj et al. Nature Reviews Materials
- The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery
- (2016) Xinwei Cheng et al. ADVANCED DRUG DELIVERY REVIEWS
- Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
- (2016) Owen S. Fenton et al. ADVANCED MATERIALS
- Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
- (2016) James C. Kaczmarek et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthetically modified mRNA for efficient and fast human iPS cell generation and direct transdifferentiation to myoblasts
- (2016) David Preskey et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- mRNA-based therapeutics–Advances and perspectives
- (2016) O. V. Sergeeva et al. BIOCHEMISTRY-MOSCOW
- Cytoplasmic RNA decay pathways - Enzymes and mechanisms
- (2016) Anna Łabno et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Effects of Chemically Modified Messenger RNA on Protein Expression
- (2016) Bin Li et al. BIOCONJUGATE CHEMISTRY
- Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety
- (2016) Satoshi Uchida et al. BIOMATERIALS
- Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
- (2016) Kevin J. Kauffman et al. BIOMATERIALS
- Design, synthesis and biological evaluation of dinucleotide mRNA cap analog containing propargyl moiety
- (2016) Muthian Shanmugasundaram et al. BIOORGANIC & MEDICINAL CHEMISTRY
- CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells
- (2016) Xiaojuan Liu et al. CELL RESEARCH
- Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
- (2016) Jiangtao Ren et al. CLINICAL CANCER RESEARCH
- Pseudouridine: the fifth RNA nucleotide with renewed interests
- (2016) Xiaoyu Li et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways
- (2016) Man Li et al. JOURNAL OF CONTROLLED RELEASE
- Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
- (2016) Matthias A. Oberli et al. NANO LETTERS
- Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines
- (2016) Thomas Démoulins et al. Nanomedicine-Nanotechnology Biology and Medicine
- The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
- (2016) Dan Dominissini et al. NATURE
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- Generation of knockout mice by Cpf1-mediated gene targeting
- (2016) Yongsub Kim et al. NATURE BIOTECHNOLOGY
- Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome
- (2016) Xiaoyu Li et al. Nature Chemical Biology
- N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
- (2016) Junhong Choi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A general method for rapid and cost-efficient large-scale production of 5′ capped RNA
- (2016) Anna-Lisa Fuchs et al. RNA
- Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
- (2016) B. Delatte et al. SCIENCE
- RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling
- (2016) Ann Fiegen Durbin et al. mBio
- N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
- (2016) Junhong Choi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- 2′Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors
- (2016) Youngju Lee et al. Nucleic Acid Therapeutics
- Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification
- (2015) Lakshminarayan M. Iyer et al. BIOESSAYS
- 5′ UTR m6A Promotes Cap-Independent Translation
- (2015) Kate D. Meyer et al. CELL
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
- (2015) Oliwia Andries et al. JOURNAL OF CONTROLLED RELEASE
- Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code
- (2015) Thomas Philipp Hoernes et al. NUCLEIC ACIDS RESEARCH
- Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond
- (2015) Britta Vallazza et al. Wiley Interdisciplinary Reviews-RNA
- Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
- (2014) Jiaxi Wu et al. Annual Review of Immunology
- Zinc Finger Endonuclease TargetingPSIP1Inhibits HIV-1 Integration
- (2014) Roger Badia et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
- (2014) Schraga Schwartz et al. CELL
- Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
- (2014) Thomas M. Carlile et al. NATURE
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients
- (2013) S. Wilgenhof et al. ANNALS OF ONCOLOGY
- XRN 5′→3′ exoribonucleases: Structure, mechanisms and functions
- (2013) Vinay K. Nagarajan et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology
- (2013) Michael Kalos et al. IMMUNITY
- Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma
- (2013) Meenakshi Hegde et al. MOLECULAR THERAPY
- Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
- (2013) Lior Zangi et al. NATURE BIOTECHNOLOGY
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
- (2013) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- RNA pseudouridylation: new insights into an old modification
- (2013) Junhui Ge et al. TRENDS IN BIOCHEMICAL SCIENCES
- Successful Use of mRNA‐Nucleofection for Overexpression of Interleukin‐10 in Murine Monocytes/Macrophages for Anti‐inflammatory Therapy in a Murine Model of Autoimmune Myocarditis
- (2013) Oliver Zimmermann et al. Journal of the American Heart Association
- Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
- (2012) Benjamin Petsch et al. NATURE BIOTECHNOLOGY
- Nonviral delivery of self-amplifying RNA vaccines
- (2012) A. J. Geall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells
- (2011) David M. Barrett et al. HUMAN GENE THERAPY
- Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity
- (2011) C. Trumpfheller et al. JOURNAL OF INTERNAL MEDICINE
- The effect of neutral helper lipids on the structure of cationic lipid monolayers
- (2011) A. P. Dabkowska et al. Journal of the Royal Society Interface
- Nanoparticle PEGylation for imaging and therapy
- (2011) Jesse V Jokerst et al. Nanomedicine
- Genetic engineering of human pluripotent cells using TALE nucleases
- (2011) Dirk Hockemeyer et al. NATURE BIOTECHNOLOGY
- Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
- (2011) Michael S D Kormann et al. NATURE BIOTECHNOLOGY
- Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
- (2011) Roland Züst et al. NATURE IMMUNOLOGY
- Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L
- (2011) B. R. Anderson et al. NUCLEIC ACIDS RESEARCH
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
- (2010) Luigi Warren et al. Cell Stem Cell
- Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo
- (2010) A N Kuhn et al. GENE THERAPY
- A Short Pulse of IL-4 Delivered by DCs Electroporated With Modified mRNA Can Both Prevent and Treat Autoimmune Diabetes in NOD Mice
- (2010) Rémi J Creusot et al. MOLECULAR THERAPY
- Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients
- (2010) Susanne M Rittig et al. MOLECULAR THERAPY
- Synonymous but not the same: the causes and consequences of codon bias
- (2010) Joshua B. Plotkin et al. NATURE REVIEWS GENETICS
- Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications
- (2010) Malwina Strenkowska et al. NEW JOURNAL OF CHEMISTRY
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
- (2010) Bart R. Anderson et al. NUCLEIC ACIDS RESEARCH
- Locked Nucleic Acid (LNA)-Modified Dinucleotide mRNA Cap Analogue: Synthesis, Enzymatic Incorporation, and Utilization
- (2009) Anilkumar R. Kore et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
- (2009) Aron M. Geurts et al. SCIENCE
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
- A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
- (2008) Akin Akinc et al. NATURE BIOTECHNOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now