The RNA modification N6-methyladenosine as a novel regulator of the immune system

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

(2019) Mathieu Ringeard et al.   NATURE

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

(2019) Dali Han et al.   NATURE

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

(2019) R. Alexander Wesselhoeft et al.   MOLECULAR CELL

Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation

(2019) Heather Lee et al.   NATURE CELL BIOLOGY

Translate less, prime better, to improve anti-tumor responses

(2019) Marianne Burbage et al.   NATURE IMMUNOLOGY

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

(2019) Shiming Peng et al.   Science Translational Medicine

Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling

(2019) Miguel Angel Garcia-Campos et al.   CELL

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity

(2019) Akihiro Imaeda et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

(2019) Lei Wang et al.   SCIENCE

Regulation of Viral Infection by the RNA Modification N6-methyladenosine

(2019) Graham D. Williams et al.   Annual Review of Virology

Single-base mapping of m6A by an antibody-independent method

(2019) Zhang Zhang et al.   Science Advances

DART-seq: an antibody-free method for global m6A detection

(2019) Kate D. Meyer   NATURE METHODS

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication

(2019) Yang Liu et al.   SCIENCE

m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment

(2019) Yuanming Cheng et al.   Cell Reports

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

(2019) Verena Labi et al.   GENES & DEVELOPMENT

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base-specific resolution

(2019) Daniel A. Lorenz et al.   RNA

Accurate detection of m6A RNA modifications in native RNA sequences

(2019) Huanle Liu et al.   Nature Communications

m6A mRNA methylation sustains Treg suppressive functions

(2018) Jiyu Tong et al.   CELL RESEARCH

Mettl3–Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells

(2018) Qi Jason Yao et al.   CELL RESEARCH

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells

(2018) Zhihui Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N 6 -Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

(2018) Jun Zhou et al.   MOLECULAR CELL

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1

(2018) Jens Kretschmer et al.   RNA

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

(2018) Seth D. Kasowitz et al.   PLoS Genetics

A 360° view of circular RNAs: From biogenesis to functions

(2018) Jeremy E. Wilusz   Wiley Interdisciplinary Reviews-RNA

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

(2018) Devanshi Jain et al.   eLife

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion

(2018) Zhenrui Li et al.   CELL RESEARCH

Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration

(2018) Hu Wang et al.   CELL RESEARCH

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

The m6A-methylase complex recruits TREX and regulates mRNA export

(2018) Simon Lesbirel et al.   Scientific Reports

Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

(2018) Hanxiao Sun et al.   CELL RESEARCH

RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β

(2018) Rosa M. Rubio et al.   GENES & DEVELOPMENT

RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation

(2018) Yuan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

(2017) Shengdong Ke et al.   GENES & DEVELOPMENT

Writer's block: preventing m6 A mRNA methylation promotes T cell naivety

(2017) Jonathan Sprent et al.   IMMUNOLOGY AND CELL BIOLOGY

RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome

(2017) A. Emilia Arguello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of m 6 A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline

(2017) Magdalena Natalia Wojtas et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

(2017) Hua-Bing Li et al.   NATURE

m6A modulates haematopoietic stem and progenitor cell specification

(2017) Chunxia Zhang et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

Pre-mRNA processing includes N 6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics”

(2017) Robert B. Darnell et al.   RNA

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline

(2017) Alexis S Bailey et al.   eLife

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

Dynamics of Human and Viral RNA Methylation during Zika Virus Infection

(2016) Gianluigi Lichinchi et al.   Cell Host & Microbe

N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

(2016) Nandan S. Gokhale et al.   Cell Host & Microbe

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Dendritic cell maturation and cross-presentation: timing matters!

(2016) Andrés Alloatti et al.   IMMUNOLOGICAL REVIEWS

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

(2016) Ann Fiegen Durbin et al.   mBio

Structural insights into the molecular mechanism of the m6A writer complex

(2016) Paweł Śledź et al.   eLife

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition

(2015) Panpan Zhang et al.   CELL RESEARCH

A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation

(2015) Shengdong Ke et al.   GENES & DEVELOPMENT

Structural Basis for the Discriminative Recognition ofN6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins

(2015) Chao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

(2015) Bastian Linder et al.   NATURE METHODS

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation

(2015) Jennifer L. Hyde et al.   VIROLOGY

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition

(2015) Carlos O. Lizama et al.   Nature Communications

Notch signal strength controls cell fate in the haemogenic endothelium

(2015) Leonor Gama-Norton et al.   Nature Communications

Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue

(2014) Hai Qi et al.   Annual Review of Cell and Developmental Biology

The Pivotal Regulatory Landscape of RNA Modifications

(2014) Sheng Li et al.   Annual Review of Genomics and Human Genetics

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

(2014) Tingting Zhu et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition

(2014) Fudong Li et al.   CELL RESEARCH

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA

(2013) N. Liu et al.   RNA

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells

(2011) Ignacio Cebrian et al.   CELL

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells

(2011) Michal Rabani et al.   NATURE BIOTECHNOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Origin and development of dendritic cells

(2010) Kang Liu et al.   IMMUNOLOGICAL REVIEWS

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex

(2010) Linsey Reavie et al.   NATURE IMMUNOLOGY

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

(2009) Li-Fan Lu et al.   IMMUNITY

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

(2009) Douglas C. Palmer et al.   TRENDS IN IMMUNOLOGY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY