The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis

Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer

(2020) Wenting Dai et al.   BRITISH JOURNAL OF CANCER

Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer

(2020) Yanting You et al.   Frontiers in Pharmacology

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

(2019) Michael L.-H. Huang et al.   Oxidative Medicine and Cellular Longevity

The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria

(2019) Rong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

(2019) Claudia Contadini et al.   Cell Death & Disease

Cellular Stress Associated with Aneuploidy

(2018) Jin Zhu et al.   DEVELOPMENTAL CELL

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Aurora kinase A localises to mitochondria to control organelle dynamics and energy production

(2018) Giulia Bertolin et al.   eLife

Environmental stresses induce karyotypic instability in colorectal cancer cells

(2018) Zhihao Tan et al.   MOLECULAR BIOLOGY OF THE CELL

Oxidative stress induces mitotic arrest by inhibiting Aurora A-involved mitotic spindle formation

(2017) Guang-Fei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

(2017) Chenxia Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expanding perspectives on the significance of mitophagy in cancer

(2017) Lauren E. Drake et al.   SEMINARS IN CANCER BIOLOGY

Autophagy and the Cell Cycle: A Complex Landscape

(2017) Søs Grønbæk Mathiassen et al.   Frontiers in Oncology

Temporal depolarization of mitochondria during M phase

(2017) Kotoe Hirusaki et al.   Scientific Reports

The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson's Disease

(2016) Zhenzhen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca 2+ Homeostasis in Neural Stem Cell Development

(2016) Seongsoo Lee et al.   DEVELOPMENTAL CELL

Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation–induced apoptosis

(2016) Zhenzhen Zhang et al.   FASEB JOURNAL

Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients

(2016) Deepak Kumar Tanwar et al.   Oncotarget

Dynasore - not just a dynamin inhibitor

(2015) Giulio Preta et al.   Cell Communication and Signaling

AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1

(2015) Chia-Hua Chou et al.   CELL CYCLE

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

(2015) Elena Doménech et al.   NATURE CELL BIOLOGY

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

(2015) Marleen Forkink et al.   Redox Biology

Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis

(2014) Shashikiran Donthamsetty et al.   CELL CYCLE

A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1

(2014) Jingnan Wang et al.   Molecular Oncology

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Mitotic spindle multipolarity without centrosome amplification

(2014) Helder Maiato et al.   NATURE CELL BIOLOGY

Chromosomal instability and transcriptome dynamics in cancer

(2013) Joshua B. Stevens et al.   CANCER AND METASTASIS REVIEWS

Mitochondrial signaling contributes to disuse muscle atrophy

(2012) Scott K. Powers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

(2012) Glenn Marsboom et al.   CIRCULATION RESEARCH

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress

(2012) W. Qian et al.   JOURNAL OF CELL SCIENCE

The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery

(2012) J P H Chow et al.   ONCOGENE

GSK3beta-Mediated Drp1 Phosphorylation Induced Elongated Mitochondrial Morphology against Oxidative Stress

(2012) Chia-Hua Chou et al.   PLoS One

RALA and RALBP1 regulate mitochondrial fission at mitosis

(2011) David F. Kashatus et al.   NATURE CELL BIOLOGY

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1

(2011) Ronald A. Merrill et al.   PLOS BIOLOGY

Hypothesis: Bifunctional mitochondrial proteins have centrosomal functions

(2009) Akilah Moore et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE