A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease

Mitochondrial Kinases and the Role of Mitochondrial Protein Phosphorylation in Health and Disease

(2021) Veronika Kotrasová et al.   Life-Basel

A novel mitochondrial complex of P450c11AS, StAR and Tom22 synthesizes aldosterone in the rat heart

(2021) Himangshu S. Bose et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

DMT1 Inhibitors Kill Cancer Stem Cells by Blocking Lysosomal Iron Translocation

(2020) Andreea L. Turcu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay

(2020) Xiujuan Wei et al.   JOURNAL OF HUMAN GENETICS

Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

(2020) Stéphanie Herkenne et al.   Cell Metabolism

De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment

(2020) Debdeep Dutta et al.   HUMAN MOLECULAR GENETICS

TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels

(2020) Wookyeom Yang et al.   Cancers

Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases

(2020) Perla Pérez-Treviño et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

Tom70 protects against diabetic cardiomyopathy through its antioxidant and antiapoptotic properties

(2020) Peijian Wang et al.   HYPERTENSION RESEARCH

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

(2020) David E. Gordon et al.   SCIENCE

Atomic structure of human TOM core complex

(2020) Wenhe Wang et al.   Cell Discovery

Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells

(2020) Sharanpreet Hira et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

(2020) Briana R. De Miranda et al.   npj Parkinsons Disease

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

(2019) Haruka Sakaue et al.   MOLECULAR CELL

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

(2019) Shiori Sekine et al.   MOLECULAR CELL

The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1’s association with the mitochondrial protein TOM20

(2019) Conggang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells

(2019) Yi Zeng et al.   Oxidative Medicine and Cellular Longevity

BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites

(2019) Takushi Namba   Science Advances

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

(2019) Zhenyuan Tang et al.   Cell Reports

Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics

(2019) Yunxia Wang et al.   NUCLEIC ACIDS RESEARCH

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

(2019) Adam Bartok et al.   Nature Communications

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

(2019) M. Jacoupy et al.   Scientific Reports

Characterization of Factors Involved in Localized Translation Near Mitochondria by Ribosome-Proximity Labeling

(2019) Dikla Vardi-Oknin et al.   Frontiers in Cell and Developmental Biology

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy

(2018) Bojana Kravic et al.   Autophagy

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences

(2018) Sandra Backes et al.   JOURNAL OF CELL BIOLOGY

Mimivirus-Encoded Nucleotide Translocator VMC1 Targets the Mitochondrial Inner Membrane

(2018) Vincenzo Zara et al.   JOURNAL OF MOLECULAR BIOLOGY

UBX domain-containing proteins are involved in lipid homeostasis and stress responses in Pichia pastoris

(2017) Meng Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45

(2017) Xi Wu et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial BK Ca channel cardiac interactome reveals BK Ca association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator

(2017) Jin Zhang et al.   MITOCHONDRION

MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70

(2017) Qiang Xue et al.   Cell Death & Disease

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues

(2016) Maheshinie Rajapaksha et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases

(2016) Haifeng Pei et al.   Oxidative Medicine and Cellular Longevity

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

(2015) Fabienne C. Fiesel et al.   HUMAN MUTATION

Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria

(2015) Karin Waegemann et al.   JOURNAL OF MOLECULAR BIOLOGY

Tom70 Mediates Sendai Virus-Induced Apoptosis on Mitochondria

(2015) Bo Wei et al.   JOURNAL OF VIROLOGY

Direct Activation of Bax Protein for Cancer Therapy

(2015) Zhiqing Liu et al.   MEDICINAL RESEARCH REVIEWS

Mitochondrial biology: From molecules to diseases

(2015) Shama Prasada Kabekkodu et al.   MITOCHONDRION

Cryo-slicing Blue Native-Mass Spectrometry (csBN-MS), a Novel Technology for High Resolution Complexome Profiling

(2015) Catrin S. Müller et al.   MOLECULAR & CELLULAR PROTEOMICS

MitoFates: Improved Prediction of Mitochondrial Targeting Sequences and Their Cleavage Sites

(2015) Yoshinori Fukasawa et al.   MOLECULAR & CELLULAR PROTEOMICS

Probing the Biology of Giardia intestinalis Mitosomes UsingIn VivoEnzymatic Tagging

(2015) Eva Martincová et al.   MOLECULAR AND CELLULAR BIOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Molecular architecture of the active mitochondrial protein gate

(2015) T. Shiota et al.   SCIENCE

The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM)

(2015) Daniel O. Frank et al.   PLoS One

Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy

(2014) Jun Li et al.   CELL RESEARCH

Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)

(2014) Natascha A. Wolff et al.   FASEB JOURNAL

Mitochondrial protein translocases for survival and wellbeing

(2014) Anna Magdalena Sokol et al.   FEBS LETTERS

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria

(2014) Agnieszka Gornicka et al.   MOLECULAR BIOLOGY OF THE CELL

HIV-1 protease-induced apoptosis

(2014) Michaela Rumlová et al.   Retrovirology

Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space

(2014) Rakhi Bajaj et al.   STRUCTURE

Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

(2014) Takuma Yoshizumi et al.   Nature Communications

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance

(2013) Giulia Bertolin et al.   Autophagy

Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22

(2013) Valery G.Veresov et al.   CELLULAR SIGNALLING

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization, Design, and Function of the Mitochondrial Proteome: From Organs to Organisms

(2013) Christopher Lotz et al.   JOURNAL OF PROTEOME RESEARCH

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Tom70 Is Essential for PINK1 Import into Mitochondria

(2013) Hiroki Kato et al.   PLoS One

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

(2013) Andreas Bender et al.   PLoS One

ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network

(2013) L Feng et al.   Cell Death & Disease

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Proapoptotic Action of p53-Tom5 in p53-Resistant A549 Human Non-small Cell Lung Cancer Cells through Direct Mitochondrial Dysfunction

(2011) Takuya Umemoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Regulation of Mitochondrial Protein Import by Cytosolic Kinases

(2011) Oliver Schmidt et al.   CELL

The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast

(2011) Thibaud T. Renault et al.   FEBS LETTERS

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Developmental Control of Apoptosis by the Immunophilin Aryl Hydrocarbon Receptor-interacting Protein (AIP) Involves Mitochondrial Import of the Survivin Protein

(2011) Byoung Heon Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response

(2011) Takashi Takano et al.   JOURNAL OF MEDICAL VIROLOGY

Functional Refolding and Characterization of Two Tom40 Isoforms from Human Mitochondria

(2011) Frauke Mager et al.   JOURNAL OF MEMBRANE BIOLOGY

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

(2011) Xinguo Qian et al.   JOURNAL OF MOLECULAR BIOLOGY

Saccharomyces Genome Database: the genomics resource of budding yeast

(2011) J. M. Cherry et al.   NUCLEIC ACIDS RESEARCH

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

(2010) Xin-Yi Liu et al.   CELL RESEARCH

The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model

(2010) S. Curado et al.   Disease Models & Mechanisms

Assembly of the Mitochondrial Protein Import Channel

(2010) Thomas Becker et al.   MOLECULAR BIOLOGY OF THE CELL

Helicobacter pylori VacA Toxin/Subunit p34: Targeting of an Anion Channel to the Inner Mitochondrial Membrane

(2010) Grażyna Domańska et al.   PLoS Pathogens

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Molecular Chaperone Hsp70/Hsp90 Prepares the Mitochondrial Outer Membrane Translocon Receptor Tom71 for Preprotein Loading

(2009) Jingzhi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Organization of the Monomeric Form of the Tom70 Mitochondrial Import Receptor

(2009) Ryan D. Mills et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic and Functional Interactions between the Mitochondrial Outer Membrane Proteins Tom6 and Sam37

(2009) J. Dukanovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane

(2008) Hiroki Kato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bax inserts into the mitochondrial outer membrane by different mechanisms

(2008) Pierre-François Cartron et al.   FEBS LETTERS

Cryo-Electron Microscopy Structure of a Yeast Mitochondrial Preprotein Translocase

(2008) Kirstin Model et al.   JOURNAL OF MOLECULAR BIOLOGY

The Peripheral Membrane Subunits of the SAM Complex Function Codependently in Mitochondrial Outer Membrane Biogenesis

(2007) Nickie C. Chan et al.   MOLECULAR BIOLOGY OF THE CELL