标题
“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”
作者
关键词
Ghrelin, GHSR, LEAP2, GOAT, Obesity, Diabetes
出版物
Molecular Metabolism
Volume 46, Issue -, Pages 101128
出版商
Elsevier BV
发表日期
2020-11-25
DOI
10.1016/j.molmet.2020.101128
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a
- (2020) Alix A. J. Rouault et al. Science Signaling
- Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways
- (2020) Haiming Liu et al. Oncotarget
- Metabolic insights from a GHSR-A203E mutant mouse model
- (2020) Lola J. Torz et al. Molecular Metabolism
- Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus
- (2020) Kripa Shankar et al. Frontiers in Endocrinology
- Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice
- (2019) Fei Fang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ghrelin Regulation of Glucose Metabolism
- (2019) Sarah. M. Gray et al. JOURNAL OF NEUROENDOCRINOLOGY
- Identifying the binding mechanism of LEAP2 to receptor GHSR1a
- (2019) Jia-Hui Wang et al. FEBS Journal
- Prader‐Willi syndrome: A model for understanding the ghrelin system
- (2019) Maithé Tauber et al. JOURNAL OF NEUROENDOCRINOLOGY
- Ghrelin and food reward
- (2019) Omar Al Massadi et al. NEUROPHARMACOLOGY
- LEAP2 changes with body mass and food intake in humans and mice
- (2019) Bharath K. Mani et al. JOURNAL OF CLINICAL INVESTIGATION
- Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease
- (2019) Jing Tian et al. Science Translational Medicine
- Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease
- (2019) Luke Buntwal et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Acyl-ghrelin is Permissive for the Normal Counterregulatory Response to Insulin-induced Hypoglycemia
- (2019) Kripa Shankar et al. DIABETES
- LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor
- (2018) Xuecai Ge et al. Cell Metabolism
- Hypothalamic loss of Snord116 and Prader-Willi syndrome hyperphagia: the buck stops here?
- (2018) Juan A. Rodriguez et al. JOURNAL OF CLINICAL INVESTIGATION
- AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial
- (2018) Soraya Allas et al. PLoS One
- Ghrelin mediates exercise endurance and the feeding response post-exercise
- (2018) Bharath K. Mani et al. Molecular Metabolism
- Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans
- (2018) Laura C. Page et al. DIABETES
- N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor
- (2018) Céline M’Kadmi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice
- (2018) Chia-Shan Wu et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Translating biased signaling in the ghrelin receptor system into differential in vivo functions
- (2018) Franziska Mende et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand
- (2017) Alexander Edwards et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis
- (2017) V P Chen et al. INTERNATIONAL JOURNAL OF OBESITY
- Effects of intensive training on menstrual function and certain serum hormones and peptides related to the female reproductive system
- (2017) Geum Joon Cho et al. MEDICINE
- Individual Variation in Hunger, Energy Intake, and Ghrelin Responses to Acute Exercise
- (2017) JAMES A. KING et al. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
- Ghrelin as a Survival Hormone
- (2017) Bharath K. Mani et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- MRAP2 regulates ghrelin receptor signaling and hunger sensing
- (2017) Dollada Srisai et al. Nature Communications
- Very Low Volume Sprint Interval Exercise Suppresses Subjective Appetite, Lowers Acylated Ghrelin, and Elevates GLP-1 in Overweight Individuals: A Pilot Study
- (2017) Adrian Holliday et al. Nutrients
- The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting
- (2017) Bharath K. Mani et al. Molecular Metabolism
- Ghrelin-Reactive Immunoglobulins in Conditions of Altered Appetite and Energy Balance
- (2017) Sergueï O. Fetissov et al. Frontiers in Endocrinology
- Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity
- (2016) Jong Han Lee et al. DIABETES
- Safety, tolerability, pharmacokinetics and pharmacodynamics of AZP-531, a first-in-class analogue of unacylated ghrelin, in healthy and overweight/obese subjects and subjects with type 2 diabetes
- (2016) S. Allas et al. DIABETES OBESITY & METABOLISM
- Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets
- (2016) Alice E. Adriaenssens et al. DIABETOLOGIA
- Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1
- (2016) Jenny Tong et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome
- (2016) Lisa C. Burnett et al. JOURNAL OF CLINICAL INVESTIGATION
- β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals
- (2016) Bharath K. Mani et al. JOURNAL OF CLINICAL INVESTIGATION
- Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men
- (2016) David R Broom et al. JOURNAL OF ENDOCRINOLOGY
- High unacylated ghrelin levels support the concept of anorexia in infants with prader-willi syndrome
- (2016) Veronique Beauloye et al. Orphanet Journal of Rare Diseases
- Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner
- (2016) Amanda K.E. Hornsby et al. PSYCHONEUROENDOCRINOLOGY
- Obesity Impairs the Action of the Neuroendocrine Ghrelin System
- (2016) Jeffrey M. Zigman et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets
- (2016) Michael R. DiGruccio et al. Molecular Metabolism
- Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)–Deficient Mice
- (2015) François Brial et al. DIABETES
- A Strong Stomach for Somatostatin
- (2015) Bharath K. Mani et al. ENDOCRINOLOGY
- Circulating acylghrelin levels are suppressed by insulin and increase in response to hypoglycemia in healthy adult volunteers
- (2015) E. S. Lauritzen et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Neonatal ghrelin programs development of hypothalamic feeding circuits
- (2015) Sophie M. Steculorum et al. JOURNAL OF CLINICAL INVESTIGATION
- Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
- (2015) Farhana Naznin et al. JOURNAL OF ENDOCRINOLOGY
- Ghrelin Signalling on Food Reward: A Salient Link Between the Gut and the Mesolimbic System
- (2015) M. Perello et al. JOURNAL OF NEUROENDOCRINOLOGY
- Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone
- (2015) Yuanyuan Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study
- (2015) Cristiane Moraes et al. RENAL FAILURE
- Ghrelin
- (2015) T.D. Müller et al. Molecular Metabolism
- Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia
- (2014) Frederick A. Kweh et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet
- (2014) Matthew R. McFarlane et al. Cell Metabolism
- MECHANISMS IN ENDOCRINOLOGY: Regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions
- (2014) Kristy M Heppner et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Obestatin Levels Are Associated With C-Peptide and Antiinsulin Antibodies at the Onset, Whereas Unacylated and Acylated Ghrelin Levels Are Not Predictive of Long-Term Metabolic Control in Children With Type 1 Diabetes
- (2014) Flavia Prodam et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Ghrelin Receptor Regulates Appetite and Satiety during Aging in Mice by Regulating Meal Frequency and Portion Size but Not Total Food Intake
- (2014) Ligen Lin et al. JOURNAL OF NUTRITION
- Ghrelin administered spinally increases the blood glucose level in mice
- (2014) Yun-Beom Sim et al. PEPTIDES
- Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects
- (2013) Esben Thyssen Vestergaard et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Calorie-Restricted Weight Loss Reverses High-Fat Diet-Induced Ghrelin Resistance, Which Contributes to Rebound Weight Gain in a Ghrelin-Dependent Manner
- (2013) Dana I. Briggs et al. ENDOCRINOLOGY
- Derangement of ghrelin secretion after long-term high-fat diet feeding in rats
- (2013) Aya Sugiishi et al. HEPATOLOGY RESEARCH
- Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models
- (2013) Aki Uchida et al. Frontiers in Neuroscience
- Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin
- (2013) Qian Wang et al. Molecular Metabolism
- Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice
- (2012) Xiaojun Ma et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The influence of vigorous running and cycling exercise on hunger perceptions and plasma acylated ghrelin concentrations in lean young men
- (2012) Lucy K. Wasse et al. Applied Physiology Nutrition and Metabolism
- Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling
- (2012) Scott E. Kanoski et al. BIOLOGICAL PSYCHIATRY
- The glucagon-like peptide-1 analog liraglutide suppresses ghrelin and controls diabetes in a patient with Prader-Willi syndrome
- (2012) Miho Senda et al. ENDOCRINE JOURNAL
- Prader-Willi syndrome
- (2012) Suzanne B. Cassidy et al. GENETICS IN MEDICINE
- GOAT induced ghrelin acylation regulates hedonic feeding
- (2012) J.F. Davis et al. HORMONES AND BEHAVIOR
- Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids
- (2012) Robert Lin Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling
- (2012) Harriët Schellekens et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Approach to the Child with Prader-Willi Syndrome
- (2012) Jennifer L. Miller JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism
- (2012) Andras Kern et al. NEURON
- Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling
- (2012) Angela K. Walker et al. PHYSIOLOGY & BEHAVIOR
- Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
- (2012) Michael M. Scott et al. PLoS One
- Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
- (2011) Ligen Lin et al. AGING CELL
- Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors
- (2011) Anne Rediger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ghrelin mediates stress-induced food-reward behavior in mice
- (2011) Jen-Chieh Chuang et al. JOURNAL OF CLINICAL INVESTIGATION
- Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells
- (2011) Jen-Chieh Chuang et al. MOLECULAR ENDOCRINOLOGY
- In adults with Prader–Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels
- (2011) Louise Purtell et al. NEUROPEPTIDES
- Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
- (2011) N Fujitsuka et al. Translational Psychiatry
- Influence of prolonged treadmill running on appetite, energy intake and circulating concentrations of acylated ghrelin
- (2010) James A. King et al. APPETITE
- Ghrelin increases intake of rewarding food in rodents
- (2010) Emil Egecioglu et al. ADDICTION BIOLOGY
- Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans
- (2010) J. Tong et al. DIABETES
- Identification and Characterization of Acyl-Protein Thioesterase 1/Lysophospholipase I As a Ghrelin Deacylation/Lysophospholipid Hydrolyzing Enzyme in Fetal Bovine Serum and Conditioned Medium
- (2010) Motoyasu Satou et al. ENDOCRINOLOGY
- Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons
- (2010) Dana I. Briggs et al. ENDOCRINOLOGY
- Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats
- (2010) Ya-Wen Hsu et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- The Hyperphagic Effect of Ghrelin Is Inhibited in Mice by a Diet High in Fat
- (2010) James V. Gardiner et al. GASTROENTEROLOGY
- Metabolic Status Regulates Ghrelin Function on Energy Homeostasis
- (2010) Dana I. Briggs et al. NEUROENDOCRINOLOGY
- Systemic ghrelin and reward: Effect of cholinergic blockade
- (2010) E. Disse et al. PHYSIOLOGY & BEHAVIOR
- Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
- (2010) T.-J. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The effect of exercise intensity on plasma and tissue acyl ghrelin concentrations in fasted rats
- (2010) Rozita Fathi et al. REGULATORY PEPTIDES
- Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor
- (2010) B. P. Barnett et al. SCIENCE
- Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
- (2009) Mario Perello et al. BIOLOGICAL PSYCHIATRY
- Children with Prader–Willi syndrome exhibit more evident meal-induced responses in plasma ghrelin and peptide YY levels than obese and lean children
- (2009) Carla Bizzarri et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- GOAT links dietary lipids with the endocrine control of energy balance
- (2009) Henriette Kirchner et al. NATURE MEDICINE
- Is desacyl ghrelin a modulator of food intake?
- (2009) Tobias Inhoff et al. PEPTIDES
- Characterization of a novel ghrelin cell reporter mouse
- (2009) Ichiro Sakata et al. REGULATORY PEPTIDES
- Mice with chronically increased circulating ghrelin develop age-related glucose intolerance
- (2008) Jacquelyn A. Reed et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus?
- (2008) Hajime Ariga et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
- (2008) Jing Yang et al. CELL
- Role of Ghrelin in the Relationship Between Hyperphagia and Accelerated Gastric Emptying in Diabetic Mice
- (2008) Pieter–Jan Verhulst et al. GASTROENTEROLOGY
- Acyl and Total Ghrelin Are Suppressed Strongly by Ingested Proteins, Weakly by Lipids, and Biphasically by Carbohydrates
- (2008) Karen E. Foster-Schubert et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Hyperghrelinemia Precedes Obesity in Prader-Willi Syndrome
- (2008) Eva Feigerlová et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men
- (2008) Jianhua Liu et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats
- (2008) Tobias Inhoff et al. PEPTIDES
- Ghrelin octanoylation mediated by an orphan lipid transferase
- (2008) J. A. Gutierrez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice
- (2008) Kenneth A. Longo et al. REGULATORY PEPTIDES
- Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
- (2007) Paul T. Pfluger et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance
- (2007) Yuxiang Sun et al. ENDOCRINOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More