Safety, tolerability, pharmacokinetics and pharmacodynamics of AZP-531, a first-in-class analogue of unacylated ghrelin, in healthy and overweight/obese subjects and subjects with type 2 diabetes

Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice

(2015) Bjorn T. Tam et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Acute Administration of Unacylated Ghrelin Has No Effect on Basal or Stimulated Insulin Secretion in Healthy Humans

(2014) J. Tong et al.   DIABETES

Unacylated Ghrelin Induces Oxidative Stress Resistance in a Glucose Intolerance and Peripheral Artery Disease Mouse Model by Restoring Endothelial Cell miR-126 Expression

(2014) Gabriele Togliatto et al.   DIABETES

Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

(2013) Behiye Özcan et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis

(2013) Patric J. D. Delhanty et al.   FASEB JOURNAL

Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans

(2012) A. Benso et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues

(2012) Michel Julien et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Des-Acyl Ghrelin Fragments and Analogues Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets and Prevent Diabetes in Streptozotocin-Treated Rats

(2012) Riccarda Granata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unacylated Ghrelin Rescues Endothelial Progenitor Cell Function in Individuals With Type 2 Diabetes

(2010) G. Togliatto et al.   DIABETES

Des-Acyl Ghrelin Has Specific Binding Sites and Different Metabolic Effects from Ghrelin in Cardiomyocytes

(2010) Pamela V. Lear et al.   ENDOCRINOLOGY

Unacylated Ghrelin Rapidly Modulates Lipogenic and Insulin Signaling Pathway Gene Expression in Metabolically Active Tissues of GHSR Deleted Mice

(2010) Patric J. D. Delhanty et al.   PLoS One

Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin

(2010) Rajesh Kumar et al.   REGULATORY PEPTIDES

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes

(2009) Rosalie M Kiewiet et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Effect of Des-acyl Ghrelin on Adiposity and Glucose Metabolism

(2008) Weizhen Zhang et al.   ENDOCRINOLOGY

Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats

(2008) Tobias Inhoff et al.   PEPTIDES

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA