Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand

Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity

(2016) Jong Han Lee et al.   DIABETES

Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates

(2016) Kayleigh R. McGovern-Gooch et al.   ENDOCRINOLOGY

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons

(2016) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin-Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin

(2016) G. Fernandez et al.   JOURNAL OF NEUROENDOCRINOLOGY

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward

(2016) Rahul Pandit et al.   NEUROPSYCHOPHARMACOLOGY

Investigation of a role for ghrelin signaling in binge-like feeding in mice under limited access to high-fat diet

(2016) S.J. King et al.   NEUROSCIENCE

Driving the need to feed: Insight into the collaborative interaction between ghrelin and endocannabinoid systems in modulating brain reward systems

(2016) Alexander Edwards et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice

(2015) Petra Suchankova et al.   ALCOHOL AND ALCOHOLISM

Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor

(2015) Andras Kern et al.   CELL

Ghrelin Receptor Ligands Reaching Clinical Trials: From Peptides to Peptidomimetics; from Agonists to Antagonists

(2015) M. Vodnik et al.   HORMONE AND METABOLIC RESEARCH

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons

(2015) Eduardo Javier López Soto et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ghrelin regulates phasic dopamine and nucleus accumbens signaling evoked by food-predictive stimuli

(2015) Jackson J. Cone et al.   JOURNAL OF NEUROCHEMISTRY

Heterodimer-specific signaling

(2015) Marc Parmentier   Nature Chemical Biology

Dual agonist occupancy of AT1-R–α2C-AR heterodimers results in atypical Gs-PKA signaling

(2015) Morgane Bellot et al.   Nature Chemical Biology

Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding

(2015) Eoin C. O’Connor et al.   NEURON

Knockdown of central ghrelin O-acyltransferase by vivo-morpholino reduces body mass of rats fed a high-fat diet

(2015) Martin Wellman et al.   PEPTIDES

Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food

(2014) Anthony P Goldstone et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Ghrelin accelerates synapse formation and activity development in cultured cortical networks

(2014) Irina I Stoyanova et al.   BMC NEUROSCIENCE

Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet

(2014) Matthew R. McFarlane et al.   Cell Metabolism

The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation

(2014) Yue Yin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse

(2014) Bharath K. Mani et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Divergent Neuronal Circuitries Underlying Acute Orexigenic Effects of Peripheral or Central Ghrelin: Critical Role of Brain Accessibility

(2014) A. Cabral et al.   JOURNAL OF NEUROENDOCRINOLOGY

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

(2014) Norman R. Saunders et al.   Frontiers in Neuroscience

Apo-Ghrelin Receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain

(2014) Andras Kern et al.   Frontiers in Endocrinology

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects

(2013) Jenny Tong et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Heterodimerization with Its Splice Variant Blocks the Ghrelin Receptor 1a in a Non-signaling Conformation

(2013) Sophie Mary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

(2013) Fanny Langlet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake

(2013) Karolina P. Skibicka et al.   NEUROPHARMACOLOGY

Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid

(2013) A. Cabral et al.   NEUROSCIENCE

Circumventricular organs: Targets for integration of circulating fluid and energy balance signals?

(2013) Andrea Mimee et al.   PHYSIOLOGY & BEHAVIOR

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

(2013) Marie Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic control of energy balance: insights into the role of synaptic plasticity

(2013) Marcelo O. Dietrich et al.   TRENDS IN NEUROSCIENCES

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

(2013) Matei Bolborea et al.   TRENDS IN NEUROSCIENCES

Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward

(2013) Harriët Schellekens et al.   Frontiers in Neuroscience

Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models

(2013) Aki Uchida et al.   Frontiers in Neuroscience

Fasting levels of ghrelin covary with the brain response to food pictures

(2012) Nils B. Kroemer et al.   ADDICTION BIOLOGY

Design, Evaluation, and Comparison of Ghrelin Receptor Agonists and Inverse Agonists as Suitable Radiotracers for PET Imaging

(2012) Constance Chollet et al.   BIOCONJUGATE CHEMISTRY

The Role of Ghrelin in Reward-Based Eating

(2012) Mario Perelló et al.   BIOLOGICAL PSYCHIATRY

Brain Meets Body: The Blood-Brain Barrier as an Endocrine Interface

(2012) William A. Banks   ENDOCRINOLOGY

Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling

(2012) Harriët Schellekens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Aromatic Region To Induce a Switch between Agonism and Inverse Agonism at the Ghrelin Receptor

(2012) Sylvia Els et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gastric vagal afferent modulation by leptin is influenced by food intake status

(2012) Stephen J. Kentish et al.   JOURNAL OF PHYSIOLOGY-LONDON

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

(2012) Kevin W Williams et al.   NATURE NEUROSCIENCE

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

(2012) Andras Kern et al.   NEURON

Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system

(2012) Yukie Kawahara et al.   NEUROPHARMACOLOGY

Ghrelin signalling and obesity: At the interface of stress, mood and food reward

(2012) Harriët Schellekens et al.   PHARMACOLOGY & THERAPEUTICS

Ghrelin Expression in the Mouse Pancreas Defines a Unique Multipotent Progenitor Population

(2012) Luis Arnes et al.   PLoS One

Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression

(2011) Karolina P. Skibicka et al.   ADDICTION BIOLOGY

Scheduled feeding results in adipogenesis and increased acylated ghrelin

(2011) I. Verbaeys et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus

(2011) Paul J. Currie et al.   BEHAVIOURAL BRAIN RESEARCH

The expression of ghrelin O-acyltransferase (GOAT) in human tissues

(2011) Chung Thong Lim et al.   ENDOCRINE JOURNAL

Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

(2011) S.J. King et al.   HORMONES AND BEHAVIOR

Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors

(2011) Anne Rediger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Constitutive Activity Is an Intrinsic Feature of Ghrelin Receptor Protein

(2011) Marjorie Damian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin mediates stress-induced food-reward behavior in mice

(2011) Jen-Chieh Chuang et al.   JOURNAL OF CLINICAL INVESTIGATION

Diet-induced adaptation of vagal afferent function

(2011) Stephen Kentish et al.   JOURNAL OF PHYSIOLOGY-LONDON

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

Investigation of the presence of ghrelin in the central nervous system of the rat and mouse

(2011) J.B. Furness et al.   NEUROSCIENCE

6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior

(2011) Zachary Y. Weinberg et al.   NEUROSCIENCE LETTERS

Physiological roles of preproghrelin-derived peptides in GH secretion and feeding

(2011) Philippe Zizzari et al.   PEPTIDES

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

The Ghrelin Signalling System Is Involved in the Consumption of Sweets

(2011) Sara Landgren et al.   PLoS One

Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task

(2011) Beate C. Finger et al.   PSYCHOPHARMACOLOGY

Design and characterization of a fluorescent ghrelin analog for imaging the growth hormone secretagogue receptor 1a

(2011) Rebecca McGirr et al.   REGULATORY PEPTIDES

Ghrelin increases intake of rewarding food in rodents

(2010) Emil Egecioglu et al.   ADDICTION BIOLOGY

Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa

(2010) Andreas Stengel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acylated and unacylated ghrelin binding to membranes and to ghrelin receptor: Towards a better understanding of the underlying mechanisms

(2010) Edith Staes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Unraveling the role of the ghrelin gene peptides in the endocrine pancreas

(2010) Riccarda Granata et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Modulatory role of serotonin on feeding behavior

(2010) Carolina Peixoto Magalhães et al.   NUTRITIONAL NEUROSCIENCE

The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

(2010) Esteban M. Rodríguez et al.   PEPTIDES

Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization

(2010) Paul J. Currie et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content

(2010) Emmanuel Disse et al.   PHYSIOLOGY & BEHAVIOR

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

(2010) Elisabet Jerlhag et al.   PSYCHOPHARMACOLOGY

Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity

(2010) Zivjena Vucetic et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Ghrelin modulates electrical activity of area postrema neurons

(2009) Mark Fry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Ghrelin in Central Neurons

(2009) F. Ferrini et al.   Current Neuropharmacology

Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus

(2009) Philippe Ciofi et al.   ENDOCRINOLOGY

In VivoCharacterization of High Basal Signaling from the Ghrelin Receptor

(2009) Pia Steen Petersen et al.   ENDOCRINOLOGY

Gastrointestinal hormone actions in the central regulation of energy metabolism: potential sensory roles for the circumventricular organs

(2009) T D Hoyda et al.   INTERNATIONAL JOURNAL OF OBESITY

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain

(2009) Amandine Mullier et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Ghrelin and Dopamine: New Insights on the Peripheral Regulation of Appetite

(2009) Alfonso Abizaid   JOURNAL OF NEUROENDOCRINOLOGY

Relationship among Brain and Blood Glucose Levels and Spontaneous and Glucoprivic Feeding

(2009) A. A. Dunn-Meynell et al.   JOURNAL OF NEUROSCIENCE

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach

(2009) Manuel D. Gahete et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein G o1 by the Ghrelin Receptor

(2009) K. A. Bennett et al.   MOLECULAR PHARMACOLOGY

GOAT links dietary lipids with the endocrine control of energy balance

(2009) Henriette Kirchner et al.   NATURE MEDICINE

Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding

(2009) Haruaki Kageyama et al.   NEUROPEPTIDES

Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation

(2009) Anne Rediger et al.   Obesity Facts

Central administration of obestatin fails to show inhibitory effects on food and water intake in mice

(2009) Van Dijck Annemie et al.   REGULATORY PEPTIDES

Characterization of a novel ghrelin cell reporter mouse

(2009) Ichiro Sakata et al.   REGULATORY PEPTIDES

Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract, but not in the arcuate or paraventricular nuclei of the hypothalamus

(2008) Lucy F. Faulconbridge et al.   BRAIN RESEARCH

Peripheral injection of ghrelin induces Fos expression in the dorsomedial hypothalamic nucleus in rats

(2008) Peter Kobelt et al.   BRAIN RESEARCH

Autoradiographic analysis of ghrelin receptors in the rat hypothalamus

(2008) Joanne A. Harrold et al.   BRAIN RESEARCH

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

(2008) Kristin A. Anderson et al.   Cell Metabolism

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

(2008) Saima Malik et al.   Cell Metabolism

Protein components of the blood–brain barrier (BBB) in the mediobasal hypothalamus

(2008) Ebba Norsted et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functions

(2008) László Szidonya et al.   JOURNAL OF ENDOCRINOLOGY

Role of AMP-Activated Protein Kinase in the Control of Appetite

(2008) B. Kola   JOURNAL OF NEUROENDOCRINOLOGY

Pulsatile Cerebrospinal Fluid and Plasma Ghrelin in Relation to Growth Hormone Secretion and Food Intake in the Sheep

(2008) D. Grouselle et al.   JOURNAL OF NEUROENDOCRINOLOGY

Glial-Gonadotrophin Hormone (GnRH) Neurone Interactions in the Median Eminence and the Control of GnRH Secretion

(2008) S. R. Ojeda et al.   JOURNAL OF NEUROENDOCRINOLOGY

The Melanocortin-3 Receptor Is Required for Entrainment to Meal Intake

(2008) G. M. Sutton et al.   JOURNAL OF NEUROSCIENCE

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

(2008) Michael Lutter et al.   NATURE NEUROSCIENCE

Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats

(2008) Tobias Inhoff et al.   PEPTIDES

Electrophysiological effects of ghrelin on pedunculopontine tegmental neurons in rats: An in vitro study

(2008) Juhyon Kim et al.   PEPTIDES

Differential leptin access into the brain — A hierarchical organization of hypothalamic leptin target sites?

(2008) Heike Münzberg   PHYSIOLOGY & BEHAVIOR

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The blood-brain barrier: Connecting the gut and the brain

(2008) William A. Banks   REGULATORY PEPTIDES

Brain circuits regulating energy homeostasis

(2008) Alfonso Abizaid et al.   REGULATORY PEPTIDES

Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions

(2008) M MILLAN et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure

(2007) Paul T. Pfluger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

(2007) Daisuke Kohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serotonin 5-HT2CReceptor Agonist Promotes Hypophagia via Downstream Activation of Melanocortin 4 Receptors

(2007) Daniel D. Lam et al.   ENDOCRINOLOGY

Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression

(2007) Michelle Lee et al.   PEPTIDES

Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice

(2007) Haruaki Kageyama et al.   REGULATORY PEPTIDES

Synaptic relationships between proopiomelanocortin- and ghrelin-containing neurons in the rat arcuate nucleus

(2007) Jian-Lian Guan et al.   REGULATORY PEPTIDES