Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
出版年份 2021 全文链接
标题
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
作者
关键词
antiviral, entry, coronavirus, TMPRSS2, cyclosporin, cyclophilin, screening, HTS, drugs, SARS2
出版物
Cell Reports
Volume 35, Issue 1, Pages 108959
出版商
Elsevier BV
发表日期
2021-03-24
DOI
10.1016/j.celrep.2021.108959
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
- (2021) Emma S. Winkler et al. CELL
- Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- (2020) Manli Wang et al. CELL RESEARCH
- A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
- (2020) Xiaolong Tian et al. Emerging Microbes & Infections
- Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses
- (2020) Michael Letko et al. Nature Microbiology
- Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs
- (2020) Sangeun Jeon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
- (2020) Yixuan J. Hou et al. CELL
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model
- (2020) Hua-Hao Fan et al. CHINESE MEDICAL JOURNAL
- IL-6: Relevance for immunopathology of SARS-CoV-2
- (2020) E.O. Gubernatorova et al. CYTOKINE & GROWTH FACTOR REVIEWS
- COVID-19 and Calcineurin Inhibitors: Should They Get Left Out in the Storm?
- (2020) Michelle Willicombe et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cell entry mechanisms of SARS-CoV-2
- (2020) Jian Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
- (2020) Shutoku Matsuyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cytokine release syndrome in severe COVID-19
- (2020) John B. Moore et al. SCIENCE
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- (2020) Timothy P. Sheahan et al. Science Translational Medicine
- Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
- (2020) Xiuyuan Ou et al. Nature Communications
- Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
- (2020) Jia Liu et al. Cell Discovery
- COVID-19 Pandemic: Time to Revive the Cyclophilin Inhibitor Alisporivir
- (2020) Jean-Michel Pawlotsky CLINICAL INFECTIOUS DISEASES
- A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
- (2020) David R. Boulware et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ongoing Clinical Trials for the Management of the COVID-19 Pandemic
- (2020) Mark P. Lythgoe et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Potential Antiviral Options against SARS-CoV-2 Infection
- (2020) Aleksandr Ianevski et al. Viruses-Basel
- Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements
- (2020) Abhjieet Pandey et al. LIFE SCIENCES
- Genetic mechanisms of critical illness in Covid-19
- (2020) Erola Pairo-Castineira et al. NATURE
- Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells
- (2019) Yunsheng Zhang et al. BMC CANCER
- Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization
- (2019) Masashi Iwamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cepharanthine: An update of its mode of action, pharmacological properties and medical applications
- (2019) Christian Bailly PHYTOMEDICINE
- Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells
- (2019) Anjali Jacob et al. Nature Protocols
- Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells
- (2019) Kim et al. Biomolecules
- Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication
- (2019) Yue Ma-Lauer et al. ANTIVIRAL RESEARCH
- Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- (2018) Jiang Jiang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells
- (2018) Jean Kaoru Millet et al. VIROLOGY
- Epidermal growth factor receptor is a co-factor for transmissible gastroenteritis virus entry
- (2018) Weiwei Hu et al. VIROLOGY
- Targeting the Ca2+/Calmodulin-dependent protein kinase II by Tetrandrine in human liver cancer cells
- (2018) Tracy Huang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function
- (2018) Yejin Jang et al. JOURNAL OF VIROLOGY
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- Origin and evolution of pathogenic coronaviruses
- (2018) Jie Cui et al. NATURE REVIEWS MICROBIOLOGY
- Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B
- (2017) Yoshikazu Tanaka et al. JOURNAL OF GENERAL VIROLOGY
- Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus
- (2017) Keiko Rausch et al. Cell Reports
- Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses
- (2017) Laurent Meertens et al. Cell Reports
- Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
- (2016) Travis K. Warren et al. NATURE
- SARS and MERS: recent insights into emerging coronaviruses
- (2016) Emmie de Wit et al. NATURE REVIEWS MICROBIOLOGY
- Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
- (2015) Yasuteru Sakurai et al. SCIENCE
- Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis
- (2015) Jean Kaoru Millet et al. VIRUS RESEARCH
- Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication
- (2015) Albrecht von Brunn et al. Current Opinion in Virology
- Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection
- (2014) Julie Dyall et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cyclophilin inhibition as potential therapy for liver diseases
- (2014) Nikolai V. Naoumov JOURNAL OF HEPATOLOGY
- Viruses exploit the function of epidermal growth factor receptor
- (2014) Kai Zheng et al. REVIEWS IN MEDICAL VIROLOGY
- Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir
- (2014) Javier Carbajo-Lozoya et al. VIRUS RESEARCH
- Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells
- (2013) Jaganmohan Reddy Jangamreddy et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon- treatment
- (2013) A. H. de Wilde et al. JOURNAL OF GENERAL VIROLOGY
- Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486
- (2013) B. M. Dolan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclophilin A and viral infections
- (2012) Daijun Zhou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hepatocytes That Express Variants of Cyclophilin A Are Resistant to HCV Infection and Replication
- (2012) Thomas von Hahn et al. GASTROENTEROLOGY
- Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain
- (2012) Martha Schneider et al. JOURNAL OF VIROLOGY
- Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry
- (2012) J. Diao et al. JOURNAL OF VIROLOGY
- Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein
- (2012) Xiaoling Liu et al. PLoS One
- Cyclosporin A Inhibits the Influenza Virus Replication through Cyclophilin A-Dependent and -Independent Pathways
- (2012) Xiaoling Liu et al. PLoS One
- Salinomycin Induces Autophagy in Colon and Breast Cancer Cells with Concomitant Generation of Reactive Oxygen Species
- (2012) Berlinda Verdoodt et al. PLoS One
- Cyclosporin A inhibits the replication of diverse coronaviruses
- (2011) A. H. de Wilde et al. JOURNAL OF GENERAL VIROLOGY
- Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
- (2011) I. Glowacka et al. JOURNAL OF VIROLOGY
- Chicken cyclophilin A is an inhibitory factor to influenza virus replication
- (2011) Chongfeng Xu et al. Virology Journal
- R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
- (2010) S. J. Holland et al. CANCER RESEARCH
- Hepatitis B Virus (HBV) Surface Antigen Interacts with and Promotes Cyclophilin A Secretion: Possible Link to Pathogenesis of HBV Infection
- (2010) X. Tian et al. JOURNAL OF VIROLOGY
- An emerging role for p21-activated kinases (Paks) in viral infections
- (2010) Celine Van den Broeke et al. TRENDS IN CELL BIOLOGY
- The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells
- (2010) Thorsten Eierhoff et al. PLoS Pathogens
- Histamine H1-receptor antagonists with immunomodulating activities: potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases
- (2009) T. Okamoto et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors
- (2009) Yu Yu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
- (2009) S. Belouzard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential effects of triptolide and tetrandrine on activation of COX-2, NF-κB, and AP-1 and virus production in dengue virus-infected human lung cells
- (2008) Jun-Ting Liou et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro
- (2008) F. Yang et al. JOURNAL OF VIROLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started