Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity

(2020) Julia Niessl et al.   NATURE MEDICINE

The Challenges of Vaccine Development against a New Virus during a Pandemic

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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

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A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

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Human neutralizing antibodies elicited by SARS-CoV-2 infection

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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

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A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

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Severe COVID-19 is marked by a dysregulated myeloid cell compartment

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Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

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A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

(2020) Dorottya Laczkó et al.   IMMUNITY

Monoclonal Antibodies for Prevention and Treatment of COVID-19

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A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

(2020) Wafaa B. Alsoussi et al.   JOURNAL OF IMMUNOLOGY

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

(2020) Seth J. Zost et al.   NATURE MEDICINE

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

(2020) Johanna Hansen et al.   SCIENCE

A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model

(2020) Jakob Kreye et al.   CELL

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

(2020) Sarah R. Leist et al.   CELL

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

(2020) Ildefonso Sánchez-Cerrillo et al.   JOURNAL OF CLINICAL INVESTIGATION

COVID-19 Vaccines: Should We Fear ADE?

(2020) Scott B Halstead et al.   JOURNAL OF INFECTIOUS DISEASES

Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction

(2020) Luigi Adamo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection

(2020) Stylianos Bournazos et al.   NATURE

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

(2020) Lisa H. Tostanoski et al.   NATURE MEDICINE

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

(2020) Alina Baum et al.   SCIENCE

Growth, detection, quantification, and inactivation of SARS-CoV-2

(2020) James Brett Case et al.   VIROLOGY

A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

(2020) Tal Noy-Porat et al.   Nature Communications

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

(2020) Wen Shi Lee et al.   Nature Microbiology

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

(2020) Joseph W. Golden et al.   JCI Insight

Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

(2020) Tomer Zohar et al.   CELL

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

(2020) Alexandra Schäfer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

(2020) Peter Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life

(2019) Kevin O. Saunders   Frontiers in Immunology

Immunological Lessons from Respiratory Syncytial Virus Vaccine Development

(2019) Tracy J. Ruckwardt et al.   IMMUNITY

Differential requirements for FcγR engagement by protective antibodies against Ebola virus

(2019) Stylianos Bournazos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

(2019) Jeanette L. Gehrig et al.   SCIENCE

Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine

(2018) Fan Luo et al.   VIROLOGICA SINICA

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

(2017) Megan Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

(2017) Wenqian He et al.   Nature Communications

Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection

(2017) Qiang Liu et al.   Scientific Reports

A potent human neutralizing antibody Fc-dependently reduces established HBV infections

(2017) Dan Li et al.   eLife

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

(2016) David J. DiLillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

Enhancing dengue virus maturation using a stable furin over-expressing cell line

(2016) Swati Mukherjee et al.   VIROLOGY

Fc receptors in antibody-dependent enhancement of viral infections

(2015) Adam Taylor et al.   IMMUNOLOGICAL REVIEWS

Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells

(2015) Jake Chng et al.   mAbs

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses

(2015) Ruijie Liu et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

(2015) G. Fibriansah et al.   SCIENCE

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Crucial Role of Aspartic Acid at Position 265 in the CH2 Domain for Murine IgG2a and IgG2b Fc-Associated Effector Functions

(2014) L. Baudino et al.   JOURNAL OF IMMUNOLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

(2013) Brian J. Laidlaw et al.   PLoS Pathogens

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Autonomous phagosomal degradation and antigen presentation in dendritic cells

(2012) E. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse model recapitulating human Fc  receptor structural and functional diversity

(2012) P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poorly Neutralizing Cross-Reactive Antibodies against the Fusion Loop of West Nile Virus Envelope Protein Protect In Vivo via Fc  Receptor and Complement-Dependent Effector Mechanisms

(2011) M. R. Vogt et al.   JOURNAL OF VIROLOGY

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS