期刊
CURRENT OPINION IN VIROLOGY
卷 14, 期 -, 页码 56-61出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2015.08.004
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资金
- German Ministry for Education and Research (BMBF) [01KI1005F]
- Novartis AG, Switzerland
- German Center for Infection Research (DZIF)
Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of several viruses. Here, we summarize present knowledge on the role of cyclophilin A during coronavirus replication. We present data on the effect of cyclophilin A single nucleotide polymorphism mutants on the replication of human CoV-229E demonstrating the requirement of proper cyclophilin A function for virus propagation. Results define cellular cyclophilin A as a host target for inhibition of coronaviruses ranging from relatively mild common cold to highly pathogenic SARS-CoV and MERS-CoV viruses with the perspective of disclosing non-immunosuppressive cyclosporin A analogs to broadly inactivate the coronavirus family.
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