TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability

TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway

(2020) Yanfeng Liu et al.   Nature Communications

Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cells

(2020) Anup Kumar Singh et al.   Epigenetics

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

(2020) Wei Cao et al.   Nature Communications

The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

(2020) Anne Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

(2019) Evelyne Lima-Fernandes et al.   Nature Communications

BRCA1 and EZH2 cooperate in regulation of prostate cancer stem cell phenotype

(2019) Ielizaveta Gorodetska et al.   INTERNATIONAL JOURNAL OF CANCER

Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies

(2019) Audrey Vincent et al.   World Journal of Stem Cells

Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation

(2018) Yoon Min et al.   Autophagy

TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer

(2018) Ken-ichi Takayama et al.   ONCOGENE

O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2

(2018) Pei-Wen Lo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

(2018) Loïc Lionnard et al.   CELL DEATH AND DIFFERENTIATION

Emerging roles of Myc in stem cell biology and novel tumor therapies

(2018) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense

(2018) Jacint G. Sanchez et al.   JOURNAL OF MOLECULAR BIOLOGY

TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels

(2017) Ankush Borlepawar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2

(2017) Peilong Li et al.   MOLECULAR CANCER THERAPEUTICS

Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation

(2017) Silvia Consalvi et al.   Nature Communications

An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis

(2017) Logan A. Walsh et al.   Cell Reports

SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer

(2016) W Lu et al.   ONCOGENE

Overexpression of TRIM25 in Lung Cancer Regulates Tumor Cell Progression

(2016) Ying Qin et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation

(2015) Na-Rae Lee et al.   MOLECULES AND CELLS

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2

(2015) Maupali Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination

(2014) Zhenzhen Zhan et al.   Autophagy

A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells

(2014) Joan Fernando et al.   INTERNATIONAL JOURNAL OF CANCER

Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation

(2014) A A Sahasrabuddhe et al.   ONCOGENE

O-GlcNAcylation regulates EZH2 protein stability and function

(2014) C.-S. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 expands breast stem cells through activation of NOTCH1 signaling

(2014) M. E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of Ezh2 methyltransferase by FOXP3: New insight of FOXP3 into chromatin remodeling?

(2013) Zhu Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

(2013) Yung-Luen Yu et al.   EMBO Molecular Medicine

PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation

(2013) Hae-Yun Jung et al.   MOLECULAR CELL

Self-renewal as a therapeutic target in human colorectal cancer

(2013) Antonija Kreso et al.   NATURE MEDICINE

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

(2008) M. U. Gack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA