SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer

The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

(2015) Shi Jiao et al.   NATURE IMMUNOLOGY

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

(2015) Wenfu Lu et al.   Oncotarget

The association between Histone 3 Lysine 27 Trimethylation (H3K27me3) and prostate cancer: relationship with clinicopathological parameters

(2015) Marjolaine Ngollo et al.   BMC CANCER

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

(2015) Joao Vasco Ferreira et al.   Scientific Reports

Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

(2014) Naoto Sugeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostate cancer epigenetic biomarkers: next-generation technologies

(2014) F Valdés-Mora et al.   ONCOGENE

Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation

(2014) A A Sahasrabuddhe et al.   ONCOGENE

O-GlcNAcylation regulates EZH2 protein stability and function

(2014) C.-S. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Role of EZH2 in Cancer

(2014) Hirohito Yamaguchi et al.   Cancer Research and Treatment

Downregulation of Ezh2 methyltransferase by FOXP3: New insight of FOXP3 into chromatin remodeling?

(2013) Zhu Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity

(2013) Jianfei Qi et al.   CANCER CELL

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

(2013) Chia-Hsin Chan et al.   CELL

Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

(2013) Yung-Luen Yu et al.   EMBO Molecular Medicine

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

(2013) Li Zhang et al.   JOURNAL OF LIPID RESEARCH

PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation

(2013) Hae-Yun Jung et al.   MOLECULAR CELL

ARF Represses Androgen Receptor Transactivation in Prostate Cancer

(2013) Wenfu Lu et al.   MOLECULAR ENDOCRINOLOGY

Lysine 63-linked polyubiquitination is required for EGF receptor degradation

(2013) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer

(2013) Bo Li et al.   PROSTATE

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling Activities

(2012) Luis J. Cocka et al.   PLoS Pathogens

PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins

(2011) Muhammad Zoabi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer

(2011) Jörg Ellinger et al.   CANCER INVESTIGATION

Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis

(2011) T-Y Lin et al.   ONCOGENE

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction

(2010) Daming Gao et al.   MOLECULAR CELL

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

(2010) Chia-Hsin Chan et al.   NATURE CELL BIOLOGY

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development

(2010) W-L Yang et al.   ONCOGENE

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

Genome-Wide Profiling of Histone H3 Lysine 4 and Lysine 27 Trimethylation Reveals an Epigenetic Signature in Prostate Carcinogenesis

(2009) Xi-Song Ke et al.   PLoS One

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE