Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation

EZH2 mutations are frequent and represent an early event in follicular lymphoma

(2013) C. Bodor et al.   BLOOD

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

(2013) Yung-Luen Yu et al.   EMBO Molecular Medicine

DNA Damage Regulates UHRF1 Stability via the SCFβ-TrCPE3 Ligase

(2013) Hao Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia

(2013) T. Velusamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Molecular architecture of human polycomb repressive complex 2

(2012) Claudio Ciferri et al.   eLife

PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins

(2011) Muhammad Zoabi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

βTrCP regulates BMI1 protein turnover via ubiquitination and degradation

(2011) Anagh A. Sahasrabuddhe et al.   CELL CYCLE

SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

(2011) M.-K. M. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Roles of the Polycomb group proteins in stem cells and cancer

(2011) H Richly et al.   Cell Death & Disease

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

(2010) I. Velichutina et al.   BLOOD

Polycomb proteins in hematologic malignancies

(2010) D. Martin-Perez et al.   BLOOD

Polycomb Group Proteins Set the Stage for Early Lineage Commitment

(2010) Lauren E. Surface et al.   Cell Stem Cell

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

(2010) Martin Sauvageau et al.   Cell Stem Cell

Epigenetic factors in cancer development: Polycomb group proteins

(2010) Andrea Piunti et al.   Future Oncology

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

(2010) S. Kaneko et al.   GENES & DEVELOPMENT

Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain

(2010) Ajay K Yadav et al.   Molecular Cancer

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Polycomb group protein-mediated repression of transcription

(2010) Lluís Morey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells

(2009) Manjari Dimri et al.   CARCINOGENESIS

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE