标题
The Life Cycle of the Mu-Opioid Receptor
作者
关键词
G protein-coupled receptor, OPRM1, mu-opioid signalling, pain, reward, addiction
出版物
TRENDS IN BIOCHEMICAL SCIENCES
Volume 46, Issue 4, Pages 315-328
出版商
Elsevier BV
发表日期
2020-10-28
DOI
10.1016/j.tibs.2020.10.002
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling
- (2020) Andrea Kliewer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Morphine modulates the expression of mu‐opioid receptor exon 5‐associated full‐length C‐terminal splice variants by upregulating miR‐378a‐3p
- (2020) Zhigang Lu et al. FASEB JOURNAL
- OPRM1 and COMT polymorphisms: implications on postoperative acute, chronic and experimental pain after cardiac surgery
- (2020) Maja Matic et al. PHARMACOGENOMICS
- An analysis of the effect of mu-opioid receptor gene (OPRM1) promoter region DNA methylation on the response of naltrexone treatment of alcohol dependence
- (2020) Yufei Lin et al. PHARMACOGENOMICS JOURNAL
- Opioid pharmacology under the microscope
- (2020) Damien Jullié et al. MOLECULAR PHARMACOLOGY
- Impaired alcohol-induced dopamine release in the nucleus accumbens in an inflammatory pain model
- (2020) Yolanda Campos-Jurado et al. PAIN
- Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
- (2020) Alexander Gillis et al. Science Signaling
- Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors
- (2020) Jan Möller et al. Nature Chemical Biology
- Post-translational Modifications of Opioid Receptors
- (2020) Mariana Lemos Duarte et al. TRENDS IN NEUROSCIENCES
- Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
- (2019) A. Kliewer et al. Nature Communications
- APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy
- (2019) Eugene R Viscusi et al. Journal of Pain Research
- Polymorphism A118G of opioid receptor mu 1 (OPRM1) is associated with emergence of suicidal ideation at antidepressant onset in a large naturalistic cohort of depressed outpatients
- (2019) B. Nobile et al. Scientific Reports
- A biased view of µ opioid receptors?
- (2019) Alexandra E Conibear et al. MOLECULAR PHARMACOLOGY
- Homologous regulation of mu opioid receptor recycling by Gβγ, Protein Kinase C, and receptor phosphorylation
- (2019) Jennifer M Kunselman et al. MOLECULAR PHARMACOLOGY
- Separation of Acute Desensitization and Long-Term Tolerance of µ-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation
- (2019) Seksiri Arttamangkul et al. MOLECULAR PHARMACOLOGY
- Associations among the opioid receptor gene (OPRM1) A118G polymorphism, psychiatric symptoms, and quantitative EEG in Korean males with gambling disorder: A pilot study
- (2019) Kyoung Min Kim et al. Journal of Behavioral Addictions
- Epidural Analgesia With Sufentanil in Relation to OPRM1 and ABCB1 Polymorphisms
- (2019) O. BARTOŠOVÁ et al. PHYSIOLOGICAL RESEARCH
- Activation of MORs in the VTA induces changes on cFos expression in different projecting regions: Effect of inflammatory pain
- (2019) Yolanda Campos-Jurado et al. NEUROCHEMISTRY INTERNATIONAL
- A Discrete Presynaptic Vesicle Cycle for Neuromodulator Receptors
- (2019) Damien Jullié et al. NEURON
- Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia
- (2018) Zhigang Lu et al. ANESTHESIA AND ANALGESIA
- Opioid and Notch signaling pathways are reciprocally regulated through miR- 29a and miR-212 expression
- (2018) Adrian Garcia-Concejo et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Opioid receptors: drivers to addiction?
- (2018) Emmanuel Darcq et al. NATURE REVIEWS NEUROSCIENCE
- Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits
- (2018) Dong Wang et al. NEURON
- Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization
- (2018) Elke Miess et al. Science Signaling
- Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization
- (2018) Elke Miess et al. Science Signaling
- Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms
- (2018) Marjo Piltonen et al. MOLECULAR NEUROBIOLOGY
- Structure of the µ-opioid receptor–Gi protein complex
- (2018) Antoine Koehl et al. NATURE
- The role of OPRM1 polymorphism in the etiology of alcoholism
- (2018) Agnieszka Samochowiec et al. Advances in Clinical and Experimental Medicine
- Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
- (2018) Muzeyyen Ugur et al. Frontiers in Pharmacology
- Identification of Circulating miRNAs Differentially Regulated by Opioid Treatment
- (2017) Kaoru Toyama et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A “tail” of opioid receptor variants
- (2017) Stephanie Puig et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents
- (2017) Ahmad A Altarifi et al. JOURNAL OF PSYCHOPHARMACOLOGY
- GPCRdb in 2018: adding GPCR structure models and ligands
- (2017) Gáspár Pándy-Szekeres et al. NUCLEIC ACIDS RESEARCH
- The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment
- (2017) Orna Levran et al. PHARMACOGENOMICS
- Association of opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with nicotine dependence
- (2017) Xiangyi Kong et al. Oncotarget
- Elevated levels of DNA methylation at the OPRM1 promoter region in men with opioid use disorder
- (2017) Ghasem Ebrahimi et al. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
- Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide
- (2017) Laurie-Anne Roeckel et al. Scientific Reports
- G Protein–Coupled Receptor Heteromers
- (2016) Ivone Gomes et al. Annual Review of Pharmacology and Toxicology
- Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
- (2016) András Váradi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-based discovery of opioid analgesics with reduced side effects
- (2016) Aashish Manglik et al. NATURE
- Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling
- (2016) Michelle L. Halls et al. Science Signaling
- Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants
- (2016) Steven G. Grinnell et al. SYNAPSE
- Prefrontal Cortical Opioids and Dysregulated Motivation: A Network Hypothesis
- (2016) Brian A. Baldo TRENDS IN NEUROSCIENCES
- Pharmacoepigenetics of the role of DNA methylation in μ-opioid receptor expression in different human brain regions
- (2016) Claudia Knothe et al. Epigenomics
- Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling
- (2016) Michelle L. Halls et al. Science Signaling
- Simian Immunodeficiency Virus Impacts MicroRNA-16 Mediated Post-Transcriptional Regulation of mu Opioid Receptor in CEM ×174 Cells
- (2015) Wenting Hou et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area Opioid Receptors
- (2015) L. Hipolito et al. JOURNAL OF NEUROSCIENCE
- Structural insights into µ-opioid receptor activation
- (2015) Weijiao Huang et al. NATURE
- Propagation of conformational changes during μ-opioid receptor activation
- (2015) Rémy Sounier et al. NATURE
- μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids
- (2015) Marino Convertino et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)
- (2014) Alisa Knapman et al. BRITISH JOURNAL OF PHARMACOLOGY
- Epigenetic Variation in the Mu-Opioid Receptor Gene in Infants with Neonatal Abstinence Syndrome
- (2014) Elisha M. Wachman et al. JOURNAL OF PEDIATRICS
- Advances in the neurobiological bases for food ‘liking’ versus ‘wanting’
- (2014) D.C. Castro et al. PHYSIOLOGY & BEHAVIOR
- Influence of Mu-Opioid Receptor Variant on Morphine Use and Self-Rated Pain Following Abdominal Hysterectomy
- (2013) Alex T. Sia et al. JOURNAL OF PAIN
- Neurocircuitry of drug reward
- (2013) Satoshi Ikemoto et al. NEUROPHARMACOLOGY
- Neural mechanisms of pain and alcohol dependence
- (2013) A. Vania Apkarian et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P
- (2013) Jin Xu et al. SYNAPSE
- Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?
- (2013) Elisa Mura et al. Journal of Pain Research
- Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling
- (2012) Hui Zheng et al. BMC CELL BIOLOGY
- Regulation of μ-opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation
- (2012) J. Ni et al. EUROPEAN JOURNAL OF PAIN
- MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment
- (2012) Qifang Wu et al. FASEB JOURNAL
- Genetic–epigenetic interaction modulates µ-opioid receptor regulation
- (2012) Bruno G. Oertel et al. HUMAN MOLECULAR GENETICS
- Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence
- (2012) Huiping Zhang et al. JOURNAL OF HUMAN GENETICS
- Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
- (2012) Aashish Manglik et al. NATURE
- Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system
- (2012) Yukie Kawahara et al. NEUROPHARMACOLOGY
- Transcriptional and Epigenetic Regulation of Opioid Receptor Genes: Present and Future
- (2011) Li-Na Wei et al. Annual Review of Pharmacology and Toxicology
- A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability
- (2011) Peng Huang et al. BIOCHEMICAL JOURNAL
- Nucleus Accumbens -Opioid Receptors Mediate Social Reward
- (2011) V. Trezza et al. JOURNAL OF NEUROSCIENCE
- Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: Involvement of μ-opioid receptors
- (2011) Lucía Hipólito et al. NEUROCHEMISTRY INTERNATIONAL
- Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins
- (2010) Judit Remenyi et al. BIOCHEMICAL JOURNAL
- Regulation of Opioid Tolerance by let-7 Family MicroRNA Targeting the Opioid Receptor
- (2010) Y. He et al. JOURNAL OF NEUROSCIENCE
- Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors
- (2009) Adam J. Kuszak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reward Processing by the Opioid System in the Brain
- (2009) Julie Le Merrer et al. PHYSIOLOGICAL REVIEWS
- Increased OPRM1 DNA Methylation in Lymphocytes of Methadone-Maintained Former Heroin Addicts
- (2008) David A Nielsen et al. NEUROPSYCHOPHARMACOLOGY
- Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor
- (2007) Peng Huang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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