Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling

(2016) D. Zindel et al.   BIOCHEMICAL JOURNAL

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

(2016) Michelle L. Halls et al.   Science Signaling

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

(2016) Michelle L. Halls et al.   Science Signaling

Increases in Drug and Opioid-Involved Overdose Deaths — United States, 2010–2015

(2016) Rose A. Rudd et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Loss of Morphine Reward and Dependence in Mice Lacking G Protein–Coupled Receptor Kinase 5

(2014) Laura Glück et al.   BIOLOGICAL PSYCHIATRY

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor

(2014) A E Cooke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Different mechanisms of homologous and heterologous μ-opioid receptor phosphorylation

(2014) Anika Mann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C

(2013) Susann Illing et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Receptor-attached Phosphates in Binding of Visual and Non-visual Arrestins to G Protein-coupled Receptors

(2012) Luis E. Gimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

(2012) Tien-Hung Lan et al.   TRAFFIC

Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies

(2011) Christian Doll et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rapid Dephosphorylation of G Protein-coupled Receptors by Protein Phosphatase 1β Is Required for Termination of β-Arrestin-dependent Signaling

(2011) Florian Pöll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analgesic Tolerance to High-Efficacy Agonists But Not to Morphine Is Diminished in Phosphorylation-Deficient S375A  -Opioid Receptor Knock-In Mice

(2011) G. Grecksch et al.   JOURNAL OF NEUROSCIENCE

Cellular Morphine Tolerance Produced by  Arrestin-2-Dependent Impairment of  -Opioid Receptor Resensitization

(2011) V. C. Dang et al.   JOURNAL OF NEUROSCIENCE

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

(2011) D. M. Thal et al.   MOLECULAR PHARMACOLOGY

Quantitative Encoding of the Effect of a Partial Agonist on Individual Opioid Receptors by Multisite Phosphorylation and Threshold Detection

(2011) E. K. Lau et al.   Science Signaling

Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase

(2010) Adi Raveh et al.   CELL

Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions

(2010) Paola Molinari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

(2010) J. McPherson et al.   MOLECULAR PHARMACOLOGY

Bright cyan fluorescent protein variants identified by fluorescence lifetime screening

(2010) Joachim Goedhart et al.   NATURE METHODS

UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues

(2010) Amelie Lupp et al.   REGULATORY PEPTIDES

Differential Effects of Octreotide and Pasireotide on Somatostatin Receptor Internalization and Traffickingin Vitro

(2008) Sarah Lesche et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM