Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

(2018) Elke Miess et al.   Science Signaling

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

(2018) Elke Miess et al.   Science Signaling

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(2016) Zoran Rankovic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

(2016) Polymnia Georgiou et al.   NEUROPHARMACOLOGY

Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms

(2015) Jamie Rose Kuhar et al.   CELLULAR SIGNALLING

μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive

(2015) Erica S. Levitt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss of Morphine Reward and Dependence in Mice Lacking G Protein–Coupled Receptor Kinase 5

(2014) Laura Glück et al.   BIOLOGICAL PSYCHIATRY

Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C

(2013) Susann Illing et al.   BRITISH JOURNAL OF PHARMACOLOGY

A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome

(2013) Erica S. Levitt et al.   JOURNAL OF APPLIED PHYSIOLOGY

Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells

(2012) Christian Doll et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor

(2012) Ying-Ju Chen et al.   JOURNAL OF NEUROCHEMISTRY

Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs

(2012) Ivana Prkic et al.   JOURNAL OF NEUROPHYSIOLOGY

Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies

(2011) Christian Doll et al.   BRITISH JOURNAL OF PHARMACOLOGY

Analgesic Tolerance to High-Efficacy Agonists But Not to Morphine Is Diminished in Phosphorylation-Deficient S375A  -Opioid Receptor Knock-In Mice

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Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Agonist-dependent μ-opioid receptor signaling can lead to heterologous desensitization

(2010) Ji Chu et al.   CELLULAR SIGNALLING

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics

(2010) Kirsten M. Raehal et al.   NEUROPHARMACOLOGY

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling

(2010) E. J. Melief et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6

(2009) Kirsten M. Raehal et al.   DRUG AND ALCOHOL DEPENDENCE

Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

(2009) C. P. Bailey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE