4.1 Article

Synthesis of deuterium-labeled pregabalin

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WILEY-BLACKWELL
DOI: 10.1002/jlcr.1936

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deuterium; labeled; synthesis; pregabalin

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  1. Nanjing University of Technology and Nanjing New & High Technology Industry Development Zone

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This paper describes the synthesis of deuterium-labeled pregabalin. The stable isotopic-labeled compound was obtained in nine steps starting from the commercially available 4-[2H11]methylvaleric acid as the stable-labeled reagent. It is used as an internal standard for analysis and metabolic studies.

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