Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers

Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids

(2021) Petra Geiser et al.   mBio

Germ‐free and microbiota‐associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes

(2020) Annika Hausmann et al.   CELLULAR MICROBIOLOGY

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

(2020) Annika Hausmann et al.   Mucosal Immunology

Salmonella enterica infection of murine and human enteroid-derived monolayers elicits differential activation of epithelial-intrinsic inflammasomes

(2020) Mayumi K. Holly et al.   INFECTION AND IMMUNITY

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes

(2020) Shauna M. Crowley et al.   PLoS Pathogens

Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium

(2020) Stefan A. Fattinger et al.   PLoS Pathogens

Rotavirus induces intercellular calcium waves through ADP signaling

(2020) Alexandra L. Chang-Graham et al.   SCIENCE

Epithelial inflammasomes in the defense against Salmonella gut infection

(2020) Stefan A Fattinger et al.   CURRENT OPINION IN MICROBIOLOGY

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

(2019) Julia Y. Co et al.   Cell Reports

Asymmetric paralog evolution between the “cryptic” gene Bmp16 and its well-studied sister genes Bmp2 and Bmp4

(2019) Nathalie Feiner et al.   Scientific Reports

Apical constriction is necessary for crypt formation in small intestinal organoids

(2019) Leonie Hartl et al.   DEVELOPMENTAL BIOLOGY

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

(2019) Markus Furter et al.   Cell Reports

Canonical and noncanonical inflammasomes in intestinal epithelial cells

(2019) Nathaniel Winsor et al.   CELLULAR MICROBIOLOGY

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo

(2018) Kaiyi Zhang et al.   PLoS Pathogens

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

(2018) April E. Price et al.   IMMUNITY

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

(2018) Constanza Alcaino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion

(2018) Ehsan Sadeghipour et al.   eLife

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

Swiss Army Pathogen: The Salmonella Entry Toolkit

(2017) Peter J. Hume et al.   Frontiers in Cellular and Infection Microbiology

Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform

(2017) Kenji Kozuka et al.   Stem Cell Reports

Physiology of Intestinal Absorption and Secretion

(2016) Pawel R. Kiela et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

A Perspective on the Role of Myosins as Mechanosensors

(2016) Michael J. Greenberg et al.   BIOPHYSICAL JOURNAL

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo

(2016) Isabella Rauch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

(2016) Hana M. Russo et al.   JOURNAL OF IMMUNOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes of the intestinal epithelium

(2015) Mikael E. Sellin et al.   TRENDS IN IMMUNOLOGY

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

(2015) Shuiqing Hu et al.   Cell Reports

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

(2014) A. C. Martin et al.   DEVELOPMENT

Actin polymerization as a key innate immune effector mechanism to controlSalmonellainfection

(2014) Si Ming Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis

(2013) C Moon et al.   Mucosal Immunology

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

(2012) Anwari Akhter et al.   IMMUNITY

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway

(2011) Yapeng Gu et al.   JOURNAL OF CELL BIOLOGY

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

Tissue elongation requires oscillating contractions of a basal actomyosin network

(2010) Li He et al.   NATURE CELL BIOLOGY

Dissemination of invasiveSalmonellavia bacterial-induced extrusion of mucosal epithelia

(2010) Leigh A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potentiation of Epithelial Innate Host Responses by Intercellular Communication

(2010) Tamas Dolowschiak et al.   PLoS Pathogens

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Pyrin and ASC Co-Localize to Cellular Sites that Are Rich in Polymerizing Actin

(2008) Andrea L. Waite et al.   EXPERIMENTAL BIOLOGY AND MEDICINE