Epithelial inflammasomes in the defense against Salmonella gut infection

Germ‐free and microbiota‐associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes

(2020) Annika Hausmann et al.   CELLULAR MICROBIOLOGY

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

(2020) Annika Hausmann et al.   Mucosal Immunology

Import of Aspartate and Malate by DcuABC Drives H2/Fumarate Respiration to Promote Initial Salmonella Gut-Lumen Colonization in Mice

(2020) Bidong D. Nguyen et al.   Cell Host & Microbe

Salmonella enterica infection of murine and human enteroid-derived monolayers elicits differential activation of epithelial-intrinsic inflammasomes

(2020) Mayumi K. Holly et al.   INFECTION AND IMMUNITY

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes

(2020) Shauna M. Crowley et al.   PLoS Pathogens

Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18

(2020) Namrata Iyer et al.   PLoS Pathogens

Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium

(2020) Stefan A. Fattinger et al.   PLoS Pathogens

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

(2020) Balázs Koscsó et al.   Science Immunology

How Food Affects Colonization Resistance Against Enteropathogenic Bacteria

(2020) Markus Kreuzer et al.   Annual Review of Microbiology

The NAIP/NLRC4 inflammasome in infection and pathology

(2020) Renate Bauer et al.   MOLECULAR ASPECTS OF MEDICINE

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

(2020) José Carlos Santos et al.   Nature Communications

Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection

(2019) Eric M. Velazquez et al.   Nature Microbiology

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

(2019) Markus Furter et al.   Cell Reports

Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models

(2019) Susan J. Robertson et al.   Cell Reports

Canonical and noncanonical inflammasomes in intestinal epithelial cells

(2019) Nathaniel Winsor et al.   CELLULAR MICROBIOLOGY

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

(2019) Augusto V. Gonçalves et al.   PLoS Pathogens

Ripk3 licenced protection against microbial infection in the absence of Caspase1-11 inflammasome

(2019) Bojan Shutinoski et al.   MICROBES AND INFECTION

Host inflammasome defense mechanisms and bacterial pathogen evasion strategies

(2019) Susan M Brewer et al.   CURRENT OPINION IN IMMUNOLOGY

Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid

(2019) Mamunur Rashid Mahib et al.   MICROBIOLOGY AND IMMUNOLOGY

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice

(2019) Sandra Y. Wotzka et al.   Nature Microbiology

IRF8 Regulates Transcription of Naip s for NLRC4 Inflammasome Activation

(2018) Rajendra Karki et al.   CELL

Defining the Impact of Host Genotypes on Microbiota Composition Requires Meticulous Control of Experimental Variables

(2018) Andy Wullaert et al.   IMMUNITY

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo

(2018) Kaiyi Zhang et al.   PLoS Pathogens

Gastrointestinal Infection Increases Odds of Inflammatory Bowel Disease in a Nationwide Case–Control Study

(2018) Jordan E. Axelrad et al.   Clinical Gastroenterology and Hepatology

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition

(2017) Michail Mamantopoulos et al.   IMMUNITY

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

(2016) Harding H. Luan et al.   Cell Metabolism

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo

(2016) Isabella Rauch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice

(2016) Yue Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

(2016) Teresa L. M. Thurston et al.   Nature Communications

An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection

(2016) Anna A. Müller et al.   PLoS Pathogens

Epithelial NAIPs protect against colonic tumorigenesis

(2015) Ramanjaneyulu Allam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Salmonellae interactions with host processes

(2015) Doris L. LaRock et al.   NATURE REVIEWS MICROBIOLOGY

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Citrobacter rodentium: infection, inflammation and the microbiota

(2014) James W. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis

(2014) Lisa Maier et al.   PLoS Pathogens

Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella

(2014) Kaiyi Zhang et al.   PLoS Pathogens

Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein

(2013) M. Rayamajhi et al.   JOURNAL OF IMMUNOLOGY

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

(2013) S Nordlander et al.   Mucosal Immunology

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1

(2012) Niall S. Kenneth et al.   BIOCHEMICAL JOURNAL

Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

(2012) F A Carvalho et al.   Mucosal Immunology

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Mimicking GEFs: a common theme for bacterial pathogens

(2011) Robert C. Orchard et al.   CELLULAR MICROBIOLOGY

The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune response

(2011) Patrick Kaiser et al.   IMMUNOLOGICAL REVIEWS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection

(2011) Pascal Songhet et al.   PLoS One

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

(2010) R. K. S. Malireddi et al.   JOURNAL OF IMMUNOLOGY

Gut inflammation provides a respiratory electron acceptor for Salmonella

(2010) Sebastian E. Winter et al.   NATURE

Dissemination of invasiveSalmonellavia bacterial-induced extrusion of mucosal epithelia

(2010) Leigh A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria

(2010) Bärbel Stecher et al.   PLoS Pathogens

The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation

(2009) Andreas J. Müller et al.   Cell Host & Microbe

The Citrobacter rodentium Genome Sequence Reveals Convergent Evolution with Human Pathogenic Escherichia coli

(2009) N. K. Petty et al.   JOURNAL OF BACTERIOLOGY

Distribution of espM and espT among enteropathogenic and enterohaemorrhagic Escherichia coli

(2009) A. Arbeloa et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Molecular mechanisms of Escherichia coli pathogenicity

(2009) Matthew A. Croxen et al.   NATURE REVIEWS MICROBIOLOGY

Motility allows S. Typhimurium to benefit from the mucosal defence

(2008) Bärbel Stecher et al.   CELLULAR MICROBIOLOGY

T Cells Help To Amplify Inflammatory Responses Induced by Salmonella enterica Serotype Typhimurium in the Intestinal Mucosa

(2008) I. Godinez et al.   INFECTION AND IMMUNITY

Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent stepin ΔinvG S. Typhimurium colitis

(2008) Siegfried Hapfelmeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

Self-destructive cooperation mediated by phenotypic noise

(2008) Martin Ackermann et al.   NATURE