期刊
TRENDS IN IMMUNOLOGY
卷 36, 期 8, 页码 442-450出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.06.002
关键词
innate immunity; intestinal epithelial cell (IEC); caspase-1; NLRP3; extrusion; mucus
类别
资金
- Swiss National Science Foundation [310030_153074/1]
- Swedish Research Council fellowship [2012-262]
- RIKEN Program for Junior Scientists
- Wellcome Trust [102972]
- Swiss National Science Foundation (SNF) [310030_153074] Funding Source: Swiss National Science Foundation (SNF)
While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosa! immunity. Recent studies have revealed functional roles of inflammasomes particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosa! immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host microbiota mutualism, and communicate with immune cells of the underlying lamina propria.
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