期刊
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
卷 30, 期 2, 页码 145-159出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2016.02.007
关键词
Epithelial transport; Sodium; Chloride; Short chain fatty acids; Sulfate; Oxalate; Carbohydrates; Amino acids; Lipids; vitamins; Minerals; Micronutrients
资金
- NIDDK NIH HHS [R37 DK033209, R01 DK041274] Funding Source: Medline
Virtually all nutrients from the diet are absorbed into blood across the highly polarized epithelial cell layer forming the small and large intestinal mucosa. Anatomical, histological, and functional specializations along the gastrointestinal tract are responsible for the effective and regulated nutrient transport via both passive and active mechanisms. In this chapter, we summarize the current state of knowledge regarding the mechanism of intestinal absorption of key nutrients such as sodium, anions (chloride, sulfate, oxalate), carbohydrates, amino acids and peptides, lipids, lipid and water-soluble vitamins, as well as the major minerals and micronutrients. This outline, including the molecular identity, specificity, and coordinated activities of key transport proteins and genes involved, serves as the background for the following chapters focused on the pathophysiology of acquired and congenital intestinal malabsorption, as well as clinical tools to test and treat malabsorptive symptoms. (C) 2016 Elsevier Ltd. All rights reserved.
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