Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution

(2014) K. Kasuga et al.   JOURNAL OF IMMUNOLOGY

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

(2013) F. K. Swirski et al.   SCIENCE

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

Induction of Anti-Anti-Idiotype Antibodies Against Sulfated Glycosaminoglycans Reduces Atherosclerosis in Apolipoprotein E–Deficient Mice

(2012) Víctor Brito et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets

(2012) Giulio R. Romeo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Inflammation and Coronary Artery Disease: Insights From Genetic Studies

(2012) Ruth McPherson et al.   CANADIAN JOURNAL OF CARDIOLOGY

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Conditional Targeting of Tumor Necrosis Factor Receptor–Associated Factor 6 Reveals Opposing Functions of Toll-Like Receptor Signaling in Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis

(2012) Apostolos Polykratis et al.   CIRCULATION

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

(2012) J. Claria et al.   JOURNAL OF IMMUNOLOGY

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

(2012) Joshua D. Stender et al.   MOLECULAR CELL

Bad matters made worse

(2012) Ira Tabas   NATURE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice

(2012) W. Cui et al.   NEUROSCIENCE

Kinase Inhibition — A New Approach to the Treatment of Rheumatoid Arthritis

(2012) David A. Fox   NEW ENGLAND JOURNAL OF MEDICINE

T Cell Signaling Targets for Enhancing Regulatory or Effector Function

(2012) F. Pan et al.   Science Signaling

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis

(2012) Jasvinder A. Singh et al.   ARTHRITIS CARE & RESEARCH

Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

(2012) Sang-il Lee et al.   ARTHRITIS RESEARCH & THERAPY

Regression of Inflammation in Atherosclerosis by the LXR Agonist R211945

(2012) Esad Vucic et al.   JACC-Cardiovascular Imaging

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

(2011) Matthew R. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

(2011) Mark E. Lobatto et al.   NATURE REVIEWS DRUG DISCOVERY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

(2011) Laure Escoubet-Lozach et al.   PLoS Genetics

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Liver X Receptor Signaling Pathways and Atherosclerosis

(2010) Anna C. Calkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation as “common soil” of the multifactorial diseases

(2010) Rossana Scrivo et al.   AUTOIMMUNITY REVIEWS

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Dendritic Cells, Indoleamine 2,3 Dioxygenase and Acquired Immune Privilege

(2010) Lei Huang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Atopic dermatitis in older patients: particular points

(2010) A Katsarou et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Cryopyrin-associated periodic syndromes: background and therapeutics

(2010) Tetsuo Kubota et al.   Modern Rheumatology

Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis

(2010) Mark E. Lobatto et al.   MOLECULAR PHARMACEUTICS

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways

(2010) T. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What have we learnt from targeted anti-TNF therapy?

(2009) M Feldmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Inactivation of the Adenosine A 2A Receptor Protects Apolipoprotein E–Deficient Mice From Atherosclerosis

(2009) Huan Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of p38: Has the fat lady sung?

(2009) Mark C. Genovese   ARTHRITIS AND RHEUMATISM

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT)

(2009) PAUL M. RIDKER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Innate Immune Responses to Danger Signals in Systemic Inflammatory Response Syndrome and Sepsis

(2009) A. Castellheim et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Update on statin-mediated anti-inflammatory activities in atherosclerosis

(2009) Fabrizio Montecucco et al.   Seminars in Immunopathology

Autoimmunity in atherosclerosis: a protective response losing control?

(2008) J. Nilsson et al.   JOURNAL OF INTERNAL MEDICINE