mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice

HIPK family kinases bind and regulate the function of the CCR4-NOT complex

(2016) Alfonso Rodriguez-Gil et al.   MOLECULAR BIOLOGY OF THE CELL

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age

(2015) Cristal M. Hill et al.   AGE

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

mTORC1 signaling activates NRF1 to increase cellular proteasome levels

(2015) Yinan Zhang et al.   CELL CYCLE

Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice

(2015) Graham Dominick et al.   ENDOCRINOLOGY

Ccr4-Not Regulates RNA Polymerase I Transcription and Couples Nutrient Signaling to the Control of Ribosomal RNA Biogenesis

(2015) R. Nicholas Laribee et al.   PLoS Genetics

Gene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction

(2015) Zhen Yu et al.   SpringerPlus

Multi-Functional Regulation of 4E-BP Gene Expression by the Ccr4-Not Complex

(2015) Hirokazu Okada et al.   PLoS One

Repair of endogenous DNA base lesions modulate lifespan in mice

(2014) Lisiane B. Meira et al.   DNA REPAIR

Progression of O6-methylguanine-DNA methyltransferase and temozolomide resistance in cancer research

(2014) Guan Jiang et al.   MOLECULAR BIOLOGY REPORTS

mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells

(2014) Sarah Smalley et al.   Molecular Cancer

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects

(2014) Claudia Temme et al.   Frontiers in Genetics

Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation

(2014) Toshifumi Inada et al.   Frontiers in Genetics

Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena

(2014) Yo-Taro Shirai et al.   Frontiers in Genetics

Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

(2013) Gabriele De Luca et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes

(2013) Xinna Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

(2013) Elwira Strozyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

(2013) M. Weiler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Augmented autophagy pathways and MTOR modulation in fibroblasts from long-lived mutant mice

(2012) Min Wang et al.   Autophagy

The control of elongation by the yeast Ccr4–Not complex

(2012) Joseph C. Reese   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

GH and IGF1: Roles in Energy Metabolism of Long-Living GH Mutant Mice

(2012) H. M. Brown-Borg et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5′ short ORFs

(2012) Hayet Ait Ghezala et al.   NUCLEIC ACIDS RESEARCH

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice

(2011) Ruqiang Liang et al.   AGING CELL

Obesity resistance and increased hepatic expression of catabolism-related mRNAs inCnot3+/−mice

(2011) Masahiro Morita et al.   EMBO JOURNAL

Liver-Derived IGF-I Regulates Mean Life Span in Mice

(2011) Johan Svensson et al.   PLoS One

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging

(2009) David J. Bates et al.   AGING CELL

Minireview: Posttranscriptional Regulation of the Insulin and Insulin-Like Growth Factor Systems

(2009) Eun Kyung Lee et al.   ENDOCRINOLOGY

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings

(2008) Andrzej Bartke   AGING CELL

hCCR4/cNOT6 targets DNA-damage response proteins

(2008) I. Sanchez-Perez et al.   CANCER LETTERS

Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues

(2007) William R. Swindell   MECHANISMS OF AGEING AND DEVELOPMENT