Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri

(2019) Hideaki Matsui et al.   Cell Reports

Lysosomal Dysfunction at the Centre of Parkinson’s Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis

(2019) Rebecca L. Wallings et al.   TRENDS IN NEUROSCIENCES

The African turquoise killifish: A research organism to study vertebrate aging and diapause

(2018) Chi-Kuo Hu et al.   AGING CELL

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

(2018) Hrvoje Augustin et al.   NEUROBIOLOGY OF AGING

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

(2018) Peer Aramillo Irizar et al.   Nature Communications

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

(2018) Ivonne Heinze et al.   BMC BIOLOGY

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Widespread Accumulation of Ribosome-Associated Isolated 3′ UTRs in Neuronal Cell Populations of the Aging Brain

(2018) Peter H. Sudmant et al.   Cell Reports

The role of mitochondrial ROS in the aging brain

(2017) Rhoda Stefanatos et al.   FEBS LETTERS

Transcriptional profiling reveals protective mechanisms in brains of long-lived mice

(2017) Christiane Frahm et al.   NEUROBIOLOGY OF AGING

UBE2O is a quality control factor for orphans of multiprotein complexes

(2017) Kota Yanagitani et al.   SCIENCE

What have we learned on aging from omics studies?

(2017) Alessandro Cellerino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The crucial impact of lysosomes in aging and longevity

(2016) Didac Carmona-Gutierrez et al.   AGEING RESEARCH REVIEWS

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

(2016) Erik McShane et al.   CELL

A Ribosomal Perspective on Proteostasis and Aging

(2016) Kristan K. Steffen et al.   Cell Metabolism

The short-lived African turquoise killifish: an emerging experimental model for ageing

(2016) Yumi Kim et al.   Disease Models & Mechanisms

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

(2016) Ingo Braasch et al.   NATURE GENETICS

Nothobranchius furzeri : A Model for Aging Research and More

(2016) Matthias Platzer et al.   TRENDS IN GENETICS

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

(2016) Min-Kyung Sung et al.   eLife

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan

(2016) Mario Baumgart et al.   Cell Systems

From the bush to the bench: the annualNothobranchiusfishes as a new model system in biology

(2015) Alessandro Cellerino et al.   BIOLOGICAL REVIEWS

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish

(2015) Kathrin Reichwald et al.   CELL

A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

(2015) Itamar Harel et al.   CELL

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

The s2D Method: Simultaneous Sequence-Based Prediction of the Statistical Populations of Ordered and Disordered Regions in Proteins

(2015) Pietro Sormanni et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the human 80S ribosome

(2015) Heena Khatter et al.   NATURE

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Protein biogenesis machinery is a driver of replicative aging in yeast

(2015) Georges E Janssens et al.   eLife

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

(2015) Yu-Ning Wei et al.   GENOME BIOLOGY

Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats

(2015) Alessandro Ori et al.   Cell Systems

RNA-seq of the aging brain in the short-lived fishN. furzeri- conserved pathways and novel genes associated with neurogenesis

(2014) Mario Baumgart et al.   AGING CELL

The cleverSuite approach for protein characterization: predictions of structural properties, solubility, chaperone requirements and RNA-binding abilities

(2014) Petr Klus et al.   BIOINFORMATICS

Proteasome activation delays aging in vitro and in vivo

(2014) Niki Chondrogianni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Widespread splicing changes in human brain development and aging

(2013) P. Mazin et al.   Molecular Systems Biology

Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines

(2013) A. Ori et al.   Molecular Systems Biology

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome

(2012) Shona H. Wood et al.   AGE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Dendritic spine changes associated with normal aging

(2012) D.L. Dickstein et al.   NEUROSCIENCE

Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes

(2012) Sang Mi Shim et al.   Cell Reports

Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

(2011) Pedro Reis-Rodrigues et al.   AGING CELL

Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging

(2011) Eva Terzibasi Tozzini et al.   AGING CELL

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

(2011) Carlo Colantuoni et al.   NATURE

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias

(2010) Emiliano Di Cicco et al.   EXPERIMENTAL GERONTOLOGY

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

(2010) M. Somel et al.   GENOME RESEARCH

Gene expression in the hippocampus: Regionally specific effects of aging and caloric restriction

(2010) Zane Zeier et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

ShortRead: a bioconductor package for input, quality assessment and exploration of high-throughput sequence data

(2009) M. Morgan et al.   BIOINFORMATICS

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

Accurate and Sensitive Peptide Identification with Mascot Percolator

(2009) Markus Brosch et al.   JOURNAL OF PROTEOME RESEARCH

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Accurate whole human genome sequencing using reversible terminator chemistry

(2008) David R. Bentley et al.   NATURE

Evolution of the Aging Brain Transcriptome and Synaptic Regulation

(2008) Patrick M. Loerch et al.   PLoS One

Large Differences in Aging Phenotype between Strains of the Short-Lived Annual Fish Nothobranchius furzeri

(2008) Eva Terzibasi et al.   PLoS One