Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer’s Disease Cooperative Study-Sponsored DHA Clinical Trial

(2020) Natalie Tomaszewski et al.   JOURNAL OF ALZHEIMERS DISEASE

Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype

(2020) Jacob S. Friedberg et al.   Scientific Reports

Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

(2020) Na Zhao et al.   NEURON

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

(2020) Nikos Koundouros et al.   CELL

The Role of MAPK`s Signaling in Mediating ApoE4-Driven Pathology in vivo

(2019) Shiran Salomon-Zimri et al.   Current Alzheimer Research

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

(2019) Annamaria Vezzani et al.   Nature Reviews Neurology

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

(2019) Chun-Cheih Chao et al.   CELL

Targeting Cytosolic Phospholipase A2α for Novel Anti-Inflammatory Agents

(2018) Jalal Soubhye et al.   CURRENT MEDICINAL CHEMISTRY

The phospholipase A2pathway controls a synaptic cholesterol ester cycle and synapse damage

(2018) Craig Osborne et al.   JOURNAL OF CELL SCIENCE

Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures

(2018) Clive Bate et al.   NEUROBIOLOGY OF DISEASE

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease

(2018) Philip Scheltens et al.   Annals of Clinical and Translational Neurology

EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer’s disease

(2017) Leon M. Tai et al.   JOURNAL OF LIPID RESEARCH

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner

(2017) Juan Pablo Palavicini et al.   Acta Neuropathologica Communications

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Prostaglandins from Cytosolic Phospholipase A2α/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression inCandida albicans-infected Macrophages

(2016) Bogeon Yun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglial immunophenotype in dementia with Alzheimer’s pathology

(2016) Thais Minett et al.   Journal of Neuroinflammation

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease

(2016) Hussein N. Yassine et al.   Alzheimers Research & Therapy

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

APOε4 is associated with enhanced in vivo innate immune responses in human subjects

(2014) Stephen C. Gale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2activity in Alzheimer's disease

(2013) Alfred N. Fonteh et al.   JOURNAL OF LIPID RESEARCH

Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A2-VIA (iPLA2β)-knockout mice

(2012) Yewon Cheon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of cytosolic Phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin

(2012) Victoria Last et al.   BMC NEUROSCIENCE

APOE genotype alters glial activation and loss of synaptic markers in mice

(2012) Yuangui Zhu et al.   GLIA

Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

(2012) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

Role of Cytosolic Calcium-Dependent Phospholipase A2 in Alzheimer's Disease Pathogenesis

(2012) M. T. Gentile et al.   MOLECULAR NEUROBIOLOGY

Integrating Cytosolic Phospholipase A2 with Oxidative/Nitrosative Signaling Pathways in Neurons: A Novel Therapeutic Strategy for AD

(2012) Grace Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Critical role of cPLA2 in Aβ oligomer-induced neurodegeneration and memory deficit

(2011) Cédric Desbène et al.   NEUROBIOLOGY OF AGING

Dissociating  -Amyloid from  7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes  7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain

(2009) H.-Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

(2008) G. Esposito et al.   JOURNAL OF NUCLEAR MEDICINE

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING