Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): new perspectives for a fairy-tale ending?

Bnip3 in mitophagy: novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction

(2020) Anbo Gao et al.   CLINICA CHIMICA ACTA

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes

(2020) Marica Meroni et al.   EBioMedicine

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

(2020) Meng Li et al.   Cells

A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease

(2020) Yujia Liu et al.   Cells

Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice

(2020) Kelly N. Z. Fuller et al.   JOURNAL OF APPLIED PHYSIOLOGY

Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD

(2020) Shuoyi Ma et al.   LIVER INTERNATIONAL

Sustained mitochondrial biogenesis is essential to maintain caloric restriction-induced beige adipocytes

(2020) Raja Gopal Reddy Mooli et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis

(2020) Tingting Yang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Absence of AGPAT2 impairs brown adipogenesis, increases IFN stimulated gene expression and alters mitochondrial morphology

(2020) Pablo J. Tapia et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Aerobic Exercise Training Exerts Beneficial Effects Upon Oxidative Metabolism and Non-Enzymatic Antioxidant Defense in the Liver of Leptin Deficiency Mice

(2020) Matheus Santos de Sousa Fernandes et al.   Frontiers in Endocrinology

Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials

(2020) Sahar Rafiee et al.   Complementary Therapies in Clinical Practice

ER-mitochondria interactions: Both strength and weakness within cancer cells

(2019) Mabrouka Doghman-Bouguerra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

(2019) Daniel Garcia et al.   Cell Reports

Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy

(2019) Tao Zhou et al.   Redox Biology

Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression

(2019) Dengke Bao et al.   ONCOGENE

Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis

(2019) Ning-Ping Zhang et al.   LABORATORY INVESTIGATION

AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model

(2019) Liangshuo Hu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity.

(2019) Colin S. McCoin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

(2019) Soumik BasuRay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma

(2019) Eunus S. Ali et al.   CELL CALCIUM

YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis

(2019) Tingting Yang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease

(2019) Meng Jiang et al.   Frontiers in Endocrinology

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming

(2019) Ze Zhang et al.   BRITISH JOURNAL OF CANCER

Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

(2019) David Kung-Chun Chiu et al.   Cell Death & Disease

SnapShot: Mitochondrial Nucleoid

(2018) Nina A. Bonekamp et al.   CELL

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle

(2018) John Wood et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Yap promotes hepatocellular carcinoma metastasis and mobilization via governing cofilin/F-actin/lamellipodium axis by regulation of JNK/Bnip3/SERCA/CaMKII pathways

(2018) Chen Shi et al.   Redox Biology

Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling

(2018) Carly S. Cox et al.   Cell Metabolism

FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation

(2018) Wenhui Li et al.   HEPATOLOGY

Mitochondrial dysfunction-related lipid changes occur in non-alcoholic fatty liver disease progression

(2018) Kang-Yu Peng et al.   JOURNAL OF LIPID RESEARCH

Increased serum concentration of ceramides in obese children with nonalcoholic fatty liver disease

(2018) Natalia Wasilewska et al.   Lipids in Health and Disease

Genetic and Epigenetic Modifiers of Alcoholic Liver Disease

(2018) Marica Meroni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models

(2018) Ashfaq Ahmad et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators

(2018) Elena Piccinin et al.   Nature Reviews Gastroenterology & Hepatology

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2018) Zobair M. Younossi et al.   TRANSPLANTATION

Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid–induced insulin resistance

(2017) Satoko Shinjo et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

(2017) Huiqin Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease

(2017) Aurèle Besse-Patin et al.   GASTROENTEROLOGY

TM6SF2 rs58542926 impacts lipid processing in liver and small intestine

(2017) Elizabeth A. O'Hare et al.   HEPATOLOGY

Pioglitazone-induced improvements in insulin sensitivity occur without concomitant changes in muscle mitochondrial function

(2017) Sudip Bajpeyi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

(2017) Kai Liu et al.   MOLECULAR CELL

Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies

(2017) Nishanth E. Sunny et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitotherapy for Fatty Liver by Intravenous Administration of Exogenous Mitochondria in Male Mice

(2017) Ailing Fu et al.   Frontiers in Pharmacology

Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes

(2017) Charles Thivolet et al.   PLoS One

Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity

(2016) Rainey E. Patterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis

(2016) Inês O. Gonçalves et al.   Applied Physiology Nutrition and Metabolism

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

(2016) Qichao Huang et al.   Autophagy

The role of mitochondrial genomics in patients with non-alcoholic steatohepatitis (NASH)

(2016) Rohini Mehta et al.   BMC Medical Genetics

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

(2016) Gang Cheng et al.   CANCER RESEARCH

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

(2016) Sameer S. Kulkarni et al.   DIABETES

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

(2016) V. Martínez-Cisuelo et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles

(2016) Rosalind F. Roberts et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inactivation ofTm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

(2016) Eriks Smagris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma

(2016) Lei Zhan et al.   Oncotarget

SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

(2016) Yuming Li et al.   Oncotarget

Mitophagy, mitochondrial spheroids, and mitochondrial-derived vesicles in alcohol-induced liver injury

(2015) Jessica A. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitophagy in steatotic hepatocytes of ethanol-treated wild-type and Parkin knockout mice

(2015) Nabil Eid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice

(2015) Jessica A. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

(2015) Weilin Wang et al.   CANCER LETTERS

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

(2015) Lixiang Wang et al.   DIABETOLOGIA

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis

(2015) Li Wang et al.   HEPATOLOGY

Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009

(2015) Zobair M. Younossi et al.   HEPATOLOGY

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

(2015) Paola Dongiovanni et al.   Biomed Research International

FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway

(2014) S. Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells

(2014) Hae-Ki Min et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease

(2014) Chad A. Galloway et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage

(2014) Krishna S. Tummala et al.   CANCER CELL

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway

(2014) Santiago Vernia et al.   Cell Metabolism

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Inhibition of Akt Phosphorylation Diminishes Mitochondrial Biogenesis Regulators, Tricarboxylic Acid Cycle Activity and Exacerbates Recognition Memory Deficit in Rat Model of Alzheimer’s Disease

(2014) Fatemeh Shaerzadeh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization

(2014) Alan R. Kimmel et al.   CURRENT OPINION IN LIPIDOLOGY

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets

(2014) Ffolliott M. Fisher et al.   GASTROENTEROLOGY

PNPLA3 mediates hepatocyte triacylglycerol remodeling

(2014) Hanna Ruhanen et al.   JOURNAL OF LIPID RESEARCH

TheUCP2-866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

(2014) Roberta Fares et al.   LIVER INTERNATIONAL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondriacristaeand ER contacts in the postprandial liver

(2014) Aditi Sood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)

(2014) John J. Lemasters   Redox Biology

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease

(2013) Sabrina Krautbauer et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Hepatic-specific activation of peroxisome proliferator-activated receptor γ coactivator-1β protects against steatohepatitis

(2013) Elena Bellafante et al.   HEPATOLOGY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Association between Serum Atypical Fibroblast Growth Factors 21 and 19 and Pediatric Nonalcoholic Fatty Liver Disease

(2013) Anna Alisi et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion

(2012) E. Matthew Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response

(2012) Alberto Camacho et al.   EXPERIMENTAL NEUROLOGY

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

(2012) Bo Wang et al.   HEPATOLOGY

Dynamic Adaptation of Liver Mitochondria to Chronic Alcohol Feeding in Mice

(2012) Derick Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship of -55C/T Polymorphism of Uncoupling Protein 3 (UCP3) Gene with Metabolic Syndrome by ATP III Classification

(2012) Daniel Antonio de Luis et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma

(2012) Xiangxuan Zhao et al.   LABORATORY INVESTIGATION

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

(2012) D. Glick et al.   MOLECULAR AND CELLULAR BIOLOGY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Insulin Resistance and Metabolic Hepatocarcinogenesis with Parent-of-Origin Effects in A×B Mice

(2011) Ian N. Hines et al.   AMERICAN JOURNAL OF PATHOLOGY

The ER–mitochondria interface: The social network of cell death

(2011) Stefan Grimm   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PGC1  Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

(2011) K. Bhalla et al.   CANCER RESEARCH

Separation of the gluconeogenic and mitochondrial functions of PGC-1  through S6 kinase

(2011) Y. Lustig et al.   GENES & DEVELOPMENT

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies

(2011) Ahmad Al-Serri et al.   JOURNAL OF HEPATOLOGY

PKA/AKAP1 and PP2A/B 2 Regulate Neuronal Morphogenesis via Drp1 Phosphorylation and Mitochondrial Bioenergetics

(2011) A. S. Dickey et al.   JOURNAL OF NEUROSCIENCE

Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice

(2011) Michal Aharoni-Simon et al.   LABORATORY INVESTIGATION

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Association of the Sirtuin and Mitochondrial Uncoupling Protein Genes with Carotid Plaque

(2011) Chuanhui Dong et al.   PLoS One

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet

(2010) Nishanth E. Sunny et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity

(2010) Jia Li et al.   Cell Metabolism

Population-based risk factors and resource utilization for HCC: US perspective

(2010) A. Sanyal et al.   CURRENT MEDICAL RESEARCH AND OPINION

Mitochondrial shape changes: orchestrating cell pathophysiology

(2010) Silvia Campello et al.   EMBO REPORTS

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia

(2010) Julieta Carabelli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease

(2010) Sweta Tandra et al.   JOURNAL OF HEPATOLOGY

Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid–induced up-regulation of mitofusin 2

(2010) Yong Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Plasma metabolomic profile in nonalcoholic fatty liver disease

(2010) Satish C. Kalhan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis

(2009) Valérie Paradis et al.   HEPATOLOGY

Somatic mutations of mitochondrial genome in hepatocellular carcinoma

(2009) Pen-Hui Yin et al.   MITOCHONDRION

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The common −55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population

(2008) Taku Hamada et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE