Article
Biochemistry & Molecular Biology
Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: The study shows that deficiency of P2Y2R can improve NAFLD induced by high-fat diet through various pathways, including enhancing insulin resistance, inhibiting hepatic lipid accumulation and injury, reducing fatty acid synthesis, and increasing fatty acid oxidation. This suggests that P2Y2R may be a promising therapeutic target for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Ana Magdalena Velazquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lazaro, Jose Rodriguez-Morato, Rosa M. Sanchez, Marta Alegret, Nuria Roglans, Juan Carlos Laguna
Summary: This study aims to determine the role of dietary saturated fatty acids (FA) versus liquid fructose in the development of fatty liver and hypertriglyceridemia. The results show that adding liquid fructose to the diet plays a decisive role in the accumulation of liver fat and production of high triglycerides, through increased de novo lipogenesis and reduced fatty acid catabolism.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yue Xiong, Yan Chen, Xinping Huang, Zhen Yang, Jiaye Zhang, Xiaorui Yu, Ji Fang, Jiawang Tao, Kai You, Ziqi Cheng, Shenglin Tan, Yingying Xu, Fang Yuan, Ying Liu, Yuanqi Zhuang, Fan Yang, Yinxiong Li
Summary: Icaritin was found to have inhibitory effects on lipotoxicity and steatosis both in vitro and in vivo, mainly through promoting fatty acid oxidation and mitochondrial respiration while reducing fatty acid synthesis. ICT also significantly alleviated metabolic disorders and hepatic steatosis induced by a high-fat diet, potentially via upregulation of PPAR alpha and modulation of AKT and GSK3 beta activity.
Article
Plant Sciences
Ling Zhang, Ning Chen, Libin Zhan, Tingting Bi, Wen Zhou, Lijing Zhang, Lianlian Zhu
Summary: This study investigates the therapeutic effect and molecular mechanism of Erchen decoction (ECD) in a rat model of high-fat diet-induced obesity. The results demonstrate that ECD treatment improves lipid metabolic disorders and hepatic steatosis. Furthermore, ECD promotes the abundance of beneficial bacteria that produce short-chain fatty acids and reduces the abundance of disease-related bacteria. ECD also increases total short-chain fatty acids levels, particularly butyric acid. The mechanism may involve an increase in acetyl-histone 3-lysine 9 levels, promoting fatty acid beta-oxidation in the liver.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Jingyu Zhao, Meijuan Bai, Siying Wei, Chenchen Li, Qi Lv, Yan Chen
Summary: The intermittent application of a FMD, with low carbohydrate/protein content and high dietary fiber, can reduce obesity and glucose intolerance induced by a high-fat high-sucrose diet in mice. It also decreases adipocyte size, increases expression of lipolysis genes and HSL protein in white adipose tissue, and reduces HFHSD-induced lipid accumulation in the liver. RNA sequencing shows elevated expression of genes involved in fatty acid oxidation with FMD intervention.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yanyong Xu, Xiaoli Pan, Shuwei Hu, Yingdong Zhu, Fathima Cassim Bawa, Yuanyuan Li, Liya Yin, Yanqiao Zhang
Summary: Human CES2 plays a crucial role in protecting and reversing steatohepatitis by inducing lipolysis and fatty acid oxidation, inhibiting lipogenesis, and improving mitochondrial function. Targeting hepatic CES2 may be a promising strategy for treating NAFLD.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaiyang Ma, Weixi Sheng, Xinxin Song, Jiangfeng Song, Ying Li, Wuyang Huang, Yuanfa Liu
Summary: This study found that chlorogenic acid from burdock root can reduce the number of lipid droplets and lipid levels in HepG2 cells with steatosis. It activates the AMPK-related signaling pathways to enhance CPT-1 expression and increase the concentrations of Ca2+ and cAMP. Additionally, it enhances beta-oxidation of fatty acids, reduces alanine transaminase and aspartate transaminase, and inhibits apoptosis in HepG2 cells with steatosis.
Article
Multidisciplinary Sciences
Vincenza Cifarelli, Sila Appak-Baskoy, Vivek S. Peche, Andrew Kluzak, Trevor Shew, Ramkumar Narendran, Kathryn M. Pietka, Marina Cella, Curtis W. Walls, Rafael Czepielewski, Stoyan Ivanov, Gwendalyn J. Randolph, Hellmut G. Augustin, Nada A. Abumrad
Summary: Genetic variants in CD36 impact lymphatic lipid transport, while deficiency of CD36 in lymphatic endothelial cells leads to risks associated with metabolic syndrome and diabetes. The loss of CD36 in mice causes lymph leakage, visceral adiposity and glucose intolerance, increasing the risk of type 2 diabetes (T2D).
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Pan Li, Ruoyu Zhang, Meng Wang, Yuwei Chen, Zhiwei Chen, Xiumei Ke, Ling Zuo, Jianwei Wang
Summary: Baicalein (BAL), a compound extracted from Traditional Chinese Medicine, has potential therapeutic effects for liver diseases. The study found that BAL improved fructose-induced hepatic steatosis by regulating fatty acid synthesis, elongation, and oxidation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Kari D. Pilolla, Jessie Armendariz, Boe M. Burrus, David S. Baston, Karli A. McCarthy, Taylor K. Bloedon
Summary: Wild blueberries have been found to increase fat oxidation rate and decrease carbohydrate oxidation rate during moderate-intensity exercise. They have also been shown to reduce oxidative stress and influence lipolytic enzymes.
Article
Food Science & Technology
Hyo-Geun Lee, Min-Cheol Kang, You-Jin Jeon, Young-Sang Kim
Summary: This study investigated the In vitro lipid inhibitory effects of sulfated polysaccharide fractions derived from Sargassum thunbergii and found that it has a beneficial effect on intracellular lipid metabolism, suggesting its potential as a functional ingredient in the functional food industry.
Article
Pharmacology & Pharmacy
Guanjie Liu, Ling Chang, Yihan Qian, Jiacheng Lin, Zhi Shang, Min Xu, Fang Wang, Xuehua Sun, Yun Jiang, Yueqiu Gao, Xiaoni Kong
Summary: The study found that Polygonum perfoliatum L. (PPL) can protect against hepatic steatosis, lipid peroxidation, and glucose-lipid metabolism dysfunction in NAFLD mice. This is achieved through altering the PPARs/CPT1A/CPT2-mediated hepatic fatty acid beta-oxidation process. The active components of PPL with anti-NAFLD activity were identified using UPLC/QE-HFX.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sylwia Szrok-Jurga, Aleksandra Czumaj, Jacek Turyn, Areta Hebanowska, Julian Swierczynski, Tomasz Sledzinski, Ewa Stelmanska
Summary: Fatty acid metabolism, especially beta-oxidation, plays a crucial role in human physiology and pathology. Beta-oxidation is not only involved in energy metabolism but also contributes to the synthesis of various important compounds. This review provides an overview of the importance of mitochondrial and peroxisomal beta-oxidation in different organs and cells and discusses the diseases associated with fatty acid oxidation disturbances. The review also highlights the abnormalities of fatty acid oxidation in cancer cells and diseases caused by mutations in enzymes involved in fatty acid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Angen Yu, Yichuang Xu, Christer Hogstrand, Tao Zhao, Xiao-Ying Tan, Xiaolei Wei, Yu-Feng Song, Zhi Luo
Summary: Excessive dietary phosphate intake induces lipid degradation through the activation of the Klf4-Sirt3/Ppar alpha-Lcad pathway in the intestine and primary intestinal epithelial cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Microbiology
Hyeonji Kim, Kippeum Lee, Ju-Yeon Kim, Jae-Jung Shim, Junghyun Lim, Joo-Yun Kim, Jung-Lyoul Lee
Summary: Lactiplantibacillus plantarum LP158, Lactobacillus helveticus HY7804, and Lacticaseibacillus paracasei LPC226 isolated from raw milk have been shown to alleviate non-alcoholic fatty acid disease (NAFLD). These strains inhibit fatty acid accumulation, modulate gene expression related to lipogenesis and beta-oxidation, and improve blood biochemistry markers and liver steatosis in a mouse model of NAFLD. HY7804 exhibits the strongest effects both in vitro and in vivo, suggesting its potential as a supplement for NAFLD treatment.