The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease

CD200 maintains the region‐specific phenotype of microglia in the midbrain and its role in Parkinson's disease

(2020) Le Wang et al.   GLIA

Microglia and Parkinson's disease: footprints to pathology

(2020) Ekaterina Lazdon et al.   JOURNAL OF NEURAL TRANSMISSION

Identification of the CD200R1 promoter and the association of its polymorphisms with the risk of Parkinson’s disease

(2020) S. Lin et al.   EUROPEAN JOURNAL OF NEUROLOGY

Parkinsonian neurotoxicants impair the anti-inflammatory response induced by IL4 in glial cells: involvement of the CD200-CD200R1 ligand-receptor pair

(2020) Neus Rabaneda-Lombarte et al.   Scientific Reports

CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke

(2019) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats

(2019) Hao Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

(2019) Cai-Yun Liu et al.   Frontiers in Cellular Neuroscience

Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice

(2018) Kai Yao et al.   EXPERIMENTAL GERONTOLOGY

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

(2018) Vittorio Calabrese et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice

(2018) Yang Yang et al.   NEUROSCIENCE LETTERS

Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

(2018) Géraldine Gelders et al.   Journal of Immunology Research

Nonsteroidal anti-inflammatory drugs use and risk of Parkinson disease

(2018) Li Ren et al.   MEDICINE

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Microglial Implication in Parkinson’s Disease: Loss of Beneficial Physiological Roles or Gain of Inflammatory Functions?

(2018) Cynthia Lecours et al.   Frontiers in Cellular Neuroscience

Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation

(2018) Gemma Manich et al.   NEUROSCIENCE

Monocytes, microglia, and CD200-CD200R1 signaling are essential in the transmission of inflammation from the periphery to the central nervous system

(2017) Xin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages

(2017) Tony Valente et al.   Frontiers in Cellular Neuroscience

CD200Fc reduces TLR4-mediated inflammatory responses in LPS-induced rat primary microglial cells via inhibition of the NF-κB pathway

(2016) Li Jiang et al.   INFLAMMATION RESEARCH

CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model

(2016) Miriam Hernangómez et al.   Journal of Neuroinflammation

Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System

(2016) B.-W. Kim et al.   JOURNAL OF NEUROSCIENCE

CD200 Inhibits Inflammatory Response by Promoting KATP Channel Opening in Microglia Cells in Parkinson’s Disease

(2016) Yi Ren et al.   MEDICAL SCIENCE MONITOR

Protective Microglia and Their Regulation in Parkinson’s Disease

(2016) Weidong Le et al.   Frontiers in Molecular Neuroscience

Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation

(2015) Emiliano Peña-Altamira et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease

(2015) Megan M. Varnum et al.   NEUROBIOLOGY OF AGING

NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease

(2015) Haiyun Suo et al.   NEUROPHARMACOLOGY

Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation

(2015) Jie Liu et al.   Scientific Reports

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

(2014) X. Hu et al.   JOURNAL OF IMMUNOLOGY

Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

(2014) Augusta Pisanu et al.   NEUROBIOLOGY OF DISEASE

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms

(2013) Celine Perier et al.   BRAIN

MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA-pretreated mice

(2013) Giulia Costa et al.   MOVEMENT DISORDERS

Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol

(2013) Mohammad Moshahid Khan et al.   NEUROCHEMISTRY INTERNATIONAL

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

Regulation of microglia activation and deactivation by nuclear receptors

(2012) Kaoru Saijo et al.   GLIA

CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation

(2012) Miriam Hernangómez et al.   GLIA

Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia

(2012) Anthony Lyons et al.   Journal of Neuroinflammation

Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/ -Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair

(2012) F. L'Episcopo et al.   JOURNAL OF NEUROSCIENCE

Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice

(2012) Yun-Hee Sung et al.   LIFE SCIENCES

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

(2012) S. Iannaccone et al.   PARKINSONISM & RELATED DISORDERS

Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice

(2012) Minjuan Bian et al.   PLoS One

CD200 fusion protein decreases microglial activation in the hippocampus of aged rats

(2011) F. Fionnuala Cox et al.   BRAIN BEHAVIOR AND IMMUNITY

Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation

(2011) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

(2011) Shi Zhang et al.   Journal of Neuroinflammation

Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model

(2011) A.R. Carta et al.   NEUROSCIENCE

Neurotoxin-based models of Parkinson's disease

(2011) J. Bové et al.   NEUROSCIENCE

Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson's Disease

(2010) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

CD200R1 Agonist Attenuates Mechanisms of Chronic Disease in a Murine Model of Multiple Sclerosis

(2010) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF

(2010) Zhiqi Chen et al.   NUCLEIC ACIDS RESEARCH

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

(2009) Claire Gibrat et al.   JOURNAL OF NEUROCHEMISTRY

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions

(2009) Nathalie Koning et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

(2008) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

CNS inflammation and neuronal degeneration is aggravated by impaired CD200–CD200R-mediated macrophage silencing

(2008) Sven G. Meuth et al.   JOURNAL OF NEUROIMMUNOLOGY

Curcumin Protects Dopaminergic Neuron Against LPS Induced Neurotoxicity in Primary Rat Neuron/Glia Culture

(2008) Sufen Yang et al.   NEUROCHEMICAL RESEARCH

Identification of an Expressed Truncated Form of CD200, CD200tr, which is a Physiologic Antagonist of CD200-Induced Suppression

(2008) Zhiqi Chen et al.   TRANSPLANTATION