Article
Pharmacology & Pharmacy
Youssef Abdalla, Ali Abdalla, Alaaeldin Ahmed Hamza, Amr Amin
Summary: This study found that safranal has chemopreventive effects against liver cancer and investigated its mechanisms of action. Safranal was found to significantly inhibit proliferation and induce apoptosis in both rat and human liver cancer cells, and it also exhibited anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Won Sik Eum, Dae Won Kim, Eun Ji Yeo, Hyeon Ji Yeo, Yeon Joo Choi, Hyun Ju Cha, Jinseu Park, Kyu Hyung Han, Duk-Soo Kim, Yeon Hee Yu, Sung-Woo Cho, Oh-Shin Kwon, Yong-Jun Cho, Min Jea Shin, Soo Young Choi
Summary: This study demonstrated that Tat-PRAS40 protects against dopaminergic neuronal cell death through various mechanisms and shows protective effects in a Parkinson's disease animal model.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
Ramona D'Amico, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Gianluca Franco, Ylenia Marino, Alessia Arangia, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: This study explores a new neuroprotective strategy for Parkinson's disease by supplementing with Acai berry. The results show that daily supplementation with Acai berry significantly reduces motor and non-motor symptoms and protects dopaminergic neurons from damage. This beneficial effect may be attributed to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) to counteract oxidative stress and neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Han-Kyeol Kim, Tae Won Kim, Min Seok Baek, Eung Yeop Kim, Young Hee Sung, Jae Hoon Lee, Young Hoon Ryu, Sung Jun Ahn, Han Soo Yoo, Chul Hyoung Lyoo
Summary: In this study, the visibility of NG1 in SMwI was found to be associated with the degree of nigrostriatal degeneration in PD patients. It was concluded that SMwI can be used for diagnosing PD only after the onset of motor symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Peripheral Vascular Disease
Yuan Li, Xiuzhi Yang, Qi Sun, Bide Duan, Yanyun Wang
Summary: Troxerutin treatment for gestational hypertension reduces blood pressure, inflammation, and oxidative stress in a dose-dependent manner. It also modulates cytokine expression, inhibits STAT3/RNF6 signaling, and shows potential therapeutic effects for gestational hypertension.
HYPERTENSION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Su Bin Cho, Won Sik Eum, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Sung-Woo Cho, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Duk-Soo Kim, Dae Won Kim, Soo Young Choi
Summary: The Tat-AR protein showed protective effects against MPP+-induced cell death in SH-SY5Y cells and inhibited dopaminergic neuronal cell death in a mouse model of PD. These findings suggest that Tat-AR may be a useful therapeutic protein for Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Xiaohang Zheng, Jianxin Qiu, Ning Gao, Ting Jiang, Ze Li, Weikang Zhang, Yuhang Gong, Zhenghua Hong, Huaxing Hong
Summary: Paroxetine can inhibit inflammation and reduce cartilage degradation and bone destruction, thereby delaying knee joint degeneration. Through in vitro and in vivo experiments, it was found that paroxetine can reduce the activation of inflammatory cytokines and bone resorption-related signaling pathways, as well as prevent the generation of inflammatory cells and cartilage degeneration.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sri Jayanti, Rita Moretti, Claudio Tiribelli, Silvia Gazzin
Summary: This study investigated the neuroprotective effect of low concentrations of UCB in a PD model and found that UCB could effectively protect against the loss of dopaminergic neurons, with inflammation being the key factor in this protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Sebile Azirak, Meltem Ozgocmen
Summary: Currently, kidney diseases are on the rise, leading to a decrease in quality of life. Acute kidney injury (AKI) is commonly seen in hospitalized patients of all ages and is associated with high morbidity and mortality rates. Rifampicin (RF), an antibiotic from the rifamycin group, can cause acute kidney injury as well as side effects such as anemia, thrombocytopenia, and liver damage. This study investigated the potential benefits of linalool (LN), which has antinociceptive, antimicrobial, antioxidant, and anti-inflammatory effects, in alleviating kidney damage caused by RF-induced oxidative stress.
Article
Biochemistry & Molecular Biology
Sheikh Azimullah, Richard L. Jayaraj, Mohamed Fizur. Nagoor Meeran, Fakhreya Y. Jalal, Abdu Adem, Shreesh Ojha, Rami Beiram
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons, resulting in motor deficits. The present study evaluated the role of myrcene in preventing the loss of dopaminergic neurons in a rodent model of PD and elucidated the underlying mechanisms.
Article
Neurosciences
Ingrid Morales, Ricardo Puertas-Avendano, Alberto Sanchez, Adrian Perez-Barreto, Clara Rodriguez-Sabate, Manuel Rodriguez
Summary: The study revealed the essential role of astrocytes in clearing axonal debris produced by the degeneration of dopaminergic axons, which can prevent the activation of microglia and hinder the progression of PD.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Khatija Ayoob, Seenipandi Arunachalam, Shreesh Ojha, Rami Beiram
Summary: Parkinson's disease (PD) is a movement disorder characterized by the degeneration of dopaminergic neurons in the brain. The etiopathogenesis of PD involves oxidative stress, inflammation, impaired autophagy, accumulation of a-synuclein, and a-Glutamate neurotoxicity. This study investigated the effect of tannic acid (TA) in a rodent model of PD induced by rotenone (ROT), and found that TA can reduce oxidative stress, inhibit inflammation, and protect dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yun-Mi Kim, Su Yeon Choi, Onyou Hwang, Joo-Yong Lee
Summary: This study investigated the potential neuroprotective effects of exogenous pyruvate in a mouse model of Parkinson's disease. The results showed that sodium pyruvate administration could protect nigral DA neurons from degeneration and alleviate the associated motor deficits, indicating its therapeutic potential for PD and related neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jiang-Peng Fan, Hui-Zhen Geng, Ya-Wei Ji, Tao Jia, Jennifer B. Treweek, An-An Li, Chun-Yi Zhou, Viviana Gradinaru, Cheng Xiao
Summary: Key components in the nigrostriatal DA system exhibit distinct aging patterns and may contribute to age-related alterations in locomotion and coordination.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)