The first copper(I) complex of anthrahydrazone with potential ROS scavenging activity showed significant in vitro anticancer activity by inducing apoptosis and autophagy

Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos

(2020) Golara Golbaghi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ABTS/PP Decolorization Assay of Antioxidant Capacity Reaction Pathways

(2020) Igor R. Ilyasov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidants and antioxidant methods: an updated overview

(2020) İlhami Gulcin   ARCHIVES OF TOXICOLOGY

Targeting drug delivery system for platinum(Ⅳ)-Based antitumor complexes

(2020) Yunshuang Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer boron-containing prodrugs responsive to oxidative stress from the tumor microenvironment

(2020) Hichem Maslah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Differences in Stability, Cytotoxicity, and Mechanism of Action of Ru(II) and Pt(II) Complexes of a Bidentate N,O Donor Ligand

(2020) Moumita Maji et al.   INORGANIC CHEMISTRY

The copper(II) complexes of new anthrahydrazone ligands: In vitro and in vivo antitumor activity and structure-activity relationship

(2020) Rui-Xue Liu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent in Vitro and in Vivo Anticancer Activity Against HCC

(2020) Mianli Bian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells

(2020) ZhaoMin Lin et al.   Cell Death & Disease

Ruthenium(II) Phosphine/Mercapto Complexes: Their in Vitro Cytotoxicity Evaluation and Actions as Inhibitors of Topoisomerase and Proteasome Acting as Possible Triggers of Cell Death Induction

(2020) Gabriel H. Ribeiro et al.   INORGANIC CHEMISTRY

New insights into the mechanisms of tartaric acid enhancing homogeneous and heterogeneous copper-catalyzed Fenton-like systems

(2020) Qian Ye et al.   JOURNAL OF HAZARDOUS MATERIALS

Therapeutic potential of targeting mitochondrial dynamics in cancer

(2020) Tiago Rodrigues et al.   BIOCHEMICAL PHARMACOLOGY

Hydroxy-corrole and its gallium(III) complex as new photosensitizer for photodynamic therapy against breast carcinoma

(2020) Yan-Mei Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondria-localizing N-heterocyclic thiosemicarbazone copper complexes with good cytotoxicity and high antimetastatic activity

(2019) ShanShan Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intracellular catalase activity instead of glutathione level dominates the resistance of cells to reactive oxygen species

(2019) Meng-Xin Zhao et al.   CELL STRESS & CHAPERONES

Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes

(2019) Rukhsana Anjum et al.   INORGANIC CHEMISTRY

Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell death

(2019) Sujit K. Bhutia et al.   PHARMACOLOGICAL RESEARCH

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines

(2019) Tânia Capelôa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Stereochemistry of Hexacoordinated Zn(II), Cu(II), Ni(II), and Co(II) Complexes with Iminodiacetamide Ligands

(2019) Natalija Pantalon Juraj et al.   INORGANIC CHEMISTRY

Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1

(2019) Mar Lorente et al.   JOURNAL OF CELL SCIENCE

Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents

(2019) Neife Aparecida Guinaim dos Santos et al.   FOOD AND CHEMICAL TOXICOLOGY

Copper(I) complexes with phosphines P(p-OCH3-Ph)2CH2OH and P(p-OCH3-Ph)2CH2SarGly. Synthesis, multimodal DNA interactions, and prooxidative and in vitro antiproliferative activity

(2019) Urszula K. Komarnicka et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, antiproliferative activity and mechanism of gallium(III)-thiosemicarbazone complexes as potential anti-breast cancer agents

(2018) Jinxu Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational design of mitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivity and antiproliferative activity

(2018) Biao Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial network responses in oxidative physiology and disease

(2018) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

(2018) Ke-Bin Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction

(2018) Zhongmin Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ganoderma tsugae induced ROS-independent apoptosis and cytoprotective autophagy in human chronic myeloid leukemia cells

(2018) You-Cheng Hseu et al.   FOOD AND CHEMICAL TOXICOLOGY

Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle

(2017) Jinxu Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives

(2017) Tatjana Lazarević et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption

(2017) Dan Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway

(2017) Shengtao Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cardiotoxic effects of anthracycline-based therapy: what is the evidence and what are the potential harms?

(2017) Bennett E Levis et al.   LANCET ONCOLOGY

Platinum coordination compounds with potent anticancer activity

(2017) Krishant M. Deo et al.   COORDINATION CHEMISTRY REVIEWS

Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

(2016) Chen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Four Cu(ii) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity

(2016) Ya-Hong Liu et al.   DALTON TRANSACTIONS

Copper complexes based on chiral Schiff-base ligands: DNA/BSA binding ability, DNA cleavage activity, cytotoxicity and mechanism of apoptosis

(2016) Xue-Quan Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions

(2016) Qi-Pin Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multifrequency cw-EPR and DFT Studies of an Apparent Compressed Octahedral Cu(II) Complex

(2016) Nikita Hall et al.   INORGANIC CHEMISTRY

Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy

(2016) Bin-Hsu Mao et al.   Nanotoxicology

Ruthenium(ii) arene complexes containing benzhydrazone ligands: synthesis, structure and antiproliferative activity

(2016) Mohamed Kasim Mohamed Subarkhan et al.   Inorganic Chemistry Frontiers

Isoquinoline derivatives Zn(II)/Ni(II) complexes: Crystal structures, cytotoxicity, and their action mechanism

(2015) Ke-Bin Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on anticancer potential of bioactive heterocycle quinoline

(2015) Obaid Afzal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor mechanisms of a copper(ii) complex of anthracene-9-imidazoline hydrazone (9-AIH)

(2015) Qi-Pin Qin et al.   Metallomics

GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells

(2015) I-Lun Hsin et al.   MOLECULAR PHARMACEUTICS

pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy

(2015) Yao-Xin Lin et al.   MOLECULAR PHARMACEUTICS

An integrated view of cisplatin-induced nephrotoxicity and ototoxicity

(2015) Takatoshi Karasawa et al.   TOXICOLOGY LETTERS

Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in p53-independent manner

(2014) Peng Li et al.   APOPTOSIS

Copper(I) halide complexes of 5-carbethoxy-2-thiouracil: Synthesis, structure and in vitro cytotoxicity

(2014) I. Papazoglou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cu(II) inhibits hIAPP fibrillation and promotes hIAPP-induced beta cell apoptosis through induction of ROS-mediated mitochondrial dysfunction

(2014) Lijuan Ma et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer Activity

(2014) Alexander G. Majouga et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prevention of Anthracycline-Induced Cardiotoxicity

(2014) Pimprapa Vejpongsa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

(2014) Tomáš Šimůnek et al.   Pharmacological Reports

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

The emerging role of acetylation in the regulation of autophagy

(2013) Ágnes Bánréti et al.   Autophagy

Flavonol isolated from ethanolic leaf extract ofThuja occidentalisarrests the cell cycle at G2-M and induces ROS-independent apoptosis in A549 cells, targeting nuclear DNA

(2013) A. Mukherjee et al.   CELL PROLIFERATION

Copper(II/I) complexes of 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline: Synthesis, crystal structure, antitumor activity and DNA interaction

(2013) Ke-Bin Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Mixed-Ligand Copper(I) Complexes: Role of Diimine Ligands on Cytotoxicity and Genotoxicity

(2013) Valentina Gandin et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-acetyl-L-cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells

(2013) Ming-Shun Wu et al.   MOLECULAR CARCINOGENESIS

Quinolines: a new hope against inflammation

(2012) Soumita Mukherjee et al.   DRUG DISCOVERY TODAY

Ternary Dinuclear Copper(II) Complexes of a Hydroxybenzamide Ligand with Diimine Coligands: the 5,6-dmp Ligand Enhances DNA Binding and Cleavage and Induces Apoptosis

(2011) Sethu Ramakrishnan et al.   INORGANIC CHEMISTRY

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

(2011) Christian R. Kowol et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Anthracyclines and ellipticines as DNA-damaging anticancer drugs: Recent advances

(2011) Rene Kizek et al.   PHARMACOLOGY & THERAPEUTICS