Article
Chemistry, Medicinal
Daniil V. Spector, Kirill G. Pavlov, Roman A. Akasov, Alexander N. Vaneev, Alexander S. Erofeev, Petr V. Gorelkin, Vita N. Nikitina, Elena V. Lopatukhina, Alevtina S. Semkina, Kseniya Yu. Vlasova, Dmitrii A. Skvortsov, Vitaly A. Roznyatovsky, Nikolay V. Ul'yanovskiy, Ilya I. Pikovskoi, Sergey A. Sypalov, Anastasiia S. Garanina, Stepan S. Vodopyanov, Maxim A. Abakumov, Yulia L. Volodina, Alina A. Markova, Albina S. Petrova, Dmitrii M. Mazur, Dmitry A. Sakharov, Nikolay V. Zyk, Elena K. Beloglazkina, Alexander G. Majouga, Olga O. Krasnovskaya
Summary: In this study, a series of novel Pt(IV) prodrugs with nonsteroidal anti-inflammatory drugs were designed and synthesized. By tuning the drug lipophilicity via variation of the axial ligands, the most potent Pt(IV) prodrug was obtained, showing enhanced cellular accumulation and cytotoxicity. The prodrugs exhibited superior antiproliferative activity compared to cisplatin and overcame tumor cell line resistance.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Barbora Mala, Laura E. Murtagh, Charlotte M. A. Farrow, Geoffrey R. Akien, Nathan R. Halcovich, Sarah L. Allinson, James A. Platts, Michael P. Coogan
Summary: This study reports the formation of dinuclear complexes from thiophenolate ligands, as well as the photochemical oxidation to sulfinates, leading to the discovery of tunable photophysics depending on the 1,2-diimine ligands. Different ligand conditions result in various types of complexes, with photooxidation yielding previously unreported Pt(IV)-SO2R complexes exhibiting multiple absorption characteristics.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Peter A. Ajibade, Fartisincha P. Andrew, Amos A. Fatokun, Abimbola E. Oluwalana
Summary: The complexes of Mn(II), Co(II), Cu(II), Zn(II), and Pt(II) with 2-(((4-methoxyphenyl)amino)methyl)phenolyl dithiocarbamato have been synthesized and characterized. In vitro screening showed that Co(II) and Zn(II) had the most potent anticancer effects on MRC5-SV2 cancer cells, providing a potential direction for further research on inorganic complexes as anticancer drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Electrochemistry
Oleg A. Levitskiy, Olga I. Aglamazova, Alena V. Dmitrieva, Tatiana V. Magdesieva
Summary: The electrochemical properties of a series of chiral Ni(II) Schiff-base complexes of beta-arylsulfanyl amino acids were investigated, revealing differences in potential values and follow-up steps for diastereomeric couples. The study showed that the stereoisomerism of the complexes can affect their electrochemical behavior.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Juan-Carlos Lopez-Lopez, Delia Bautista, Pablo Gonzalez-Herrero
Summary: The synthesis and photophysical properties of bis-cyclometalated halido(aryl) Pt(iv) complexes are reported. The introduction of aryl ligands through different methods and the comparison of chlorido and fluorido derivatives in terms of emission lifetimes and radiative rate constants are discussed. The study also highlights the role of radical species in the activation of solvents during the oxidative addition reaction.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Juan Sanchez-Camacho, Sonia Infante-Tadeo, Ana C. Carrasco, Stefano Scoditti, A'lvaro Martinez, Fabienne Barroso-Bujans, Emilia Sicilia, Ana M. Pizarro, Luca Salassa
Summary: In this study, two new asymmetric Pt(IV) derivatives were designed and synthesized, which could be effectively activated into toxic Pt(II) species by incubation with nicotinamide adenine dinucleotide, sodium ascorbate, and glutathione in the dark and under light irradiation. One of the derivatives displayed enhanced toxicity in MDA-MB-231 breast cancer cells preincubated with ascorbate, suggesting selective triggering of oxaliplatin generation through redox activation. Covalent binding of the flavin to the Pt complex was shown to be pivotal for this effect.
INORGANIC CHEMISTRY
(2023)
Editorial Material
Polymer Science
Alexander S. Novikov
Summary: Non-covalent interactions are a key topic in modern chemical science, with significant effects on the properties of polymers. This Special Issue collects fundamental and applied research papers focused on non-covalent interactions in polymer chemistry and related fields, including original research articles and comprehensive review papers. The scope of the Special Issue is broad, welcoming contributions on the synthesis, structure, functionality, and properties of polymer systems involving non-covalent interactions.
Article
Chemistry, Inorganic & Nuclear
Maite Noessler, David Hunger, Felix Reichert, Mario Winkler, Marc Reimann, Johannes Klein, Simon Suhr, Lisa Suntrup, Julia Beerhues, Martin Kaupp, Joris van Slageren, Biprajit Sarkar
Summary: This study focuses on the synthesis of metal complexes with fluorinated benzyl ligands and their co-crystallization with different solvents to investigate the effects on non-covalent interactions and the spin state of the metal ions. The study reveals the structure-property correlation between the fluorinated aromatic substituents on the ligand and the spin state of the metal complexes. Additionally, specific interactions in the secondary coordination sphere were examined, showing interesting stacking motifs and spin crossover.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Daniil Spector, Alexander Erofeev, Peter Gorelkin, Dmitry Skvortsov, Alexander Trigub, Alina Markova, Vita Nikitina, Nikolay Ul'yanovskiy, Alexander Shtil, Alevtina Semkina, Ksenia Vlasova, Nikolay Zyk, Alexander Majouga, Elena Beloglazkina, Olga Krasnovskaya
Summary: A design of Pt(iv) prodrugs with tumor cell targeting moieties leading to increased selectivity is of interest. Herein, we designed a novel Pt(iv) prodrugs with COX-inhibitor naproxen, long-chain hydrophobic stearic acid moiety and biotin as axial ligands. We have established that for Pt(iv) prodrugs with biotin and naproxen or stearate in axial position, the lipophilicity rather than biotin receptors expression is the main factor of cytotoxicity. We also monitored the reduction speed of Pt(iv) prodrug 3 with naproxen and biotin in axial positions in A549 cells using XANES and demonstrated that the prodrug gradually releases cisplatin within 20 hours of incubation.
DALTON TRANSACTIONS
(2023)
Article
Pharmacology & Pharmacy
Anife Ahmedova, Rositsa Mihaylova, Silviya Stoykova, Veronika Mihaylova, Nikola Burdzhiev, Viktoria Elincheva, Georgi Momekov, Denitsa Momekova
Summary: Pt(IV) complexes formed by linking pyrene butyric acid with cisplatin exhibit high anticancer potency against leukemia cells and multidrug-resistant derivatives, while showing low toxicity to healthy cells. The larger bis-pyrene complex is found to potentially be trapped in the cytoskeleton, limiting its cytotoxicity to adherent cells.
Article
Chemistry, Organic
Takanori Shibata, Natsumi Shiozawa, Shun Nishibe, Hideaki Takano, Satoshi Maeda
Summary: A chiral Pt(ii) complex was synthesized and used as an efficient catalyst for an intramolecular [4 + 2] cycloaddition reaction of biphenylenes, resulting in high yields and enantioselectivity at ambient temperature. DFT calculations revealed a Pt(ii)/(iv) cycle involving oxidative addition of biphenylene and C-C bond cleavage.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Debasish Dutta, Pranay Sharma, Rosa M. Gomila, Antonio Frontera, Miquel Barcelo-Oliver, Akalesh K. Verma, Trishnajyoti Baishya, Manjit K. Bhattacharyya
Summary: Two coordination compounds of Co(II) and Cu(II) were synthesized and characterized, revealing the presence of supramolecular assemblies and various non-covalent interactions. The compounds exhibited significant concentration dependent cytotoxicity in cancer cells with minimal effects on normal cells. Computational analysis provided insights into the structure and energy features of the compounds, and established a structure-activity relationship.
Article
Chemistry, Inorganic & Nuclear
Elisabetta Gabano, Chiara Ferraris, Domenico Osella, Luigi Sebastiano Battaglia, Mauro Ravera
Summary: In this study, lipophilic metal compounds were successfully delivered to cancer cells using Intralipid (R) as a carrier, leading to efficient cell accumulation. Although the use of Intralipid (R) reduced the activity, there is still potential for in vivo application.
INORGANICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Nasimeh Jamgohari, Hassan Mansouri-Torshizi, Effat Dehghanian, Somaye Shahraki, Michal Dusek, Monika Kucerakova
Summary: A new Pd(II) complex and its Pt(II) analogue have been synthesized and characterized. They showed good structural stability in aqueous solution and exhibited cytotoxic activities against cancer cells. Furthermore, they interacted with CT-DNA through groove binding, which was in agreement with experimental results.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Angela Vivancos, Delia Bautista, Pablo Gonzalez-Herrero
Summary: This study reports the synthesis, structure, photophysical properties, and electrochemistry of the first series of Pt(IV) tris-chelates bearing cyclometalated aryl-NHC ligands. The complexes exhibit significant photostability, long-lived phosphorescence, and potential application for Pt(IV) emitters with tunable properties.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Joseph Tadros, Christian Dankers, Ashley Jurisinec, Maria Menti-Platten, Janice R. Aldrich-Wright, Christopher P. Gordon
Summary: A comparative study was conducted on the immobilized triphenylphosphine (PS-PPh3) and 1-hydroxybenzotriazole (PS-HOBt) for mediating amide couplings under continuous flow. The developed 'catch-and-release' approach (PS-HOBt) showed near-quantitative amide conversions, surpassing the Appel-type amidations (PS-PPh3).
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Kieran F. Scott, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Platinum(IV) prodrugs showed outstanding activity against various cancer cell lines, with nanomolar activities observed. Cellular accumulation of the complexes was correlated with increased cytotoxicity. COX inhibition or lipophilicity did not solely determine the cytotoxicity of these prodrugs.
Article
Biochemistry & Molecular Biology
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Summary: The DNA-alkylating derivative chlorambucil was coordinated with atypical cytotoxic platinum(IV) complexes, resulting in prodrugs with remarkable antitumor potential. The prodrug 56CLB showed exceptionally high activity in multiple cancer cell lines and induced significant production of reactive oxygen species in treated cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Jennette Sakoff, Jayne Gilbert, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: This paper describes the development of novel quadruplex DNA-stabilizing metal complexes and demonstrates their stability-enhancing effects on quadruplex DNA. Furthermore, these complexes exhibit cytotoxic effects and show good selectivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Summary: A new series of cytotoxic platinum(IV) complexes incorporating halogenated phenylacetic acid derivatives were synthesized and evaluated for their biological activity. The results showed that two of the complexes exhibited superior cytotoxicity, with one of them being significantly more potent than cisplatin and the lead complex in a prostate cancer cell line. Further studies were conducted to analyze the physicochemical properties and reactive oxygen species production of the complexes.
Article
Chemistry, Medicinal
Aleen Khoury, Elias Elias, Stephanie Mehanna, Wassim Shebaby, Krishant M. Deo, Najwa Mansour, Christian Khalil, Katia Sayyed, Jennette A. Sakoff, Jayne Gilbert, Costantine F. Daher, Christopher P. Gordon, Robin I. Taleb, Janice R. Aldrich-Wright
Summary: A novel platinum(II) complex and its platinum(IV) derivative were synthesized and characterized. Cytotoxicity studies showed that both complexes exhibited 7-20-fold higher activity against cancer cells compared to cisplatin, with the platinum(IV) derivative showing 17-22-fold higher selectivity towards cancer cells compared to non-cancerous cells. Western blot analysis indicated the involvement of the intrinsic apoptotic pathway, and cellular fractionation and uptake experiments demonstrated that the complexes crossed the cellular membrane predominantly via active transport mechanisms. The significant improvement in selectivity exhibited by the platinum(IV) derivative is reported for the first time.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Four platinum(IV) prodrugs incorporating a biotin moiety showed exceptional cytotoxicity against cancer cell lines. One of the prodrugs exhibited the lowest cytotoxicity in prostate cancer cells, while another prodrug showed higher activity in colon cancer cells. Some prodrugs also demonstrated selectivity towards breast cancer cells compared to healthy cells, which was not observed with their platinum(II) precursors.
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Jennette Sakoff, Jayne Gilbert, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Cancer is a significant global health threat and new treatments are needed to improve patient prognosis. Unconventional platinum complexes, consisting of polypyridyl ligands and diaminocyclohexane, have shown anticancer activity in previously undruggable KRAS mutated cells, with cytotoxicity values up to 100 times better than cisplatin. Inspired by these complexes, six novel cyclometallated examples were designed and their fluorescence was used to study the mechanism of action of platinum drugs. The cytotoxicity results showed that these cyclometallated complexes have different activity compared to the inspiring complexes, but are as cytotoxic as cisplatin and have higher selectivity indices in breast cancer cell lines. Complexes 1b, 2a, and 3b exhibited particularly high selectivity indexes. Further investigation revealed their good affinity to ctDNA, especially CMCs 1a and 3b. The fluorescence of these complexes was successfully utilized in calculating their DNA binding affinity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Hana Kostrhunova, Brondwyn S. McGhie, Lenka Markova, Olga Novakova, Jana Kasparkova, Janice R. Aldrich-Wright, Viktor Brabec
Summary: The platinum(II) complex Pt(II)56MeSS exhibits high potency against cancer cells but also displays side toxicity and in vivo activity. The synthesis of new platinum(IV) prodrugs combining Pt(II)56MeSS with diclofenac (DCF) is described. These Pt(IV) complexes show similar mechanisms of action as Pt(II)56MeSS and DCF, promoting antiproliferative activity and inducing cell death and immunogenic cell death in cancer cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Summary: The development of new and versatile platinum(IV) complexes is a rapidly evolving research strategy for cancer drug discovery. In this study, platinum(IV) complexes conjugated with non-steroidal anti-inflammatory molecules were synthesized and showed significantly improved anti-tumor potential compared to traditional platinum(II) chemotherapy drugs. These complexes also demonstrated the ability to reduce cellular and mitochondrial activity, decrease cancer cell resistance to chemotherapy, and inhibit COX-2 enzyme, thereby reducing inflammation in cancer cells.
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)
