标题
Novel therapies emerging in oncology to target the TGF-β pathway
作者
关键词
-
出版物
Journal of Hematology & Oncology
Volume 14, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-04-06
DOI
10.1186/s13045-021-01053-x
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
- (2020) Pierre Fenaux et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial
- (2020) Luis Paz-Ares et al. Journal of Thoracic Oncology
- Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
- (2020) Constance J. Martin et al. Science Translational Medicine
- TGF-β Signaling
- (2020) Kalliopi Tzavlaki et al. Biomolecules
- Clinical development of therapies targeting TGFβ: current knowledge and future perspectives.
- (2020) D. Ciardiello et al. ANNALS OF ONCOLOGY
- 879TiP Phase II study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in platinum-experienced advanced cervical cancer
- (2020) M.J. Birrer et al. ANNALS OF ONCOLOGY
- The role of TGFβ in hematopoiesis and myeloid disorders
- (2019) Alex Bataller et al. LEUKEMIA
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study
- (2019) Su Young Jung et al. INVESTIGATIONAL NEW DRUGS
- Preclinical Studies and Phase I Trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach By Targeting TGF-β Signaling Pathway
- (2019) Ehsan Malek et al. BLOOD
- Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS
- (2019) Srinivas Aluri et al. BLOOD
- Population pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors
- (2019) Su Young Jung et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor
- (2019) Xianguang Bai et al. OncoTargets and Therapy
- c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
- (2019) Wen Jing Sim et al. Nature Communications
- A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment
- (2019) Huynh et al. Biomolecules
- Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
- (2018) Julius Strauss et al. CLINICAL CANCER RESEARCH
- The Balance of Th17 versus Treg Cells in Autoimmunity
- (2018) Gap Lee INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
- A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation
- (2018) Esther N. Arwert et al. Cell Reports
- Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression
- (2018) Jiaqi Tang et al. Cancers
- TGF-β in T Cell Biology: Implications for Cancer Immunotherapy
- (2018) Amina Dahmani et al. Cancers
- TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy
- (2018) Padmini Jayaraman et al. OncoImmunology
- Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation
- (2018) Aoife Kelly et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches
- (2018) Paola Parente et al. Gastroenterology Research and Practice
- TGF-β in pancreatic cancer initiation and progression: two sides of the same coin
- (2017) Wei Shen et al. Cell and Bioscience
- Phase II study of Vigil® DNA engineered immunotherapy as maintenance in advanced stage ovarian cancer
- (2016) Jonathan Oh et al. GYNECOLOGIC ONCOLOGY
- Emerging Frontiers in Drug Delivery
- (2016) Mark W. Tibbitt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Discovery and Early Days of TGF-β: A Historical Perspective
- (2016) Harold L. Moses et al. Cold Spring Harbor Perspectives in Biology
- Transforming Growth Factor-β1 as a Predictor for the Development of Hepatocellular Carcinoma: A Nested Case–Controlled Study
- (2016) Yuko Watanabe et al. EBioMedicine
- Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors
- (2015) Yutaka Fujiwara et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- High Serum Transforming Growth Factor- 1 Levels Predict Outcome in Hepatocellular Carcinoma Patients Treated with Sorafenib
- (2015) T.-H. Lin et al. CLINICAL CANCER RESEARCH
- A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer
- (2015) G. Giaccone et al. EUROPEAN JOURNAL OF CANCER
- Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation
- (2015) Marianna Papaspyridonos et al. Nature Communications
- Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer
- (2015) Kate M. Moore et al. MOLECULAR CANCER RESEARCH
- Tumor-Derived Transforming Growth Factor-β is Critical for Tumor Progression and Evasion from Immune Surveillance
- (2014) Zheng Li et al. Asian Pacific Journal of Cancer Prevention
- An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial–mesenchymal transition
- (2014) Chul-Yong Park et al. CANCER LETTERS
- Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study
- (2014) Richard J. Kovacs et al. Cardiovascular Toxicology
- Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer
- (2014) Jordi Rodón et al. INVESTIGATIONAL NEW DRUGS
- Cutting Edge: Autocrine TGF- Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells
- (2014) M. L. Belladonna et al. JOURNAL OF IMMUNOLOGY
- Discovery of N-((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF-β Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic Agent
- (2014) Cheng Hua Jin et al. JOURNAL OF MEDICINAL CHEMISTRY
- EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis
- (2014) J. Y. Son et al. MOLECULAR CANCER THERAPEUTICS
- Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma
- (2014) John C. Morris et al. PLoS One
- Defining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model
- (2013) Ivelina Gueorguieva et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes
- (2013) Jeong-Hwan Yoon et al. EMBO Molecular Medicine
- Low-dose paclitaxel modulates tumour fibrosis in gastric cancer
- (2013) TOMOYA TSUKADA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- TGF- Signaling in Myeloid Cells Is Required for Tumor Metastasis
- (2013) Y. Pang et al. Cancer Discovery
- TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function
- (2013) Anna Śledzińska et al. PLOS BIOLOGY
- A phase I study of tasisulam sodium (LY573636 sodium), a novel anticancer compound, administered as a 24-h continuous infusion in patients with advanced solid tumors
- (2012) Michael S. Gordon et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Molecular Pathways: Targeting the TGF- Pathway for Cancer Therapy
- (2012) A. L. Smith et al. CLINICAL CANCER RESEARCH
- Gr-1+CD11b+ cells are responsible for tumor promoting effect of TGF-β in breast cancer progression
- (2012) Zhaoyang Li et al. INTERNATIONAL JOURNAL OF CANCER
- Dendritic Cell-Specific Disruption of TGF- Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity
- (2012) R. Ramalingam et al. JOURNAL OF IMMUNOLOGY
- TGFβ signalling in context
- (2012) Joan Massagué NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis and modulates key biomarkers in vivo
- (2012) C Eberlein et al. ONCOGENE
- TGF-beta signalling in colon carcinogenesis
- (2011) Pavlos Lampropoulos et al. CANCER LETTERS
- Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term T RI/II Kinase Inhibition with LY2109761
- (2011) E. C. Connolly et al. CANCER RESEARCH
- The Antisense Oligonucleotide Trabedersen (AP 12009) for the Targeted Inhibition of TGF-β2
- (2011) Frank Jaschinski et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine
- (2011) Moses K. Donkor et al. IMMUNITY
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
- (2011) Maria T Pallotta et al. NATURE IMMUNOLOGY
- TGF- downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients
- (2011) C. A. Crane et al. NEURO-ONCOLOGY
- Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling
- (2011) Youn Sook Lee et al. Nature Communications
- Molecular characterization of TGFβ-induced epithelial-mesenchymal transition in normal finite lifespan human mammary epithelial cells
- (2010) Linsey E. Lindley et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibitory effect of a TGFβ receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells
- (2010) O Shinto et al. BRITISH JOURNAL OF CANCER
- Intravital Imaging Illuminates Transforming Growth Factor β Signaling Switches during Metastasis
- (2010) Silvia Giampieri et al. CANCER RESEARCH
- TGF- -RI Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases
- (2010) K. S. Mohammad et al. CANCER RESEARCH
- Smad2 and Smad3 Are Redundantly Essential for the TGF- -Mediated Regulation of Regulatory T Plasticity and Th1 Development
- (2010) T. Takimoto et al. JOURNAL OF IMMUNOLOGY
- TGF-β Inhibition Restores Terminal Osteoblast Differentiation to Suppress Myeloma Growth
- (2010) Kyoko Takeuchi et al. PLoS One
- TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
- (2010) Li Yang et al. TRENDS IN IMMUNOLOGY
- The regulation of TGF signal transduction
- (2009) A. Moustakas et al. DEVELOPMENT
- Treatment of malignant gliomas with TGF-β2 antisense oligonucleotides
- (2009) Peter Hau et al. Expert Review of Anticancer Therapy
- Human Dendritic Cells Produce TGF- 1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+ Regulatory T Cells
- (2009) I. E. Dumitriu et al. JOURNAL OF IMMUNOLOGY
- An Anti-Transforming Growth Factor Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments
- (2008) J.-S. Nam et al. CANCER RESEARCH
- TGFβ in Cancer
- (2008) Joan Massagué CELL
- Effect of IN-1130, a Small Molecule Inhibitor of Transforming Growth Factor-β Type I Receptor/Activin Receptor-Like Kinase-5, on Prostate Cancer Cells
- (2008) Geun Taek Lee et al. JOURNAL OF UROLOGY
- LY2109761, a novel transforming growth factor receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
- (2008) D. Melisi et al. MOLECULAR CANCER THERAPEUTICS
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