Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production
出版年份 2021 全文链接
标题
Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production
作者
关键词
Astrocytes, -type amino acid transporter 1 (LAT1), Microglia, non-steroidal anti-inflammatory drugs (NSAIDs), Prodrugs, prostaglandin E, 2, (PGE, 2, )
出版物
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 601, Issue -, Pages 120565
出版商
Elsevier BV
发表日期
2021-04-02
DOI
10.1016/j.ijpharm.2021.120565
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Systematic review: ibuprofen-induced liver injury
- (2020) Miguel E. Zoubek et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- L-Type amino acid transporter 1 as a target for drug delivery
- (2020) Elena Puris et al. PHARMACEUTICAL RESEARCH
- Prognostic value of LAT-1 status in solid cancer: A systematic review and meta-analysis
- (2020) Jing-jing Lu et al. PLoS One
- L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels
- (2020) Ahmed Montaser et al. Pharmaceutics
- L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood–Brain Barrier and into Human and Mouse Brain Parenchymal Cells
- (2020) Ahmed B. Montaser et al. ACS Chemical Neuroscience
- L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery
- (2019) Elena Puris et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
- (2019) Pascal Häfliger et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets
- (2019) Elena Puris et al. MOLECULAR PHARMACEUTICS
- L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)
- (2019) Johanna Huttunen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
- (2019) Johanna Huttunen et al. Scientific Reports
- Alzheimer’s Disease Can Be Spared by Nonsteroidal Anti-Inflammatory Drugs
- (2018) Patrick L. McGeer et al. JOURNAL OF ALZHEIMERS DISEASE
- The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
- (2018) Mariafrancesca Scalise et al. Frontiers in Chemistry
- Human carboxylesterases: a comprehensive review
- (2018) Dandan Wang et al. Acta Pharmaceutica Sinica B
- Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen
- (2018) K.M. Huttunen BIOORGANIC CHEMISTRY
- The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics
- (2018) Li Di CURRENT DRUG METABOLISM
- Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
- (2018) Mikko Gynther et al. PHARMACEUTICAL RESEARCH
- L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs
- (2017) Elena Puris et al. JOURNAL OF CONTROLLED RELEASE
- Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer’s Disease
- (2017) Kati-Sisko Vellonen et al. PHARMACEUTICAL RESEARCH
- Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
- (2017) Keitaro Hayashi et al. World Journal of Gastrointestinal Oncology
- Prevention of Renal Complications Induced by Non- Steroidal Anti-Inflammatory Drugs
- (2016) Sonja Vu|kovi| et al. CURRENT MEDICINAL CHEMISTRY
- Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
- (2016) Jeffrey R. Liddell et al. Journal of Neuroinflammation
- Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
- (2016) Mikko Gynther et al. MOLECULAR PHARMACEUTICS
- Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
- (2016) Mikko Gynther et al. NEUROCHEMICAL RESEARCH
- LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells
- (2013) K. Hayashi et al. JOURNAL OF IMMUNOLOGY
- Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine
- (2013) Lauri Peura et al. PHARMACEUTICAL RESEARCH
- The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?
- (2013) S. Casey Laizure et al. PHARMACOTHERAPY
- Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597
- (2012) J. Allen Crow et al. BIOCHEMICAL PHARMACOLOGY
- Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells
- (2008) Akimitsu Maeda et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Protective effects of NSAIDs on the development of Alzheimer disease
- (2008) Steven C. Vlad et al. NEUROLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started