The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?
出版年份 2013 全文链接
标题
The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?
作者
关键词
-
出版物
PHARMACOTHERAPY
Volume 33, Issue 2, Pages 210-222
出版商
Wiley
发表日期
2013-02-05
DOI
10.1002/phar.1194
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Effect of Natural Health Products and Traditional Medicines on the Activity of Human Hepatic Microsomal-Mediated Metabolism of Oseltamivir
- (2016) Rui Liu et al. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
- Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans
- (2012) E K Tarkiainen et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Single-Dose Bioequivalence of 105-mg Fenofibric Acid Tablets Versus 145-mg Fenofibrate Tablets Under Fasting and Fed Conditions: A Report of Two Phase I, Open-Label, Single-Dose, Randomized, Crossover Clinical Trials
- (2011) Anthony R. Godfrey et al. CLINICAL THERAPEUTICS
- Cocaethylene formation following ethanol and cocaine administration by different routes.
- (2011) Ellen D. Herbst et al. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
- Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children
- (2011) Saskia N de Wildt Expert Opinion on Drug Metabolism & Toxicology
- Surge in Expression of Carboxylesterase 1 During the Post-neonatal Stage Enables a Rapid Gain of the Capacity to Activate the Anti-influenza Prodrug Oseltamivir
- (2011) Deshi Shi et al. JOURNAL OF INFECTIOUS DISEASES
- Prediction and In Vitro Evaluation of Selected Protease Inhibitor Antiviral Drugs as Inhibitors of Carboxylesterase 1: A Potential Source of Drug-Drug Interactions
- (2011) Jenna A. Rhoades et al. PHARMACEUTICAL RESEARCH
- Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11
- (2010) M. Jason Hatfield et al. BIOCHEMICAL PHARMACOLOGY
- Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease
- (2010) Fabrizio D'Esposito et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- In Vitro Evaluation of Inhibitory Effects of Antidiabetic and Antihyperlipidemic Drugs on Human Carboxylesterase Activities
- (2010) T. Fukami et al. DRUG METABOLISM AND DISPOSITION
- Involvement of Carboxylesterase 1 and 2 in the Hydrolysis of Mycophenolate Mofetil
- (2010) N. Fujiyama et al. DRUG METABOLISM AND DISPOSITION
- Nuclear receptor-mediated regulation of carboxylesterase expression and activity
- (2010) Jeff L Staudinger et al. Expert Opinion on Drug Metabolism & Toxicology
- A comparison of the metabolism of clopidogrel and prasugrel
- (2010) S Casey Laizure et al. Expert Opinion on Drug Metabolism & Toxicology
- Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine
- (2010) Tomoko Ishizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication
- (2010) David R. Blais et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Homology modeling and metabolism prediction of human carboxylesterase-2 using docking analyses by GriDock: a parallelized tool based on AutoDock 4.0
- (2010) Giulio Vistoli et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
- (2010) Roger S. Holmes et al. MAMMALIAN GENOME
- Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: Potential sources of metabolic drug interactions
- (2010) Hao-Jie Zhu et al. TOXICOLOGY
- Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril
- (2009) Hao-Jie Zhu et al. BIOCHEMICAL PHARMACOLOGY
- Influence of Ionization State on the Activation of Temocapril by hCES1: A Molecular-Dynamics Study
- (2009) Giulio Vistoli et al. CHEMISTRY & BIODIVERSITY
- Different Inhibitory Effects in Rat and Human Carboxylesterases
- (2009) S. Takahashi et al. DRUG METABOLISM AND DISPOSITION
- The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions
- (2009) R. B. Parker et al. DRUG METABOLISM AND DISPOSITION
- Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver
- (2009) H.-J. Zhu et al. DRUG METABOLISM AND DISPOSITION
- Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans
- (2009) Nagy A. Farid et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD
- (2009) Zsofia Nemoda et al. NEUROPHARMACOLOGY
- Human Carboxylesterases: An Update on CES1, CES2 and CES3
- (2009) Sonal P. Sanghani et al. PROTEIN AND PEPTIDE LETTERS
- Two CES1 Gene Mutations Lead to Dysfunctional Carboxylesterase 1 Activity in Man: Clinical Significance and Molecular Basis
- (2008) Hao-Jie Zhu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin
- (2008) Dongfang Yang et al. BIOCHEMICAL PHARMACOLOGY
- Activation of the Antiviral Prodrug Oseltamivir Is Impaired by Two Newly Identified Carboxylesterase 1 Variants
- (2008) H.-J. Zhu et al. DRUG METABOLISM AND DISPOSITION
- The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2
- (2008) E. T. Williams et al. DRUG METABOLISM AND DISPOSITION
- Rufinamide: Clinical pharmacokinetics and concentrationresponse relationships in patients with epilepsy
- (2008) Emilio Perucca et al. EPILEPSIA
- Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs
- (2008) Masakiyo Hosokawa MOLECULES
- Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting
- (2007) Fujun Li et al. JOURNAL OF PHARMACEUTICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now