l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
出版年份 2019 全文链接
标题
l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
作者
关键词
-
出版物
Scientific Reports
Volume 9, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-09-06
DOI
10.1038/s41598-019-49009-z
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery
- (2019) Elena Puris et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Extracellular Prolyl Oligopeptidase Derived from Activated Microglia is a Potential Neuroprotection Target
- (2018) Teemu A. Natunen et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Secondary Carbamate Linker Can Facilitate the Sustained Release of Dopamine from Brain-Targeted Prodrug
- (2018) Nikki A. Thiele et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen
- (2018) K.M. Huttunen BIOORGANIC CHEMISTRY
- Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
- (2018) Mikko Gynther et al. PHARMACEUTICAL RESEARCH
- Effects of nonsteroidal anti-inflammatory drugs on the renal excretion of indoxyl sulfate, a nephro-cardiovascular toxin, in rats
- (2017) Chung-Ping Yu et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs
- (2017) Elena Puris et al. JOURNAL OF CONTROLLED RELEASE
- Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist
- (2017) Mikko Gynther et al. JOURNAL OF MEDICINAL CHEMISTRY
- Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer’s Disease
- (2017) Kati-Sisko Vellonen et al. PHARMACEUTICAL RESEARCH
- l -Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors
- (2016) Kristiina M. Huttunen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Glucose Transporters in Brain: In Health and in Alzheimer’s Disease
- (2016) Leszek Szablewski JOURNAL OF ALZHEIMERS DISEASE
- A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells
- (2016) Kristiina M. Huttunen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
- (2016) Jeffrey R. Liddell et al. Journal of Neuroinflammation
- Perforin Promotes Amyloid Beta Internalisation in Neurons
- (2016) Erica Lana et al. MOLECULAR NEUROBIOLOGY
- Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
- (2016) Mikko Gynther et al. MOLECULAR PHARMACEUTICS
- Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
- (2016) Mikko Gynther et al. NEUROCHEMICAL RESEARCH
- The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation
- (2016) Anja Henn ALTEX-Alternatives to Animal Experimentation
- Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
- (2015) Utpal Das et al. NATURE NEUROSCIENCE
- Two decades of new drug development for central nervous system disorders
- (2015) Aaron S. Kesselheim et al. NATURE REVIEWS DRUG DISCOVERY
- Improving and Accelerating Drug Development for Nervous System Disorders
- (2014) Diana E. Pankevich et al. NEURON
- Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine
- (2013) Lauri Peura et al. PHARMACEUTICAL RESEARCH
- Ferulic Acid Is a Nutraceutical β-Secretase Modulator That Improves Behavioral Impairment and Alzheimer-like Pathology in Transgenic Mice
- (2013) Takashi Mori et al. PLoS One
- Drug Transport across the Blood–Brain Barrier
- (2012) William M Pardridge JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease
- (2012) Branden Stansley et al. Journal of Neuroinflammation
- Characterization of the carrier-mediated transport of ketoprofen, a nonsteroidal anti-inflammatory drug, in rabbit corneal epithelium cells
- (2012) Shinobu Fujii et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only
- (2011) Douglas B. Kell et al. DRUG DISCOVERY TODAY
- Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
- (2011) Yasuo Uchida et al. JOURNAL OF NEUROCHEMISTRY
- Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery
- (2011) Lauri Peura et al. MOLECULAR PHARMACEUTICS
- Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells
- (2010) Doreen Braun et al. GLIA
- Brain uptake of ketoprofen–lysine prodrug in rats
- (2010) Mikko Gynther et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Cytotoxic CD8+ T Cell-Neuron Interactions: Perforin-Dependent Electrical Silencing Precedes But Is Not Causally Linked to Neuronal Cell Death
- (2009) S. G. Meuth et al. JOURNAL OF NEUROSCIENCE
- Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells)
- (2009) Atsushi Yamamoto et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
- (2009) Dan Zhang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs
- (2008) Mikko Gynther et al. JOURNAL OF MEDICINAL CHEMISTRY
- Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
- (2008) Paul D. Dobson et al. NATURE REVIEWS DRUG DISCOVERY
- The adult human brain in preclinical drug development
- (2008) Mike Dragunow NATURE REVIEWS DRUG DISCOVERY
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