Article
Chemistry, Multidisciplinary
Mosleh Mohammad Abomughaid
Summary: Silica nanoparticles with good antioxidant activity were synthesized using the aqueous extract of orange peels by a green chemistry approach.
Article
Biochemistry & Molecular Biology
Lucia Castro-Vazquez, Maria Victoria Lozano, Virginia Rodriguez-Robledo, Joaquin Gonzalez-Fuentes, Pilar Marcos, Noemi Villaseca, Maria Mar Arroyo-Jimenez, Manuel J. Santander-Ortega
Summary: Research found that freeze-dried Sanguina orange peel showed the highest antioxidant potential, with significantly higher levels of total polyphenols and flavonoids compared to other varieties and drying methods. This suggests that freeze-dried orange peel can be a good source of natural antioxidants for the development of new products with commercial interest in food applications.
Article
Biochemistry & Molecular Biology
Xiaoxi Liao, Phillip Greenspan, Ronald B. Pegg
Summary: This study used acidified aqueous methanol and acidified aqueous acetone as extraction solvents for blackberry phenolics, comparing the antioxidant properties of the extracts. Methanol was more efficient at extracting anthocyanins and flavonols, while acetone was better at extracting flavan-3-ols and tannins. Overall, the acetonic solvent system showed superior antioxidant capacity, with flavan-3-ols and ellagitannins potentially accounting for the observed differences in antioxidant activity between the two solvent systems.
Article
Chemistry, Analytical
C. Espro, A. Satira, F. Mauriello, Z. Anajafi, K. Moulaee, D. Iannazzo, G. Neri
Summary: Hydrochar samples were prepared from orange peels waste via hydrothermal carbonization at different temperatures, showing different morphological and microstructural characteristics. The hydrochar demonstrated potential for use in high-performance chemical sensors, especially the HC300 sample. The HC300-based sensors showed sensitivity to detect NO2 and dopamine with impressive performance characteristics.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Medicinal
Yue Sui, Yue Gu, Yujing Lu, Chenxu Yu, Jie Zheng, Hang Qi
Summary: By encapsulating FX in PVP-coated nanoparticles, the study improved FX stability and delivery into cancer cells, showing pro-oxidative activities. This approach could potentially be a new therapeutic strategy for targeted cancer treatment.
Article
Food Science & Technology
Divyani Panwar, Parmjit S. Panesar, Harish K. Chopra
Summary: The aim of this work was to study the composition, properties, and potential food applications of C. limetta peels. The peels were found to have a high content of ash, crude fiber, carbohydrate, protein, potassium, calcium, magnesium, asparagine, glutamic acid, and aspartic acid. They also exhibited high levels of dietary fiber, phenolic content, and antioxidant activity. The peels showed potential as emulsifying, gelling, foaming, and bulking agents in the food industry. Therefore, they can be re-utilized as a natural food additive with various nutritive and bioactive properties, contributing to zero waste generation.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Food Science & Technology
Emine Okumus, Emre Bakkalbasi
Summary: The study found that pomegranate peels are rich in polyphenols and antioxidants, and exhibit antidiabetic activity, with high bioaccessibility after in vitro digestion. Pomegranate peel could be a natural source for potential applications in the pharmaceutical, food, and cosmetics industries.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2021)
Article
Food Science & Technology
Juliana Santos de Espindola, Milena Ferreira Taccola, Vera Sonia Nunes da Silva, Lucilene Delazari dos Santos, Bruno Cesar Rossini, Bruna Cavecci Mendonca, Maria Teresa Bertoldo Pacheco, Fabiana Galland
Summary: During digestion in the gastrointestinal tract, whey peptides are formed and exhibit antioxidant activity, protecting the gastrointestinal cells from oxidative damage. These peptides contain hydrophobic and acidic amino acids, with lysine, valine, and tyrosine being the most abundant, which have antioxidant properties. The antioxidant activity of these peptides was found to be twice as potent as that of protein isolates at the same concentration. This study highlights the importance of whey peptides in preventing oxidative stress in the digestive system.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Afshin Selahvarzi, Yousef Ramezan, Mohammad Reza Sanjabi, Bahareh Namdar, Marjan Akbarmivehie, Hossein Mirsaeedghazi, Fatemeh Azarikia
Summary: This study optimized the ultrasound extraction conditions of phenolic compounds from pomegranate and orange peels and used the extracts to enrich a functional drink. The results showed that the extraction time, temperature, and solid to solvent ratio had significant effects on the total phenol content and antioxidant activity. Adding the extracts to the drinks significantly enhanced the bioactive compounds content and antioxidant activity. However, during cold storage, the content of bioactive compounds and antioxidant activity gradually decreased.
Article
Chemistry, Applied
Shirley L. Sampaio, Spyridon A. Petropoulos, Maria Ines Dias, Carla Pereira, Ricardo C. Calhelha, Angela Fernandes, Camila M. M. Leme, Alexios Alexopoulos, Celestino Santos-Buelga, Isabel C. F. R. Ferreira, Lillian Barros
Summary: This study provides a detailed analysis of non-anthocyanin and anthocyanin phenolic compounds in potato peels from ten colored potato varieties, as well as a comprehensive evaluation of their antioxidant, cytotoxic, and anti-inflammatory potentials. The findings indicate that caffeic acid and caffeoylquinic acid were the most abundant non-anthocyanin phenolics in all samples, along with the presence of O-glycosylated flavonol derivatives and polyamine derivatives. Additionally, acylated anthocyanins were identified in red and purple varieties, with pelargonidin, peonidin, and malvidin being the most prominent aglycones detected. All samples demonstrated antioxidant and antitumor activities, with no observed toxicity, while the Rosemary variety exhibited the highest antioxidant and antitumor effects and was the only sample to show anti-inflammatory activity. These results have significant implications for the food industry in terms of utilizing potato peel as a natural ingredient in novel food and pharmaceutical formulations.
Article
Food Science & Technology
Mohamed G. Shehata, Nourhan M. Abd El Aziz, Mohamed M. Youssef, Sobhy A. El-Sohaimy
Summary: This study optimized the extraction conditions of bioactive compounds from orange peels using response surface methodology (RSM), focusing on factors such as extraction temperature and ethanol concentration. The optimal conditions were found to be 44 min extraction time, 50 degrees Celsius extraction temperature, and 57.7% ethanol concentration, resulting in high yields of total phenolic and flavonoid contents. RSM was effective in saving extraction time and improving efficiency.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Biotechnology & Applied Microbiology
Rafael G. Araujo, Rosa M. Rodriguez-Jasso, Hector A. Ruiz, Mayela Govea-Salas, Manuela Pintado, Cristobal N. Aguilar
Summary: This study aimed to explore the unexplored high value-added antioxidant compounds in avocado peels and found that the optimal conditions for obtaining the highest antioxidant capacity were achieved with 42.58% ethanol concentration through the optimization of microwave-assisted extraction.
FOOD AND BIOPRODUCTS PROCESSING
(2021)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Acoustics
N. A. Patience, D. Schieppati, D. C. Boffito
Summary: This study utilized ultrasound technology to extract pectin from waste orange peels. The results showed that increasing amplitude/power density and decreasing pH can improve the extraction yield of pectin. There was no significant difference in yield between continuous ultrasound and pulse ultrasound modes under the same conditions, but pulse mode consumed less energy.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Yuhuan Chen, Hua Zhang, Wenyi Fan, Lili Mats, Ronghua Liu, Zeyuan Deng, Rong Tsao
Summary: The phenolic compounds derived from common beans can be metabolized and absorbed by intestinal epithelial cells, exhibiting antioxidant and anti-inflammatory effects against oxidative stress injury in vascular endothelial cells, thereby contributing to the amelioration of vascular diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ayokunle O. Ademosun, Adeniyi A. Adebayo, Temitope Popoola, Ganiyu Oboh
Summary: This study investigated the effect of shaddock peels extract on cognitive function in scopolamine-induced amnesic rats. The results showed that shaddock peels extract reversed the memory and cognitive impairment caused by scopolamine, possibly through its antioxidant activities and modulation of enzyme activities.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Adedayo Oluwaseun Ademiluyi, Opeyemi Babatunde Ogunsuyi, Josephine Oluwaseun Akinduro, Olayemi Philemon Aro, Ganiyu Oboh
Summary: The protective effect of alkaloid extracts from Scent leaf and Water bitter leaf on manganese-induced toxicity in fruit fly model was investigated. Results showed that the extracts reversed manganese-induced reduction in the survival rate and locomotor performance of the flies, as well as restored antioxidant enzyme activities.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Plant Sciences
Oluwakemi Adeleke, Ganiyu Oboh, Stephen Adefegha, Adebayo Osesusi
Summary: This study demonstrated that the aqueous extracts of Sphenocentrum jollyanum root and leaf can enhance wound healing in diabetic rats by modulating pro-inflammatory cytokines, vascular endothelial growth factor, and microbial colonization.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Opeyemi Oluwafemi Ojueromi, Ganiyu Oboh, Ayokunle Olubode Ademosun
Summary: The study demonstrates the potential of black seed as a dietary supplement in improving inflammatory and immune response in mice infected with malaria. It shows that black seed can enhance antioxidant status, modulate inflammatory cytokines, and improve immunomodulatory mediators.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Opeyemi B. Ogunsuyi, Folorunsho B. Omage, Omamuyovwi M. Ijomone, Ganiyu Oboh, Joao B. T. Rocha
Summary: The study investigated the impact of chlorogenic acid on the therapeutic properties of donepezil in a rat model of amnesia induced by scopolamine. The results showed that chlorogenic acid improved the impaired biochemical parameters, glial cells, and neuronal function in scopolamine-treated rats. Docking analysis also revealed a higher binding energy between donepezil and chlorogenic acid with acetylcholinesterase and butyrylcholinesterase compared to individual interactions. This study suggests that chlorogenic acid could enhance the therapeutic effects of donepezil.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Opeyemi Babatunde Ogunsuyi, Olayemi Philemon Aro, Ganiyu Oboh, Olawande Chinedu Olagoke
Summary: This study evaluated the impact of curcumin on the therapeutic effects of donepezil in Alzheimer's disease, and found that the combination of curcumin and donepezil can significantly improve memory impairment and biochemical parameters.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Opeyemi Babatunde Ogunsuyi, Folorunsho Bright Omage, Olawande Chinedu Olagoke, Ganiyu Oboh, Joao Batista Teixeria Rocha
Summary: This study tested the inhibitory effects of African eggplant and black nightshade leaf extracts on human erythrocyte AChE and investigated their potential molecular mechanisms using molecular docking and MD simulation. The findings suggest that certain compounds with dual-binding properties may serve as potential inhibitors of human AChE.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Sunday Oyeleye, Adedayo O. Ademiluyi, Ojo O. Raymond, Ganiyu Oboh
Summary: The combination of ML/MS supplemented diets and ACA synergistically modulates the tested biochemicals, improving antioxidant status and suppressing diabetic cardiomyopathy markers in rats. Further research is needed to confirm the effects on blood vessels, nerves, LV hypertrophy, fibrosis, gene expression, and clinical trials.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Andrology
Stephen Adeniyi Adefegha, Ganiyu Oboh, Abraham Olanrewaju Adedipe
Summary: The aqueous extract of Massularia acuminata stem (MAS) has been found to be effective in treating erectile dysfunction (ED), with its action being attributed to the modulation of sexual behavior, hormonal levels, enzyme activity, and related molecular levels. Additionally, phenolic compounds such as catechin and kaempferol have been identified as the main bioactive compounds in MAS, which may contribute to its erectogenic effects.
Article
Biotechnology & Applied Microbiology
Adeniyi A. Adebayo, Ayokunle O. Ademosun, Bukola C. Adedayo, Ganiyu Oboh
Summary: This study aimed to investigate the effects of Terminalia catappa fruits on blood pressure, NO/cGMP signalling pathway, angiotensin-1-converting enzyme and arginase activity, and oxidative stress biomarkers in hypertensive rats induced by L-NAME. The results showed that L-NAME caused an increase in blood pressure and enzyme activity, as well as oxidative stress, but treatment with Terminalia catappa fruits and sildenafil citrate lowered blood pressure and improved antioxidant status. Therefore, Terminalia catappa fruits could be considered as a dietary regimen and functional food in alleviating hypertension.
Article
Biochemistry & Molecular Biology
Antonella Bandiera, Laura Colomina-Alfaro, Paola Sist, Giovanna Gomez d'Ayala, Federica Zuppardi, Pierfrancesco Cerruti, Ovidio Catanzano, Sabina Passamonti, Ranieri Urbani
Summary: Genetic engineering allows for precise control and manipulation of protein properties, enabling the development of novel materials and systems with enhanced interactive capabilities with biological systems. Elastin-like polypeptides are customizable recombinant biopolymers that have been shown to effectively interact with biological systems. The biomimetic approach for designing elastin-based recombinant polypeptides offers a versatile and valuable tool for creating protein-based materials with improved properties and advanced functionality.
Article
Biochemistry & Molecular Biology
Paola Sist, Federica Tramer, Antonella Bandiera, Ranieri Urbani, Sara Redensek Trampuz, Vita Dolzan, Sabina Passamonti
Summary: A versatile fluorometric method for nanoscale analysis of bilirubin was developed, allowing sensitive and accurate measurement in small animals and human plasma. The method is highly specific and robust, and can detect differences in bilirubin levels related to sex and genetic polymorphisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonella Bandiera, Laura Colomina-Alfaro, Paola Sist, Giovanna Gomez d'Ayala, Federica Zuppardi, Pierfrancesco Cerruti, Ovidio Catanzano, Sabina Passamonti, Ranieri Urbani
Summary: Genetic engineering allows the creation of new materials and systems with improved capacity to interact with biological systems by manipulating protein properties. Elastin-like polypeptides are tunable recombinant biopolymers that can interact with biological systems due to their thermoresponsive behavior. The biomimetic strategy adopted in the design of new elastin-based recombinant polypeptides is a versatile and valuable tool for developing protein-based materials with improved properties and advanced functionality.
Article
Food Science & Technology
Olufunke Florence Ajeigbe, Ganiyu Oboh, Ayokunle Olubode Ademosun, Ademola Adetokunbo Oyagbemi
Summary: Dietary sources such as sandpaper leaves have shown potential in managing hypertension and hyperlipidemia. A study conducted on hypertensive rats found that biscuits supplemented with Ficus asperifolia (FA) extracts significantly reduced blood pressure and improved lipid profile. The study also revealed the antioxidant potential of FA in the heart and lungs of hypertensive rats.
Article
Food Science & Technology
Ganiyu Oboh, Gbemisola Margaret Busari, Ayokunle Olubode Ademosun, Sunday Idowu Oyeleye
Summary: This study evaluated the effects of dietary supplementation with fireweed leaf on neurodegenerative markers in a fruit fly model of Alzheimer's disease. The results showed that fireweed leaf treatment improved survival rate and behavioral performance, inhibited cholinesterase and monoamine oxidase activities, and enhanced antioxidant status in the fruit flies. These effects may be attributed to the polyphenols and dietary fibers present in fireweed leaf. The findings suggest that fireweed leaf may have neuroprotective properties and support its traditional use for the management of neurological disorders.
