Inflammation, immunity and potential target therapy of SARS-COV-2: A total scale analysis review

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2

(2020) Zhixin Liu et al.   JOURNAL OF MEDICAL VIROLOGY

Potential interventions for novel coronavirus in China: A systematic review

(2020) Lei Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

(2020) Clark D Russell et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

COVID-19: combining antiviral and anti-inflammatory treatments

(2020) Justin Stebbing et al.   LANCET INFECTIOUS DISEASES

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

(2020) Jesús Villar et al.   Lancet Respiratory Medicine

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19

(2020) Libo Zhang et al.   Aging-US

Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China

(2020) Lei Pan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series

(2020) Achille Aouba et al.   ANNALS OF THE RHEUMATIC DISEASES

Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy

(2020) Paola Toniati et al.   AUTOIMMUNITY REVIEWS

Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis

(2020) Zhikang Ye et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

(2020) Liang Chen et al.   CARDIOVASCULAR RESEARCH

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19 infection: the perspectives on immune responses

(2020) Yufang Shi et al.   CELL DEATH AND DIFFERENTIATION

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

(2020) George Dimopoulos et al.   Cell Host & Microbe

Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

(2020) Bin Zhang et al.   CHEST

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China

(2020) Wen Zhang et al.   CLINICAL IMMUNOLOGY

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

(2020) Mehmet Soy et al.   CLINICAL RHEUMATOLOGY

Non‐complicated evolution of COVID ‐19 infection in a patient with psoriasis and psoriatic arthritis during treatment with adalimumab

(2020) M. Valenti et al.   Dermatologic Therapy

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

COVID-19: Top 60 Drug Treatments in Development

(2020) Alex Philippidis   Genetic Engineering & Biotechnology News

Covid-19 infection in Crohn’s disease under treatment with adalimumab

(2020) Antonio Tursi et al.   GUT

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial

(2020) Yang Cao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Successful use of methylprednisolone for treating severe COVID-19

(2020) Jing Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Safety and efficacy of early high-dose IV anakinra in severe COVID-19 lung disease

(2020) Emanuele Pontali et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The convalescent sera option for containing COVID-19

(2020) Arturo Casadevall et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2: a storm is raging

(2020) Savannah F. Pedersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COVID-19 illness in native and immunosuppressed states: A clinical–therapeutic staging proposal

(2020) Hasan K. Siddiqi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in Patients With Coronavirus Disease 2019

(2020) Qing-Lei Zeng et al.   JOURNAL OF INFECTIOUS DISEASES

Tocilizumab treatment in COVID-19: A single center experience

(2020) Pan Luo et al.   JOURNAL OF MEDICAL VIROLOGY

Baricitinib: a chance to treat COVID‐19?

(2020) S Lo Caputo et al.   JOURNAL OF MEDICAL VIROLOGY

Effects of methylprednisolone use on viral genomic nucleic acid negative conversion and CT imaging lesion absorption in COVID‐19 patients under 50 years old

(2020) Yuan Gong et al.   JOURNAL OF MEDICAL VIROLOGY

Treatment with convalescent plasma for COVID-19 patients in Wuhan, China

(2020) Mingxiang Ye et al.   JOURNAL OF MEDICAL VIROLOGY

COVID‐19 pneumonia treated with Sarilumab: a clinical series of eight patients

(2020) Maurizio Benucci et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Convalescent plasma for patients with COVID-19

(2020) Furong Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why the immune system fails to mount an adaptive immune response to a COVID‐19 infection

(2020) Pedram Ahmadpoor et al.   TRANSPLANT INTERNATIONAL

Drug treatment options for the 2019-new coronavirus (2019-nCoV)

(2020) Hongzhou Lu   BioScience Trends

Covid-19: FDA approves use of convalescent plasma to treat critically ill patients

(2020) Janice Hopkins Tanne   BMJ-British Medical Journal

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far

(2020) Firas A. Rabi et al.   Pathogens

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

(2020) Sara Mastaglio et al.   CLINICAL IMMUNOLOGY

Subcutaneous administration of interferon beta-1a for COVID-19: A non-controlled prospective trial

(2020) Farzaneh Dastan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

(2020) Ling Li et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up

(2020) Lang Wang et al.   JOURNAL OF INFECTION

The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation

(2020) F. La Rosée et al.   LEUKEMIA

COVID-19: Melatonin as a potential adjuvant treatment

(2020) Rui Zhang et al.   LIFE SCIENCES

Ongoing Clinical Trials for the Management of the COVID-19 Pandemic

(2020) Mark P. Lythgoe et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effectiveness of Interferon Beta 1a, compared to Interferon Beta 1b and the usual therapeutic regimen to treat adults with moderate to severe COVID-19: structured summary of a study protocol for a randomized controlled trial

(2020) Seyed Sina Naghibi Irvani et al.   Trials

The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

(2020) Hussin A. Rothan et al.   VIROLOGY

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

(2020) Muhammad Adnan Shereen et al.   Journal of Advanced Research

Cytokine storm induced by SARS-CoV-2

(2020) Peipei Song et al.   CLINICA CHIMICA ACTA

Decreased T cell populations contribute to the increased severity of COVID-19

(2020) Rui Liu et al.   CLINICA CHIMICA ACTA

Imatinib for COVID-19: A case report

(2020) Alejandro Morales-Ortega et al.   CLINICAL IMMUNOLOGY

Why choose cyclosporin A as first-line therapy in COVID-19 pneumonia

(2020) Olga Sanchez-Pernaute et al.   Reumatologia Clinica

Emapalumab: First Global Approval

(2019) Zaina T. Al-Salama   DRUGS

Ravulizumab: First Global Approval

(2019) Kate McKeage   DRUGS

Eficacia de tofacitinib en el tratamiento de la colitis ulcerosa

(2019) Julián Panés et al.   Gastroenterologia y Hepatologia

Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib

(2019) Elena Maria Elli et al.   Frontiers in Oncology

Towards the Application of Human Defensins as Antivirals

(2018) Mee Sook Park et al.   Biomolecules & Therapeutics

Simultaneous presence of hypercoagulation and increased clot lysis time due to IL-1β, IL-6 and IL-8

(2018) Janette Bester et al.   CYTOKINE

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient

(2018) Peihua Niu et al.   JOURNAL OF INFECTIOUS DISEASES

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

(2018) Aran Singanayagam et al.   Nature Communications

Serum thymosin alpha 1 levels in normal and pathological conditions

(2018) Francesca Pica et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution

(2018) Lei Yan et al.   Acta Crystallographica Section D-Structural Biology

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Antibody-dependent enhancement of severe dengue disease in humans

(2017) Leah C. Katzelnick et al.   SCIENCE

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure ProgressionNovelty and Significance

(2016) Huan Wang et al.   HYPERTENSION

A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems

(2016) Ivan Lebedev et al.   JOURNAL OF MOLECULAR BIOLOGY

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion

(2016) Christopher M. Coleman et al.   JOURNAL OF VIROLOGY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea

(2016) Johan van Griensven et al.   NEW ENGLAND JOURNAL OF MEDICINE

Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

(2016) Md. Mostafizur Rahman et al.   Scientific Reports

Stratification of responders towards eculizumab using a structural epitope mapping strategy

(2016) Anna-Luisa Volk et al.   Scientific Reports

Adrenal Insufficiency in Corticosteroids Use: Systematic Review and Meta-Analysis

(2015) Leonie H. A. Broersen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NK cells inhibit humoral immunity by reducing the abundance of CD4+ T follicular helper cells during a chronic virus infection

(2015) Kevin D. Cook et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ebola virus: Melatonin as a readily available treatment option

(2015) George Anderson et al.   JOURNAL OF MEDICAL VIROLOGY

Tranilast: A review of its therapeutic applications

(2015) Sara Darakhshan et al.   PHARMACOLOGICAL RESEARCH

T cell exhaustion during persistent viral infections

(2015) Shannon M. Kahan et al.   VIROLOGY

Clinical Development of Siltuximab

(2015) Christine C. Davis et al.   Current Oncology Reports

Immunological Consequences of JAK Inhibition: Friend or Foe?

(2015) Donal P. McLornan et al.   Current Hematologic Malignancy Reports

Systemic cyclosporine and corneal transplantation

(2015) Mohammed Ziaei et al.   INTERNATIONAL OPHTHALMOLOGY

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment With Anti-C5a Antibody Improves the Outcome of H7N9 Virus Infection in African Green Monkeys

(2014) Shihui Sun et al.   CLINICAL INFECTIOUS DISEASES

Nivolumab: A Review of Its Use in Patients with Malignant Melanoma

(2014) Emma D. Deeks   DRUGS

Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice

(2014) Haiyan Zhu et al.   INFLAMMATION

Therapeutic Role of Anakinra, an Interleukin-1 Receptor Antagonist, in the Management of Secondary Hemophagocytic Lymphohistiocytosis/Sepsis/Multiple Organ Dysfunction/Macrophage Activating Syndrome in Critically Ill Children*

(2014) Surender Rajasekaran et al.   Pediatric Critical Care Medicine

Pharmacologic Blockade of JAK1/JAK2 Reduces GvHD and Preserves the Graft-Versus-Leukemia Effect

(2014) Jaebok Choi et al.   PLoS One

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Delineation of Interfaces on Human Alpha-Defensins Critical for Human Adenovirus and Human Papillomavirus Inhibition

(2014) Victoria R. Tenge et al.   PLoS Pathogens

Coronavirus infection, ER stress, apoptosis and innate immunity

(2014) To S. Fung et al.   Frontiers in Microbiology

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

(2014) Jennifer Kouznetsova et al.   Emerging Microbes & Infections

Thalidomide–A Notorious Sedative to a Wonder Anticancer Drug

(2013) Shuang Zhou et al.   CURRENT MEDICINAL CHEMISTRY

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

(2013) Erin E. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors

(2012) Anna Yarilina et al.   ARTHRITIS AND RHEUMATISM

P156 Investigating the novel mechanism of action for NI-0501, a human interferon gamma monoclonal antibody

(2012) E. Hatterer et al.   CYTOKINE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

(2012) Carolien E. van de Sandt et al.   Viruses-Basel

Injection-site reactions upon Kineret (anakinra) administration: experiences and explanations

(2011) Christina Kaiser et al.   RHEUMATOLOGY INTERNATIONAL

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

(2010) Debra M Meyer et al.   Journal of Inflammation-London

Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway

(2010) I.-Y. Chen et al.   JOURNAL OF VIROLOGY

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

(2010) Ali Danesh et al.   VIROLOGY

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

(2010) Matthew B. Frieman et al.   PLoS Pathogens

Current status and challenges of cytokine pharmacology

(2009) Z Zídek et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells

(2009) Simona Bancos et al.   CELLULAR IMMUNOLOGY

Cutting Edge: IL-2 Immune Complexes As a Therapy for Persistent Virus Infection

(2009) M. J. Molloy et al.   JOURNAL OF IMMUNOLOGY

CCR5 Deletion Protects Against Inflammation-Associated Mortality in Dialysis Patients

(2009) F. L.H. Muntinghe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

IL-6 predicts organ dysfunction and mortality in patients with multiple injuries

(2009) Michael Frink et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice

(2008) Noriyo Nagata et al.   AMERICAN JOURNAL OF PATHOLOGY

Auranofin inhibits overproduction of pro-inflammatory cytokines, cyclooxygenase expression and PGE2 production in macrophages

(2008) Shinha Han et al.   ARCHIVES OF PHARMACAL RESEARCH

Tranilast, an orally active anti-allergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but down-regulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages

(2008) Hyun-Ock Pae et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of murine dendritic cell function by adenine nucleotides and adenosine: Involvement of the A2B receptor

(2008) Abduelhakem Ben Addi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY