Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state

(2015) Felipe Andrade   IMMUNOLOGICAL REVIEWS

CD4+ and CD8+ T Cells Exhibit Differential Requirements for CCR7-Mediated Antigen Transport during Influenza Infection

(2014) A. K. Heer et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway

(2014) J. Pothlichet et al.   JOURNAL OF IMMUNOLOGY

A Novel Role for Non-Neutralizing Antibodies against Nucleoprotein in Facilitating Resistance to Influenza Virus

(2014) D. M. Carragher et al.   JOURNAL OF IMMUNOLOGY

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

(2014) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults

(2012) Saranya Sridhar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Use of influenza A viruses expressing reporter genes to assess the frequency of double infections in vitro

(2012) R. Bodewes et al.   JOURNAL OF GENERAL VIROLOGY

The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells

(2012) Andrea Rückle et al.   JOURNAL OF VIROLOGY

NS1-Truncated Live Attenuated Virus Vaccine Provides Robust Protection to Aged Mice from Viral Challenge

(2012) N. Pica et al.   JOURNAL OF VIROLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Sublingual Immunization with a Live Attenuated Influenza A Virus Lacking the Nonstructural Protein 1 Induces Broad Protective Immunity in Mice

(2012) Hae-Jung Park et al.   PLoS One

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis

(2012) T. T. Wang et al.   SCIENCE

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

The Potential for Respiratory Droplet-Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host

(2012) C. A. Russell et al.   SCIENCE

Quail as a potential mixing vessel for the generation of new reassortant influenza A viruses

(2012) Aunyaratana Thontiravong et al.   VETERINARY MICROBIOLOGY

Structural basis of influenza virus neutralization

(2011) Thomas Han et al.   Annals of the New York Academy of Sciences

The influenza virus PB1-F2 protein has interferon antagonistic activity

(2011) Sabine E. Dudek et al.   BIOLOGICAL CHEMISTRY

Prevalence of Antibodies against Seasonal Influenza A and B Viruses in Children in Netherlands

(2011) R. Bodewes et al.   Clinical and Vaccine Immunology

Pre-pandemic and pandemic influenza vaccines

(2011) Steven Rockman et al.   Human vaccines & immunotherapeutics

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants

(2011) Klaas P.J.M. van Gisbergen et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

CD4+ T helper 2 cells - microbial triggers, differentiation requirements and effector functions

(2011) Isobel S. Okoye et al.   IMMUNOLOGY

Stalk Domain of the Dynamin-like MxA GTPase Protein Mediates Membrane Binding and Liposome Tubulation via the Unstructured L4 Loop

(2011) Alexander von der Malsburg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines

(2011) Marine L. B. Hillaire et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

(2011) M. L. B. Hillaire et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Mutations in a Dominant Nef Epitope of Simian Immunodeficiency Virus Diminish TCR:Epitope Peptide Affinity but not Epitope Peptide:MHC Class I Binding

(2011) E. M. Cale et al.   JOURNAL OF IMMUNOLOGY

Protective B Cell Responses to Flu—No Fluke!

(2011) Elizabeth E. Waffarn et al.   JOURNAL OF IMMUNOLOGY

Serological Memory and Long-term Protection to Novel H1N1 Influenza Virus After Skin Vaccination

(2011) Dimitrios G. Koutsonanos et al.   JOURNAL OF INFECTIOUS DISEASES

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Hallmarks of CD4 T cell immunity against influenza

(2011) K. K. McKinstry et al.   JOURNAL OF INTERNAL MEDICINE

Regulation of Antinucleoprotein IgG by Systemic Vaccination and Its Effect on Influenza Virus Clearance

(2011) M. W. LaMere et al.   JOURNAL OF VIROLOGY

Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8+ T Cell Immunity in Children

(2011) R. Bodewes et al.   JOURNAL OF VIROLOGY

Vaccination against Seasonal Influenza A/H3N2 Virus Reduces the Induction of Heterosubtypic Immunity against Influenza A/H5N1 Virus Infection in Ferrets

(2011) R. Bodewes et al.   JOURNAL OF VIROLOGY

Budding Capability of the Influenza Virus Neuraminidase Can Be Modulated by Tetherin

(2011) M. A. Yondola et al.   JOURNAL OF VIROLOGY

Overview/reflections on the 2009 H1N1 pandemic

(2011) Surinder Pada et al.   MICROBES AND INFECTION

Influenza Virus-Like Particles Containing M2 Induce Broadly Cross Protective Immunity

(2011) Jae-Min Song et al.   PLoS One

Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation

(2011) Kulbhushan Sharma et al.   PLoS One

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Live attenuated pandemic influenza vaccine: Clinical studies on A/17/California/2009/38 (H1N1) and licensing of the Russian-developed technology to WHO for pandemic influenza preparedness in developing countries

(2011) Larisa Rudenko et al.   VACCINE

Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin

(2011) Rie Watanabe et al.   VIROLOGY

Predicting ‘airborne’ influenza viruses: (trans-) mission impossible?

(2011) EM Sorrell et al.   Current Opinion in Virology

Highly Pathogenic Avian Influenza Virus H5N1 Infects Alveolar Macrophages without Virus Production or Excessive TNF-Alpha Induction

(2011) Debby van Riel et al.   PLoS Pathogens

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

Respiratory epithelial cells in innate immunity to influenza virus infection

(2010) Catherine J. Sanders et al.   CELL AND TISSUE RESEARCH

Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1

(2010) T. K. Berthoud et al.   CLINICAL INFECTIOUS DISEASES

Viral evasion of T cell immunity: ancient mechanisms offering new applications

(2010) Daniëlle Horst et al.   CURRENT OPINION IN IMMUNOLOGY

Vaccination strategies and vaccine formulations for epidemic and pandemic influenza control

(2010) Joost H.C.M. Kreijtz et al.   Human vaccines & immunotherapeutics

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

Transplacental Antibody Transfer Following Maternal Immunization With a Pandemic 2009 Influenza A(H1N1) MF59-Adjuvanted Vaccine

(2010) GianVincenzo Zuccotti et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dynamin-like MxA GTPase: Structural Insights into Oligomerization and Implications for Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon β Promoter Stimulator 1

(2010) Atsushi Iwai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccination with whole inactivated virus vaccine affects the induction of heterosubtypic immunity against influenza virus A/H5N1 and immunodominance of virus-specific CD8+ T-cell responses in mice

(2010) R. Bodewes et al.   JOURNAL OF GENERAL VIROLOGY

Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

(2010) K. El Bakkouri et al.   JOURNAL OF IMMUNOLOGY

Influenza A Inhibits Th17-Mediated Host Defense against Bacterial Pneumonia in Mice

(2010) A. Kudva et al.   JOURNAL OF IMMUNOLOGY

The Role of Protein Kinase R in the Interferon Response

(2010) Agnieszka Pindel et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

New Insights into the Role of RNase L in Innate Immunity

(2010) Arindam Chakrabarti et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Evasion of natural killer cells by influenza virus

(2010) Hailong Guo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NKp46 O-Glycan Sequences That Are Involved in the Interaction with Hemagglutinin Type 1 of Influenza Virus

(2010) M. Mendelson et al.   JOURNAL OF VIROLOGY

A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo

(2010) G. M. Conenello et al.   JOURNAL OF VIROLOGY

Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin

(2010) H. Mao et al.   JOURNAL OF VIROLOGY

Recombinant Soluble, Multimeric HA and NA Exhibit Distinctive Types of Protection against Pandemic Swine-Origin 2009 A(H1N1) Influenza Virus Infection in Ferrets

(2010) B. J. Bosch et al.   JOURNAL OF VIROLOGY

The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon

(2010) K. M. Graef et al.   JOURNAL OF VIROLOGY

Serological surveys for 2009 pandemic influenza A H1N1

(2010) Carrie Reed et al.   LANCET

Memory CD4+ T cells induce innate responses independently of pathogen

(2010) Tara M Strutt et al.   NATURE MEDICINE

Influenza Immunization in Pregnancy — Antibody Responses in Mothers and Infants

(2010) Mark C. Steinhoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cross-reactive CD8+T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses

(2010) Stephanie Gras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes

(2010) T. T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasomes as mediators of immunity against influenza virus

(2010) Iris K. Pang et al.   TRENDS IN IMMUNOLOGY

Protection of pregnant mice, fetuses and neonates from lethality of H5N1 influenza viruses by maternal vaccination

(2010) Seon Do Hwang et al.   VACCINE

Differential effect of CD4+Foxp3+ T-regulatory cells on the B and T helper cell responses to influenza virus vaccination

(2010) Jacqueline Surls et al.   VACCINE

A new strategy of immune evasion by influenza A virus: Inhibition of monocyte differentiation into dendritic cells

(2010) Saikat Boliar et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Influenza A viruses: why focusing on M2e-based universal vaccines

(2010) Seyyed Mahmoud Ebrahimi et al.   VIRUS GENES

Targets for the Induction of Protective Immunity Against Influenza A Viruses

(2010) Rogier Bodewes et al.   Viruses-Basel

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Broadly Protective Monoclonal Antibodies against H3 Influenza Viruses following Sequential Immunization with Different Hemagglutinins

(2010) Taia T. Wang et al.   PLoS Pathogens

Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway

(2010) Zhenhong Guan et al.   Protein & Cell

Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells

(2009) Yongjin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Quick to remember, slow to forget: rapid recall responses of memory CD8+ T cells

(2009) Joanna R DiSpirito et al.   CELL RESEARCH

Heterogeneity and plasticity of T helper cells

(2009) Jinfang Zhu et al.   CELL RESEARCH

Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

(2009) Kanako Sugiyama et al.   EMBO JOURNAL

Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection

(2009) Jessica M. Moffat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

(2009) Michael Schotsaert et al.   Expert Review of Vaccines

Innate immune evasion strategies of influenza viruses

(2009) Benjamin G Hale et al.   Future Microbiology

Innate immune control and regulation of influenza virus infections

(2009) Jodi McGill et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pathogenesis of 1918 Pandemic and H5N1 Influenza Virus Infections in a Guinea Pig Model: Antiviral Potential of Exogenous Alpha Interferon To Reduce Virus Shedding

(2009) N. Van Hoeven et al.   JOURNAL OF VIROLOGY

Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis

(2009) H. Mao et al.   JOURNAL OF VIROLOGY

Yearly influenza vaccinations: a double-edged sword?

(2009) Rogier Bodewes et al.   LANCET INFECTIOUS DISEASES

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

(2009) Yusuke Nakanishi et al.   NATURE

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus

(2009) Kathy Hancock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses

(2009) Taeg S. Kim et al.   PLoS One

Vaccination against Human Influenza A/H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A/H5N1 Virus

(2009) Rogier Bodewes et al.   PLoS One

Dating the emergence of pandemic influenza viruses

(2009) Gavin J. D. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Infection of mice with a human influenza A/H3N2 virus induces protective immunity against lethal infection with influenza A/H5N1 virus

(2009) J.H.C.M. Kreijtz et al.   VACCINE

M2e-based universal influenza A vaccine

(2009) Walter Fiers et al.   VACCINE

The Role of Swine in the Generation of Novel Influenza Viruses

(2009) W. Ma et al.   Zoonoses and Public Health

The Role of Genomics in Tracking the Evolution of Influenza A Virus

(2009) Alice Carolyn McHardy et al.   PLoS Pathogens

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs

(2008) H. M. Kim et al.   JOURNAL OF VIROLOGY

Cross-Recognition of Avian H5N1 Influenza Virus by Human Cytotoxic T-Lymphocyte Populations Directed to Human Influenza A Virus

(2008) J. H. C. M. Kreijtz et al.   JOURNAL OF VIROLOGY

Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans

(2008) E. Assarsson et al.   JOURNAL OF VIROLOGY

Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China

(2008) Hua Wang et al.   LANCET

Human infection with highly pathogenic H5N1 influenza virus

(2008) Andrea Gambotto et al.   LANCET

Heterosubtypic immunity to influenza A virus: where do we stand?

(2008) Kristie M. Grebe et al.   MICROBES AND INFECTION

Division of labor between dendritic cell subsets of the lung

(2008) C H GeurtsvanKessel et al.   Mucosal Immunology

The contents of the syringe

(2008) Steven Salzberg   NATURE

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

(2008) Xiaocong Yu et al.   NATURE

The genomic and epidemiological dynamics of human influenza A virus

(2008) Andrew Rambaut et al.   NATURE

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Update on Avian Influenza A (H5N1) Virus Infection in Humans

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Structural basis for suppression of a host antiviral response by influenza A virus

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenicity of highly pathogenic avian influenza virus in mammals

(2008) Emmie de Wit et al.   VACCINE

Complement and natural antibody are required in the long-term memory response to influenza virus

(2008) Santiago Fernandez Gonzalez et al.   VACCINE

Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses

(2008) Colin A. Russell et al.   VACCINE

Characterizations of four monoclonal antibodies against M2 protein ectodomain of influenza A virus

(2008) Tong-Ming Fu et al.   VIROLOGY

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

(2008) Eva-K. Pauli et al.   PLoS Pathogens

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY