The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells

(2016) Md. Mostafizur Rahman et al.   CELLULAR SIGNALLING

Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling

(2016) Jung-Chien Cheng et al.   CELLULAR SIGNALLING

Cyclooxygenase 2: its regulation, role and impact in airway inflammation

(2016) N. N. Rumzhum et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin

(2015) Md. Mostafizur Rahman et al.   Scientific Reports

From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies

(2015) Maria Ciccone et al.   Frontiers in Oncology

Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells

(2014) E. Fuerst et al.   ALLERGY

Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A

(2014) Luke Hatchwell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation

(2014) Chih-Kai Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sphingosine 1-Phosphate Induces Neutrophil Chemoattractant IL-8: Repression by Steroids

(2014) Md. Mostafizur Rahman et al.   PLoS One

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

(2013) J. J. Oaks et al.   BLOOD

Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod)

(2013) Salma Buddaseth et al.   CANCER BIOLOGY & THERAPY

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

TLR2 ligand engagement upregulates airway smooth muscle TNFα-induced cytokine production

(2012) Melanie Manetsch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia

(2011) I. Cristobal et al.   HAEMATOLOGICA

Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: Mechanism of action and effect on cytokine secretion

(2010) John P. Moutzouris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

(2010) K. G. Roberts et al.   CANCER RESEARCH

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

Ceramide-dependent PP2A regulation of TNFα-induced IL-8 production in respiratory epithelial cells

(2009) Timothy T. Cornell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis

(2009) Javier Milara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Sphingosine-1-phosphate enhances IL-1β-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts

(2008) Takashi Ohama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Corticosteroids Reduce IL-6 in ASM Cells via Up-Regulation of MKP-1

(2008) Timo Quante et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL