标题
Molecular mechanisms regulating Proteinase‐Activated Receptors (PARs)
作者
关键词
-
出版物
FEBS Journal
Volume 288, Issue 8, Pages 2697-2726
出版商
Wiley
发表日期
2021-03-20
DOI
10.1111/febs.15829
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)
- (2020) Pierre E. Thibeault et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Novel Nonpeptidic PAR2 Ligands
- (2020) Ilona Klösel et al. ACS Medicinal Chemistry Letters
- Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
- (2020) Kuglae Kim et al. CELL
- The development of proteinase-activated receptor-2 modulators and the challenges involved
- (2020) Kathryn A. McIntosh et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling
- (2020) Naomi R. Latorraca et al. CELL
- Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time
- (2020) Anand Patwardhan et al. PHARMACOLOGICAL REVIEWS
- The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects
- (2020) Charlotte Avet et al. Communications Biology
- Molecular switches in GPCRs
- (2019) Slawomir Filipek CURRENT OPINION IN STRUCTURAL BIOLOGY
- Illuminating G-Protein-Coupling Selectivity of GPCRs
- (2019) Asuka Inoue et al. CELL
- High Affinity Fluorescent Probe for Proteinase-Activated Receptor 2 (PAR2)
- (2019) Jordan C. LeSarge et al. ACS Medicinal Chemistry Letters
- The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability
- (2019) Disha M. Gandhi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis
- (2019) Xiaojian Huang et al. Aging-US
- The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone
- (2019) Hidetsugu Asada et al. STRUCTURE
- Common activation mechanism of class A GPCRs
- (2019) Qingtong Zhou et al. eLife
- The Molecular Basis of G Protein–Coupled Receptor Activation
- (2018) William I. Weis et al. Annual Review of Biochemistry
- Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
- (2018) Andrija Sente et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury
- (2018) Karen De Ceunynck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
- (2018) Andrija Sente et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β
- (2017) Paul R. Lee et al. Journal of Neuroinflammation
- A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells
- (2017) Yuhong Jiang et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function
- (2017) Rithwik Ramachandran et al. MOLECULAR PHARMACOLOGY
- Selectivity determinants of GPCR–G-protein binding
- (2017) Tilman Flock et al. NATURE
- Structural insight into allosteric modulation of protease-activated receptor 2
- (2017) Robert K. Y. Cheng et al. NATURE
- Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
- (2017) Thomas J. Cahill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding
- (2017) Pancras C. Wong et al. Science Translational Medicine
- Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
- (2017) Satish Ranjan et al. Nature Communications
- PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation
- (2017) Simon J. Wilson et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease
- (2015) Paul A. Gurbel et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
- (2015) O. Aisiku et al. BLOOD
- The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathwaysin vitroandin vivo
- (2015) Scott Boitano et al. BRITISH JOURNAL OF PHARMACOLOGY
- Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor
- (2015) Haitao Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Potent Small Agonists of Protease Activated Receptor 2
- (2015) Mei-Kwan Yau et al. ACS Medicinal Chemistry Letters
- Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354
- (2014) Wandong Wen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity
- (2014) F. Stavenuiter et al. BLOOD
- Structure and putative signaling mechanism of Protease activated receptor 2 (PAR2) – A promising target for breast cancer
- (2014) Kavita Kumari Kakarala et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Biased Signaling of Protease-Activated Receptors
- (2014) Peishen Zhao et al. Frontiers in Endocrinology
- Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
- (2013) L. Burnier et al. BLOOD
- Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease
- (2013) M D Hollenberg et al. BRITISH JOURNAL OF PHARMACOLOGY
- Palmitoylation of Protease-activated Receptor-1 Regulates Adaptor Protein Complex-2 and -3 Interaction with Tyrosine-based Motifs and Endocytic Sorting
- (2013) Isabel Canto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)
- (2013) Koichiro Mihara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Noncanonical Matrix Metalloprotease-1-Protease-activated Receptor-1 Signaling Triggers Vascular Smooth Muscle Cell Dedifferentiation and Arterial Stenosis
- (2013) Karyn M. Austin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity
- (2013) Hyesook Yoon et al. JOURNAL OF NEUROCHEMISTRY
- Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
- (2013) Arun K. Shukla et al. NATURE
- Molecular signatures of G-protein-coupled receptors
- (2013) A. J. Venkatakrishnan et al. NATURE
- Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets
- (2013) Summer E. Young et al. PLoS One
- Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis
- (2013) Cong Lin et al. THORAX
- Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis
- (2012) E. S. Michael et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
- (2012) L. O. Mosnier et al. BLOOD
- Modulation of PAR1signalling by benzimidazole compounds
- (2012) S Asteriti et al. BRITISH JOURNAL OF PHARMACOLOGY
- Protease-activated receptor 1 (PAR1) coupling to Gq/11 but not to Gi/o or G12/13 is mediated by discrete amino acids within the receptor second intracellular loop
- (2012) Kelly L. McCoy et al. CELLULAR SIGNALLING
- Suppression of Arterial Thrombosis Without Affecting Hemostatic Parameters With a Cell-Penetrating PAR1 Pepducin
- (2012) Ping Zhang et al. CIRCULATION
- β-Adrenergic Receptor Stimulation Transactivates Protease-Activated Receptor 1 via Matrix Metalloproteinase 13 in Cardiac Cells
- (2012) Fabrice Jaffré et al. CIRCULATION
- Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies
- (2012) B. Trzaskowski et al. CURRENT MEDICINAL CHEMISTRY
- An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats
- (2012) Rink-Jan Lohman et al. FASEB JOURNAL
- Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development
- (2012) Katie O'Callaghan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the human κ-opioid receptor in complex with JDTic
- (2012) Huixian Wu et al. NATURE
- Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
- (2012) Aaron A. Thompson et al. NATURE
- Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
- (2012) Aashish Manglik et al. NATURE
- High-resolution crystal structure of human protease-activated receptor 1
- (2012) Cheng Zhang et al. NATURE
- Targeting proteinase-activated receptors: therapeutic potential and challenges
- (2012) Rithwik Ramachandran et al. NATURE REVIEWS DRUG DISCOVERY
- Proteinase-Activated Receptor-4 Plays a Major Role in the Recruitment of Neutrophils Induced by Trypsin or Carrageenan during Pleurisy in Mice
- (2012) L.F. Gomides et al. PHARMACOLOGY
- Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel
- (2012) Tongguang Wang et al. PLoS One
- Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor
- (2012) Chris Dockendorff et al. ACS Medicinal Chemistry Letters
- Targeting Protease-Activated Receptor-1 with Cell-Penetrating Pepducins in Lung Cancer
- (2011) Jaroslaw Cisowski et al. AMERICAN JOURNAL OF PATHOLOGY
- Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes
- (2011) T. Madhusudhan et al. BLOOD
- Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
- (2011) P. Sen et al. BLOOD
- Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)
- (2011) JY Suen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Structural insights into agonist-induced activation of G-protein-coupled receptors
- (2011) Xavier Deupi et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis
- (2011) Sarah L. Tressel et al. EMBO Molecular Medicine
- Adaptor Protein Complex-2 (AP-2) and Epsin-1 Mediate Protease-activated Receptor-1 Internalization via Phosphorylation- and Ubiquitination-dependent Sorting Signals
- (2011) Buxin Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Helix 8 Plays a Crucial Role in Bradykinin B2Receptor Trafficking and Signaling
- (2011) Jens Feierler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)
- (2011) Rithwik Ramachandran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Helix 8 of the M1 Muscarinic Acetylcholine Receptor: Scanning Mutagenesis Delineates a G Protein Recognition Site
- (2011) R. G. Kaye et al. MOLECULAR PHARMACOLOGY
- Structure, function and pathophysiology of protease activated receptors
- (2011) Mark N. Adams et al. PHARMACOLOGY & THERAPEUTICS
- The Role of Palmitoylation in Signalling, Cellular Trafficking and Plasma Membrane Localization of Protease-Activated Receptor-2
- (2011) Mark N. Adams et al. PLoS One
- Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins
- (2011) L. M. Sevigny et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through -arrestin and dishevelled-2 scaffolds
- (2011) U. J. K. Soh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process
- (2011) K. Kirchberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes
- (2010) Sang Eun Lee et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
- Signal transduction by protease-activated receptors
- (2010) Unice JK Soh et al. BRITISH JOURNAL OF PHARMACOLOGY
- Novel Agonists and Antagonists for Human Protease Activated Receptor 2
- (2010) Grant D. Barry et al. JOURNAL OF MEDICINAL CHEMISTRY
- Functional Selectivity and Biased Receptor Signaling
- (2010) T. Kenakin JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Teaching old receptors new tricks: biasing seven-transmembrane receptors
- (2010) Sudarshan Rajagopal et al. NATURE REVIEWS DRUG DISCOVERY
- Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
- (2010) T. Kenakin et al. PHARMACOLOGICAL REVIEWS
- Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
- (2010) B. Wu et al. SCIENCE
- Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling
- (2009) Fui Goon Goh et al. BRITISH JOURNAL OF PHARMACOLOGY
- Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responsesin vitroandin vivo
- (2009) T Kanke et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cathepsin G Recruits Osteoclast Precursors via Proteolytic Activation of Protease-Activated Receptor-1
- (2009) T. J. Wilson et al. CANCER RESEARCH
- Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis
- (2009) E. Yang et al. CANCER RESEARCH
- Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site
- (2009) Vishal Trivedi et al. CELL
- Discovery of Novel Protease Activated Receptors 1 Antagonists with Potent Antithrombotic Activity in Vivo
- (2009) Michel Perez et al. JOURNAL OF MEDICINAL CHEMISTRY
- Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor
- (2009) R. A. SCHUEPBACH et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Role of helix 8 in G protein-coupled receptors based on structure–function studies on the type 1 angiotensin receptor
- (2009) John Huynh et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The structure and function of G-protein-coupled receptors
- (2009) Daniel M. Rosenbaum et al. NATURE
- The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease
- (2009) Victor L. Serebruany et al. THROMBOSIS AND HAEMOSTASIS
- Protease-Activated Receptor 4 Uses Anionic Residues To Interact with α-Thrombin in the Absence or Presence of Protease-Activated Receptor 1†
- (2008) Marvin T. Nieman BIOCHEMISTRY
- Proteinases as hormones: targets and mechanisms for proteolytic signaling
- (2008) Kristina K. Hansen et al. BIOLOGICAL CHEMISTRY
- Kallikrein-related Peptidase 4 (KLK4) Initiates Intracellular Signaling via Protease-activated Receptors (PARs)
- (2008) Andrew J. Ramsay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Potent and Selective Small-Molecule PAR-2 Agonists
- (2008) Jimmi Gerner Seitzberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity
- (2008) Samuel Chackalamannil et al. JOURNAL OF MEDICINAL CHEMISTRY
- Derivatized 2-Furoyl-LIGRLO-amide, a Versatile and Selective Probe for Proteinase-Activated Receptor 2: Binding and Visualization
- (2008) M. D. Hollenberg et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists
- (2008) L. R. Gardell et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Thrombin Induces Fibroblast CCL2/JE Production and Release via Coupling of PAR1 to Gαq and Cooperation between ERK1/2 and Rho Kinase Signaling Pathways
- (2008) Xiaoling Deng et al. MOLECULAR BIOLOGY OF THE CELL
- Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer
- (2008) A. Agarwal et al. MOLECULAR CANCER THERAPEUTICS
- Crystal structure of opsin in its G-protein-interacting conformation
- (2008) Patrick Scheerer et al. NATURE
- Distinct conformational changes in -arrestin report biased agonism at seven-transmembrane receptors
- (2008) A. K. Shukla et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of a new peptide agonist of the protease-activated receptor-1
- (2007) Yingying Mao et al. BIOCHEMICAL PHARMACOLOGY
- Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives
- (2007) Hua-Sin Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more
- (2007) R Ramachandran et al. BRITISH JOURNAL OF PHARMACOLOGY
- Activation of Proteinase-Activated Receptor-2 by Human Kallikrein-Related Peptidases
- (2007) Kristina Stefansson et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
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