Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

iNKT Cells in Secondary Progressive Multiple Sclerosis Patients Display Pro-inflammatory Profiles

(2016) Sara De Biasi et al.   Frontiers in Immunology

Arachidonic acid induces brain endothelial cell apoptosis via p38-MAPK and intracellular calcium signaling

(2015) Justin Evans et al.   MICROVASCULAR RESEARCH

Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset

(2014) Dario Seppi et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebrospinal fluid detection of interleukin-1β in phase of remission predicts disease progression in multiple sclerosis

(2014) Silvia Rossi et al.   Journal of Neuroinflammation

Activation of TRPML1 Clears Intraneuronal A  in Preclinical Models of HIV Infection

(2014) M. Bae et al.   JOURNAL OF NEUROSCIENCE

In Vivo Detection of Diffuse Inflammation in Secondary Progressive Multiple Sclerosis Using PET Imaging and the Radioligand 11C-PK11195

(2014) E. Rissanen et al.   JOURNAL OF NUCLEAR MEDICINE

Functional role of protease activated receptors in vascular biology

(2014) Maria Adele Alberelli et al.   VASCULAR PHARMACOLOGY

Cortical thickness at the time of the initial attack in two patients with paediatric relapsing–remitting multiple sclerosis

(2013) Alberto Fernández-Jaén et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy

(2013) Joshua E. Burda et al.   GLIA

Brain atrophy and lesion load predict long term disability in multiple sclerosis

(2013) Veronica Popescu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

CCL5-glutamate interaction in central nervous system: Early and acute presynaptic defects in EAE mice

(2013) Silvia Di Prisco et al.   NEUROPHARMACOLOGY

Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression

(2013) Jeppe Romme Christensen et al.   PLoS One

Biomarker Report from the Phase II Lamotrigine Trial in Secondary Progressive MS – Neurofilament as a Surrogate of Disease Progression

(2013) Sharmilee Gnanapavan et al.   PLoS One

Grey matter damage in multiple sclerosis

(2013) Roel Klaver et al.   Prion

Cortical lesion load associates with progression of disability in multiple sclerosis

(2012) M. Calabrese et al.   BRAIN

Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity

(2012) Antoine G. Almonte et al.   JOURNAL OF NEUROCHEMISTRY

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Comparison of the effect of aspirin and amantadine for the treatment of fatigue in multiple sclerosis: a randomized, blinded, crossover study

(2012) Vahid Shaygannejad et al.   NEUROLOGICAL RESEARCH

Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

(2012) Tongguang Wang et al.   PLoS One

Interleukin-1β causes synaptic hyperexcitability in multiple sclerosis

(2011) Silvia Rossi et al.   ANNALS OF NEUROLOGY

Proteinase-activated receptor-1 mediates dorsal root ganglion neuronal degeneration in HIV/AIDS

(2011) Shaona Acharjee et al.   BRAIN

A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility

(2011) W S Bush et al.   GENES AND IMMUNITY

Intravenous Anakinra can Achieve Experimentally Effective Concentrations in the Central Nervous System within a Therapeutic Time Window: Results of a Dose-Ranging Study

(2010) James Galea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activated T-Cells Inhibit Neurogenesis by Releasing Granzyme B: Rescue by Kv1.3 Blockers

(2010) T. Wang et al.   JOURNAL OF NEUROSCIENCE

Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes

(2010) N. De Stefano et al.   NEUROLOGY

Ectopic T-Cell Specificity and Absence of Perforin and Granzyme B Alleviate Neural Damage in Oligodendrocyte Mutant Mice

(2009) Antje Kroner et al.   AMERICAN JOURNAL OF PATHOLOGY

A substantial number of Rasmussen syndrome patients have increased IgG, CD4+T cells, TNFα, and Granzyme B in CSF

(2009) Yukitoshi Takahashi et al.   EPILEPSIA

The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy

(2009) Irena Dujmovic et al.   JOURNAL OF NEUROIMMUNOLOGY

Relative Importance of Proteinase-Activated Receptor-1 Versus Matrix Metalloproteinases in Intracerebral Hemorrhage-Mediated Neurotoxicity in Mice

(2009) Mengzhou Xue et al.   STROKE