Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

Dimebon Reduces the Levels of Aggregated Amyloidogenic Protein Forms in Detergent-Insoluble Fractions In Vivo

(2012) A. A. Ustyugov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon

(2012) Thelma R. Cowley et al.   NEUROCHEMICAL RESEARCH

Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion

(2012) Werner J. Geldenhuys et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

(2012) R. Tesla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

(2012) H. De Jesus-Cortes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys

(2011) Scott J Webster et al.   BRITISH JOURNAL OF PHARMACOLOGY

Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease

(2011) Jun Wang et al.   Molecular Neurodegeneration

Dimebon Does Not Ameliorate Pathological Changes Caused by Expression of Truncated (1–120) Human Alpha-Synuclein in Dopaminergic Neurons of Transgenic Mice

(2011) Tatyana A. Shelkovnikova et al.   Neurodegenerative Diseases

Latrepirdine increases cerebral glucose utilization in aged mice as measured by [18F]-fluorodeoxyglucose positron emission tomography

(2011) M. Day et al.   NEUROSCIENCE

Dimebon Slows Progression of Proteinopathy in γ-Synuclein Transgenic Mice

(2011) Sergey O. Bachurin et al.   NEUROTOXICITY RESEARCH

A Randomized, Placebo-Controlled Trial of Latrepirdine in Huntington Disease

(2010) Karl Kieburtz   ARCHIVES OF NEUROLOGY

Discovery of a Proneurogenic, Neuroprotective Chemical

(2010) Andrew A. Pieper et al.   CELL

From Anti-allergic to Anti-Alzheimer ’ s: Molecular Pharmacology of Dimebon™

(2010) I. Okun et al.   Current Alzheimer Research

Functional Genomics of Brain Aging and Alzheimers Disease: Focus on Selective Neuronal Vulnerability

(2010) Xinkun Wang et al.   CURRENT GENOMICS

Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-D-aspartate Receptor Antagonism

(2010) M. Giorgetti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanism matters

(2010)   NATURE MEDICINE

Learning from failure

(2010)   NATURE REVIEWS DRUG DISCOVERY

Dimebon Inhibits Calcium-Induced Swelling of Rat Brain Mitochondria But Does Not Alter Calcium Retention or Cytochrome C Release

(2010) Kranthi Kumari Naga et al.   NEUROMOLECULAR MEDICINE

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

(2010) Julie Vignisse et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dimebolin is a 5-HT 6 antagonist with acute cognition enhancing activities

(2009) Hervé Schaffhauser et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles

(2009) Alexandre V. Ivachtchenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hindering of proteinopathy-induced neurodegeneration as a new mechanism of action for neuroprotectors and cognition enhancing compounds

(2009) S. O. Bachurin et al.   Doklady Biochemistry and Biophysics

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

(2009) Nora Göckler et al.   FEBS Journal

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models

(2009) Makiko Yamashita et al.   FEBS LETTERS

β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)

(2009) T. Herraiz et al.   FOOD AND CHEMICAL TOXICOLOGY

Aβ aggregation and possible implications in Alzheimer's disease pathogenesis

(2009) Prashant R. Bharadwaj et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synaptic Activity Reduces Intraneuronal A , Promotes APP Transport to Synapses, and Protects against A -Related Synaptic Alterations

(2009) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

(2009) John W Steele et al.   Molecular Neurodegeneration

APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk

(2009) Onofre Combarros et al.   NEUROBIOLOGY OF AGING

Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells

(2008) Yoo Jung Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dimebon in Alzheimer's disease: old drug for new indication

(2008) Alistair Burns et al.   LANCET

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Polyphenols as Potential Inhibitors of Amyloid Aggregation and Toxicity:Possible Significance to Alzheimers Disease

(2008) S. Bastianetto et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Evaluation of Dimebon in cellular model of Huntington's disease

(2008) Jun Wu et al.   Molecular Neurodegeneration

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON