Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

Beyond amyloid: a diverse portfolio of novel drug discovery programs for Alzheimer's disease and related dementias

(2012) Rachel F Lane et al.   Alzheimers Research & Therapy

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease

(2011) Jun Wang et al.   Molecular Neurodegeneration

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

A Randomized, Placebo-Controlled Trial of Latrepirdine in Huntington Disease

(2010) Karl Kieburtz   ARCHIVES OF NEUROLOGY

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Discovery of a Proneurogenic, Neuroprotective Chemical

(2010) Andrew A. Pieper et al.   CELL

Protein Secretion: Unconventional Exit by Exophagy

(2010) Hilde Abrahamsen et al.   CURRENT BIOLOGY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-D-aspartate Receptor Antagonism

(2010) M. Giorgetti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Dimebolin is a 5-HT 6 antagonist with acute cognition enhancing activities

(2009) Hervé Schaffhauser et al.   BIOCHEMICAL PHARMACOLOGY

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

(2009) Zhenyu Yue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

(2009) John W Steele et al.   Molecular Neurodegeneration

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Evaluation of Dimebon in cellular model of Huntington's disease

(2008) Jun Wu et al.   Molecular Neurodegeneration

Receptor-independent, vacuolar ATPase-mediated cellular uptake of histamine receptor-1 ligands: Possible origin of pharmacological distortions and side effects

(2008) G MORISSETTE et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY