PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway

Mechanisms that drive telomere maintenance and recombination in human cancers

(2020) Alexander P Sobinoff et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

ALT: A Multi-Faceted Phenomenon

(2020) Aurore Sommer et al.   Genes

Control of DNA Damage Bypass by Ubiquitylation of PCNA

(2020) Brittany M. Ripley et al.   Genes

Shelterin and the replisome: at the intersection of telomere repair and replication

(2020) Alessandro Cicconi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RAD54 promotes alternative lengthening of telomeres by mediating branch migration

(2020) Emily Mason‐Osann et al.   EMBO REPORTS

RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

(2020) Wei Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae

(2020) Matan Arbel et al.   mBio

G-quadruplex Stabilization Fuels the ALT Pathway in ALT-positive Osteosarcoma Cells

(2020) Roberta Amato et al.   Genes

The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks

(2020) Alberto Jiménez-Martín et al.   Science Advances

Human PCNA Structure, Function and Interactions

(2020) Amaia González-Magaña et al.   Biomolecules

Nuclear body phase separation drives telomere clustering in ALT cancer cells

(2020) Huaiying Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Telomere replication—When the going gets tough

(2020) Susanna Stroik et al.   DNA REPAIR

Break-induced replication promotes fragile telomere formation

(2020) Zhe Yang et al.   GENES & DEVELOPMENT

The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability

(2019) Nicole Bettin et al.   Cells

Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination

(2019) Tianpeng Zhang et al.   PLoS Genetics

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

(2019) Mathilde Gauchier et al.   Science Advances

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

(2019) Robert Lu et al.   Nature Communications

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

(2019) Bruno Silva et al.   Nature Communications

Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

(2019) Mi-Sun Kang et al.   Nature Communications

Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathways

(2019) Yuji Masuda et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway

(2019) Mafei Xu et al.   Science Advances

ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

(2019) Su Hyung Park et al.   Nature Communications

RPA and RAD51: fork reversal, fork protection, and genome stability

(2018) Kamakoti P. Bhat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

(2018) Juan J. Montero et al.   Nature Communications

SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

(2018) Min Li et al.   Nature Communications

RPA and RAD51: fork reversal, fork protection, and genome stability

(2018) Kamakoti P. Bhat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preserving replication fork integrity and competence via the homologous recombination pathway

(2018) Anissia Ait Saada et al.   DNA REPAIR

EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization

(2018) Peng A et al.   Epigenetics & Chromatin

Maneuvers on PCNA Rings during DNA Replication and Repair

(2018) Dea Slade   Genes

Werner Syndrome Protein and DNA Replication

(2018) Shibani Mukherjee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures

(2018) Danielle Dahan et al.   NUCLEIC ACIDS RESEARCH

SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines

(2018) Mohiuddin Mohiuddin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice

(2017) Ayako L. Mochizuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines

(2017) Xueyin Wang et al.   MOLECULAR CELL

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

(2017) Katherine N. Choe et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge

(2017) Alexander P. Sobinoff et al.   TRENDS IN GENETICS

Structural basis of human PCNA sliding on DNA

(2017) Matteo De March et al.   Nature Communications

Role of the Pif1-PCNA Complex in Pol δ-Dependent Strand Displacement DNA Synthesis and Break-Induced Replication

(2017) Olga Buzovetsky et al.   Cell Reports

Solving the Telomere Replication Problem

(2017) Laetitia Maestroni et al.   Genes

R.I.P. to the PIP: PCNA-binding motif no longer considered specific

(2016) Elizabeth M. Boehm et al.   BIOESSAYS

Review: The lord of the rings: Structure and mechanism of the sliding clamp loader

(2016) Brian A. Kelch   BIOPOLYMERS

Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin

(2016) Jigar N. Bandaria et al.   CELL

Life and cancer without telomerase: ALT and other strategies for making sure ends (don’t) meet

(2016) Manasi S. Apte et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

MCM: one ring to rule them all

(2016) Tom D Deegan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DNA damage tolerance by recombination: Molecular pathways and DNA structures

(2016) Dana Branzei et al.   DNA REPAIR

FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway

(2016) Heather Root et al.   HUMAN MOLECULAR GENETICS

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

(2016) Elizabeth M. Boehm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks

(2016) Florian Rohleder et al.   NUCLEIC ACIDS RESEARCH

The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis

(2016) Peter Burkovics et al.   NUCLEIC ACIDS RESEARCH

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMARCAL1 Resolves Replication Stress at ALT Telomeres

(2016) Kelli E. Cox et al.   Cell Reports

PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1

(2016) Catherine Johnson et al.   Cell Reports

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress

(2016) Néstor García-Rodríguez et al.   Frontiers in Genetics

Identification of chromatin marks at TERRA promoter and encoding region

(2015) Yutaka Negishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

(2015) Mahesh Ramamoorthy et al.   CANCER CELL

Evolutionary conservation of the CDK targets in eukaryotic DNA replication initiation

(2015) Philip Zegerman   CHROMOSOMA

Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication

(2015) Madhusoodanan Urulangodi et al.   GENES & DEVELOPMENT

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

(2015) Grzegorz Sarek et al.   MOLECULAR CELL

Elg1, a central player in genome stability

(2015) Inbal Gazy et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA

(2015) Michael Schertzer et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis

(2015) Janice Ortega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular genetics of the telomere biology disorders

(2015) Alison A. Bertuch   RNA Biology

Telomere functions grounding on TERRA firma

(2015) Claus M. Azzalin et al.   TRENDS IN CELL BIOLOGY

Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions

(2015) Bernadette Nera et al.   Nature Communications

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Pif1 Helicase, a Negative Regulator of Telomerase, Acts Preferentially at Long Telomeres

(2015) Jane A. Phillips et al.   PLoS Genetics

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

(2015) Roxana E Georgescu et al.   eLife

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres

(2014) Adélaïde Saint-Léger et al.   CELL CYCLE

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Rad54 Functions as a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D Loop Formation

(2014) William Douglass Wright et al.   MOLECULAR CELL

Prereplication-complex formation: a molecular double take?

(2014) Hasan Yardimci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination

(2014) Dimitri Conomos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork

(2014) Roxana E Georgescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis

(2014) Ornella Cazzalini et al.   NUCLEIC ACIDS RESEARCH

Sequential switching of binding partners on PCNA during in vitro Okazaki fragment maturation

(2014) Daniel Dovrat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Break-induced replication: functions and molecular mechanism

(2013) Anna Malkova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

(2013) Peter Burkovics et al.   EMBO JOURNAL

Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

(2013) M. Scheibe et al.   GENOME RESEARCH

Genomes and G-Quadruplexes: For Better or for Worse

(2013) Madalena Tarsounas et al.   JOURNAL OF MOLECULAR BIOLOGY

The Elg1 Replication Factor C-like Complex Functions in PCNA Unloading during DNA Replication

(2013) Takashi Kubota et al.   MOLECULAR CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells

(2013) Agathe Bacquin et al.   NUCLEIC ACIDS RESEARCH

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes

(2013) Michael Lee et al.   NUCLEIC ACIDS RESEARCH

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression

(2012) M. Takawa et al.   CANCER RESEARCH

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells

(2012) Dimitri Conomos et al.   JOURNAL OF CELL BIOLOGY

Role of SUMO modification of human PCNA at stalled replication fork

(2012) Himabindu Gali et al.   NUCLEIC ACIDS RESEARCH

A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA

(2012) Joanne L. Parker et al.   NUCLEIC ACIDS RESEARCH

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

(2011) George-Lucian Moldovan et al.   MOLECULAR CELL

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

(2011) Noam Diamant et al.   NUCLEIC ACIDS RESEARCH

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

The Fanconi anemia pathway and DNA interstrand cross-link repair

(2011) Xiaoyu Su et al.   Protein & Cell

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

Break-induced replication: What is it and what is it for?

(2010) Bertrand Llorente et al.   CELL CYCLE

Mi-2/NuRD complex making inroads into DNA-damage response pathway

(2010) Da-Qiang Li et al.   CELL CYCLE

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

Revelation of p53-independent Function of MTA1 in DNA Damage Response via Modulation of the p21WAF1-Proliferating Cell Nuclear Antigen Pathway

(2010) Da-Qiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

Determination of enriched histone modifications in non-genic portions of the human genome

(2009) Jeffrey A Rosenfeld et al.   BMC GENOMICS

Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins

(2009) Wei-Qin Jiang et al.   JOURNAL OF CELL BIOLOGY

Identification of a novel, widespread, and functionally important PCNA-binding motif

(2009) Karin M. Gilljam et al.   JOURNAL OF CELL BIOLOGY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline

(2009) Aaron Mendez-Bermudez et al.   NUCLEIC ACIDS RESEARCH

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

Chromatin regulation and non-coding RNAs at mammalian telomeres

(2009) Stefan Schoeftner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SUMO Modification Regulates BLM and RAD51 Interaction at Damaged Replication Forks

(2009) Karen J. Ouyang et al.   PLOS BIOLOGY

SUMO modification of PCNA is controlled by DNA

(2008) Joanne L Parker et al.   EMBO JOURNAL

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells

(2008) A. Nabetani et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMOylation regulates Rad18-mediated template switch

(2008) Dana Branzei et al.   NATURE

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase  

(2008) N. Selak et al.   NUCLEIC ACIDS RESEARCH

Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

(2008) A. Niimi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA