Prereplication-complex formation: a molecular double take?

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker

(2013) Ernesto Arias-Palomo et al.   CELL

MCM Loading—An Open-and-Shut Case?

(2013) Rachel Y. Samson et al.   MOLECULAR CELL

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

(2013) Alejandra Fernández-Cid et al.   MOLECULAR CELL

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization

(2013) C. Evrin et al.   NUCLEIC ACIDS RESEARCH

DNA Replication Origins

(2013) A. C. Leonard et al.   Cold Spring Harbor Perspectives in Biology

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

(2013) Franziska Bleichert et al.   eLife

Clamp loader ATPases and the evolution of DNA replication machinery

(2012) Brian A Kelch et al.   BMC BIOLOGY

Activation of the replicative DNA helicase: breaking up is hard to do

(2012) Dominik Boos et al.   CURRENT OPINION IN CELL BIOLOGY

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

(2012) Artem Y. Lyubimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc6-Induced Conformational Changes in ORC Bound to Origin DNA Revealed by Cryo-Electron Microscopy

(2012) Jingchuan Sun et al.   STRUCTURE

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells 

(2011) Jingjing Zhang et al.   CELL CYCLE

Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases

(2011) Thomas J Takara et al.   EMBO JOURNAL

CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6

(2011) S. Chen et al.   GENES & DEVELOPMENT

MCM2-7 Form Double Hexamers at Licensed Origins inXenopusEgg Extract

(2011) Agnieszka Gambus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB

(2011) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved nucleosome positioning defines replication origins

(2010) M. L. Eaton et al.   GENES & DEVELOPMENT

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Synergy and Molecular Crosstalk between Bacterial Helicase Loaders and Replication Initiators

(2008) Melissa L. Mott et al.   CELL

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL