RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations

(2020) A. Takedachi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HumCFS: a database of fragile sites in human chromosomes

(2019) Rajesh Kumar et al.   BMC GENOMICS

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation

(2018) Bennie Lemmens et al.   MOLECULAR CELL

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing

(2018) Robert Hänsel-Hertsch et al.   Nature Protocols

Replication stress induces accumulation of FANCD2 at central region of large fragile genes

(2018) Yusuke Okamoto et al.   NUCLEIC ACIDS RESEARCH

Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers

(2018) Vladimir A Kuznetsov et al.   NUCLEIC ACIDS RESEARCH

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism

(2018) Özgün Özer et al.   Oncotarget

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

(2018) Morgane Macheret et al.   NATURE

Folate deficiency drives mitotic missegregation of the human FRAXA locus

(2018) Victoria A. Bjerregaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork

(2017) Shankar Parajuli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability

(2017) Peter C. Stirling et al.   JOURNAL OF MOLECULAR BIOLOGY

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

(2017) Ying Wai Chan et al.   NATURE CELL BIOLOGY

Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

(2017) Amanda C. Hall et al.   Nucleus

Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

(2017) Amanda C. Hall et al.   Nucleus

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

FANCD2 Facilitates Replication through Common Fragile Sites

(2016) Advaitha Madireddy et al.   MOLECULAR CELL

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

(2015) Rune Troelsgaard Pedersen et al.   JOURNAL OF CELL BIOLOGY

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

The core spliceosome as target and effector of non-canonical ATM signalling

(2015) Maria Tresini et al.   NATURE

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

(2015) Christian F. Nielsen et al.   Nature Communications

The origins and processing of ultra fine anaphase DNA bridges

(2014) Ying Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

(2014) Stephan Hamperl et al.   DNA REPAIR

Large transcription units unify copy number variants and common fragile sites arising under replication stress

(2014) Thomas E. Wilson et al.   GENOME RESEARCH

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region

(2014) Erick W. Loomis et al.   PLoS Genetics

Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita

(2013) Bari J. Ballew et al.   HUMAN GENETICS

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal–Hreidarsson syndrome

(2013) Zhong Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres

(2013) Jamie S.J. Wilson et al.   Cell Reports

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

(2013) Bari J. Ballew et al.   PLoS Genetics

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

(2012) Arkarachai Fungtammasan et al.   GENOME RESEARCH

Genome-wide association study of glioma and meta-analysis

(2012) Preetha Rajaraman et al.   HUMAN GENETICS

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

(2012) O. Yuce et al.   MOLECULAR AND CELLULAR BIOLOGY

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis

(2012) Xiaoli Wu et al.   TRANSGENIC RESEARCH

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

Cancer susceptibility variants and the risk of adult glioma in a US case–control study

(2011) Kathleen M. Egan et al.   JOURNAL OF NEURO-ONCOLOGY

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

(2011) K. N. Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 Genes Involved in the Double-Strand Break Repair Pathway Predict Glioblastoma Survival

(2010) Yanhong Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites

(2009) Allison A Burrow et al.   BMC GENOMICS

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

(2009) Olivier Sordet et al.   EMBO REPORTS

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility

(2009) Margaret Wrensch et al.   NATURE GENETICS

Genome-wide association study identifies five susceptibility loci for glioma

(2009) Sanjay Shete et al.   NATURE GENETICS

A role for monoubiquitinated FANCD2 at telomeres in ALT cells

(2009) Qiang Fan et al.   NUCLEIC ACIDS RESEARCH

Measurement of replication structures at the nanometer scale using super-resolution light microscopy

(2009) D. Baddeley et al.   NUCLEIC ACIDS RESEARCH

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE