标题
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
作者
关键词
-
出版物
CELL
Volume 184, Issue 9, Pages 2332-2347.e16
出版商
Elsevier BV
发表日期
2021-03-18
DOI
10.1016/j.cell.2021.03.028
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
- (2021) Tyler N. Starr et al. SCIENCE
- Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies
- (2021) Allison J. Greaney et al. Cell Host & Microbe
- Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
- (2021) Dami A. Collier et al. NATURE
- Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
- (2021) Kevin R. McCarthy et al. SCIENCE
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- A Novel Coronavirus from Patients with Pneumonia in China, 2019
- (2020) Na Zhu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses
- (2020) Michael Letko et al. Nature Microbiology
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
- (2020) Markus Hoffmann et al. MOLECULAR CELL
- Human neutralizing antibodies elicited by SARS-CoV-2 infection
- (2020) Bin Ju et al. NATURE
- Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
- (2020) Dora Pinto et al. NATURE
- A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
- (2020) Yan Wu et al. SCIENCE
- Site-specific glycan analysis of the SARS-CoV-2 spike
- (2020) Yasunori Watanabe et al. SCIENCE
- Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
- (2020) Katharine H. D. Crawford et al. Viruses-Basel
- A human monoclonal antibody blocking SARS-CoV-2 infection
- (2020) Chunyan Wang et al. Nature Communications
- Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
- (2020) Xiuyuan Ou et al. Nature Communications
- Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
- (2020) Tyler N. Starr et al. CELL
- The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity
- (2020) Qianqian Li et al. CELL
- Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
- (2020) Christopher O. Barnes et al. CELL
- Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
- (2020) Bette Korber et al. CELL
- Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
- (2020) Jiandong Huo et al. Cell Host & Microbe
- Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2
- (2020) James Brett Case et al. Cell Host & Microbe
- Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
- (2020) Markus Hoffmann et al. NATURE
- Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
- (2020) Noe B. Mercado et al. NATURE
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
- (2020) Kizzmekia S. Corbett et al. NATURE
- Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
- (2020) Lihong Liu et al. NATURE
- Potently neutralizing and protective human antibodies against SARS-CoV-2
- (2020) Seth J. Zost et al. NATURE
- Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
- (2020) Matthew McCallum et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects
- (2020) Antoni G. Wrobel et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
- (2020) Kizzmekia S. Corbett et al. NEW ENGLAND JOURNAL OF MEDICINE
- A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
- (2020) Xiangyang Chi et al. SCIENCE
- Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
- (2020) Alina Baum et al. SCIENCE
- Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
- (2020) Thomas F. Rogers et al. SCIENCE
- Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
- (2020) Ching-Lin Hsieh et al. SCIENCE
- Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
- (2020) Johanna Hansen et al. SCIENCE
- Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
- (2020) Philip J. M. Brouwer et al. SCIENCE
- Broad neutralization of SARS-related viruses by human monoclonal antibodies
- (2020) Anna Z. Wec et al. SCIENCE
- An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
- (2020) Jesse H. Erasmus et al. Science Translational Medicine
- SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
- (2020) Thomas Mandel Clausen et al. CELL
- Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
- (2020) Leonid Yurkovetskiy et al. CELL
- A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2
- (2020) Ahmed O. Hassan et al. CELL
- Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology
- (2020) Luca Piccoli et al. CELL
- Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection
- (2020) Stylianos Bournazos et al. NATURE
- Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine
- (2020) Cheryl Keech et al. NEW ENGLAND JOURNAL OF MEDICINE
- REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
- (2020) Alina Baum et al. SCIENCE
- Neuropilin-1 is a host factor for SARS-CoV-2 infection
- (2020) James L. Daly et al. SCIENCE
- Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
- (2020) Ludovico Cantuti-Castelvetri et al. SCIENCE
- Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
- (2020) M. Alejandra Tortorici et al. SCIENCE
- A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
- (2020) Xuping Xie et al. Nature Communications
- Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
- (2020) Antoni G. Wrobel et al. Nature Communications
- Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer
- (2020) Victoria A. Avanzato et al. CELL
- Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition
- (2020) Allison J. Greaney et al. Cell Host & Microbe
- Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo
- (2020) Alexandra Schäfer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
- (2020) Ali Punjani et al. NATURE METHODS
- Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host
- (2020) Bina Choi et al. NEW ENGLAND JOURNAL OF MEDICINE
- STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
- (2020) Robbert Boudewijns et al. Nature Communications
- SignalP 5.0 improves signal peptide predictions using deep neural networks
- (2019) José Juan Almagro Armenteros et al. NATURE BIOTECHNOLOGY
- Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion
- (2019) Alexandra C. Walls et al. CELL
- Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
- (2019) Haixia Zhou et al. Nature Communications
- Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD
- (2019) Nianshuang Wang et al. Cell Reports
- Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
- (2019) Dorothee Liebschner et al. Acta Crystallographica Section D-Structural Biology
- Real-time cryo-electron microscopy data preprocessing with Warp
- (2019) Dimitry Tegunov et al. NATURE METHODS
- Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape
- (2018) Lingshu Wang et al. JOURNAL OF VIROLOGY
- ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
- (2018) Tristan Ian Croll Acta Crystallographica Section D-Structural Biology
- Automatically Fixing Errors in Glycoprotein Structures with Rosetta
- (2018) Brandon Frenz et al. STRUCTURE
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis
- (2018) Jasenko Zivanov et al. IUCrJ
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection
- (2017) Lan Jiaming et al. VACCINE
- A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein
- (2017) Yingzhu Chen et al. Emerging Microbes & Infections
- Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta
- (2016) Ray Yu-Ruei Wang et al. eLife
- Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement
- (2015) Frank DiMaio et al. NATURE METHODS
- EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
- (2015) Benjamin A Barad et al. NATURE METHODS
- Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody
- (2015) Xiaoli Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prevention of overfitting in cryo-EM structure determination
- (2012) Sjors H W Scheres et al. NATURE METHODS
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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