miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors

Genetic and Non-Genetic Mechanisms of Resistance to BCR Signaling Inhibitors in B Cell Malignancies

(2020) Laura Ondrisova et al.   Frontiers in Oncology

BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo

(2019) Cédric Schleiss et al.   Scientific Reports

ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model

(2019) Chi-Ling Chiang et al.   BLOOD

B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

(2018) Wei Luo et al.   IMMUNITY

Rituximab primarily targets an intra-clonal BCR signaling proficient CLL subpopulation characterized by high CD20 levels

(2018) Gabriela Pavlasova et al.   LEUKEMIA

miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels

(2018) Katerina Musilova et al.   BLOOD

MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells

(2018) Katerina Cerna et al.   LEUKEMIA

miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis

(2018) Cuijuan Shi et al.   Cell Death & Disease

p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1

(2018) Katerina Cerna et al.   Oncotarget

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

(2017) Cody Paiva et al.   HAEMATOLOGICA

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood

(2017) T M Herndon et al.   LEUKEMIA

Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition

(2017) E Slinger et al.   LEUKEMIA

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy

(2017) Dan A. Landau et al.   Nature Communications

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

(2017) Cody Paiva et al.   HAEMATOLOGICA

The regulation of tumor-suppressive microRNA, miR-126, in chronic lymphocytic leukemia

(2017) Daphne Guinn et al.   Cancer Medicine

Chronic lymphocytic leukaemia

(2017) Thomas J. Kipps et al.   Nature Reviews Disease Primers

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL

(2016) Annalisa D’Avola et al.   BLOOD

Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis

(2016) G. Pavlasova et al.   BLOOD

The role of miR-29 family members in malignant hematopoiesis

(2014) Sona Kollinerova et al.   BIOMEDICAL PAPERS-OLOMOUC

MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

(2014) B. Cui et al.   BLOOD

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

(2014) M. Mraz et al.   BLOOD

Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation

(2014) F Palacios et al.   LEUKEMIA

miR-155 expression is associated with chemoimmunotherapy outcome and is modulated by Bruton’s tyrosine kinase inhibition with Ibrutinib

(2014) D Guinn et al.   LEUKEMIA

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

(2014) K Musilova et al.   LEUKEMIA

TRAF2 regulates the cytoplasmic/nuclear distribution of TRAF4 and its biological function in breast cancer cells

(2013) Xiaoli Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

(2013) M. F. Pascutti et al.   BLOOD

Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia

(2013) Matthew J. Ahearne et al.   BRITISH JOURNAL OF HAEMATOLOGY

TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer

(2013) W. Li et al.   CANCER RESEARCH

Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia

(2013) Jana Kminkova et al.   CARCINOGENESIS

The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis

(2013) Jorge Henao-Mejia et al.   IMMUNITY

MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

(2013) Marek Mraz et al.   LEUKEMIA & LYMPHOMA

TRAF4 Is a Novel Phosphoinositide-Binding Protein Modulating Tight Junctions and Favoring Cell Migration

(2013) Adrien Rousseau et al.   PLOS BIOLOGY

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

(2012) M. Mraz et al.   BLOOD

The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state

(2012) E. Tili et al.   BLOOD

Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

(2012) Xinwei Zhang et al.   CANCER CELL

The hunting of targets: challenge in miRNA research

(2012) F Akbari Moqadam et al.   LEUKEMIA

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

MicroRNA profiles of t(14;18)-negative follicular lymphoma support a late germinal center B-cell phenotype

(2011) E. Leich et al.   BLOOD

A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

(2011) D. Bagnara et al.   BLOOD

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

(2011) S. E. M. Herman et al.   BLOOD

Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease

(2011) Robert C. Rickert et al.   IMMUNOLOGICAL REVIEWS

Molecular Mechanisms of TNFR-associated Factor 6 (TRAF6) Utilization by the Oncogenic Viral Mimic of CD40, Latent Membrane Protein 1 (LMP1)

(2011) Kelly M. Arcipowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The functional in vitro response to CD40 ligation reflects a different clinical outcome in patients with chronic lymphocytic leukemia

(2011) C Scielzo et al.   LEUKEMIA

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(2011) Carlo Calissano et al.   MOLECULAR MEDICINE

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma

(2010) J.-J. Zhao et al.   BLOOD

microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival

(2010) S. Rossi et al.   BLOOD

Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro

(2010) Panayiotis Panayiotidis et al.   BRITISH JOURNAL OF HAEMATOLOGY

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

Target mRNA abundance dilutes microRNA and siRNA activity

(2010) Aaron Arvey et al.   Molecular Systems Biology

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

MicroRNA isolation and stability in stored RNA samples

(2009) M. Mraz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification

(2009) B. Stamatopoulos et al.   BLOOD

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities

(2009) M Mraz et al.   LEUKEMIA

MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes

(2009) Marek Mraz et al.   LEUKEMIA & LYMPHOMA

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia

(2008) Shanique Palmer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage

(2008) Sergei B. Koralov et al.   CELL

Roles of TRAF molecules in B lymphocyte function

(2008) Ping Xie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

(2008) Yair Dorsett et al.   IMMUNITY

Tumor Necrosis Factor Receptor-Associated Factor 4 Is a Dynamic Tight Junction-Related Shuttle Protein Involved in Epithelium Homeostasis

(2008) Valérie Kédinger et al.   PLoS One