Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation

CK2 kinase activity but not its binding to CK2 promoter regions is implicated in the regulation of CK2α and CK2β gene expressions

(2013) Sarah Lupp et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

How the microenvironment wires the natural history of chronic lymphocytic leukemia

(2013) Federico Caligaris-Cappio et al.   SEMINARS IN CANCER BIOLOGY

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma

(2012) L. Xie et al.   BLOOD

Trastuzumab-Resistant Cells Rely on a HER2-PI3K-FoxO-Survivin Axis and Are Sensitive to PI3K Inhibitors

(2012) A. Chakrabarty et al.   CANCER RESEARCH

Emerging Roles of MicroRNA-22 in Human Disease and Normal Physiology

(2012) J. Xiong   CURRENT MOLECULAR MEDICINE

Calpain 2 Regulates Akt-FoxO-p27Kip1Protein Signaling Pathway in Mammary Carcinoma

(2012) Wai-chi Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment

(2012) P Moreno et al.   LEUKEMIA

Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia

(2012) Zhi-Jian Zou et al.   LEUKEMIA & LYMPHOMA

OCT4 Positively Regulates Survivin Expression to Promote Cancer Cell Proliferation and Leads to Poor Prognosis in Esophageal Squamous Cell Carcinoma

(2012) Chunguang Li et al.   PLoS One

Cell-Penetrating TAT-FOXO3 Fusion Proteins Induce Apoptotic Cell Death in Leukemic Cells

(2011) M. Essafi et al.   MOLECULAR CANCER THERAPEUTICS

Unknown

(2011) Carlo Calissano et al.   MOLECULAR MEDICINE

Regulation of survivin by PI3K/Akt/p70S6K1 pathway

(2010) Peng Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia

(2010) L. R. Martins et al.   BLOOD

Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

(2010) M. Shehata et al.   BLOOD

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease

(2010) F. Palacios et al.   BLOOD

MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27

(2010) M. Frenquelli et al.   BLOOD

Phosphatidylinositol 3-kinase-  inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

(2010) S. E. M. Herman et al.   BLOOD

miR-22 Forms a Regulatory Loop in PTEN/AKT Pathway and Modulates Signaling Kinetics

(2010) Nadav Bar et al.   PLoS One

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

miR-22 functions as a micro-oncogene in transformed human bronchial epithelial cells induced by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide

(2010) Linhua Liu et al.   TOXICOLOGY IN VITRO

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3

(2009) S. Fukuda et al.   BLOOD

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

(2009) J. A. Burger et al.   BLOOD

CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival

(2009) A. Zucchetto et al.   CANCER RESEARCH

Chronic lymphocytic leukaemia

(2008) G Dighiero et al.   LANCET

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD